Table of Content

Open Access Review

The Role of Genetic Counseling in Gynecological Oncology

Ciro Comparetto, Florence Dupré, Franco Borruto
Received: July 15, 2019; Published: December 12, 2019; doi:10.21926/obm.genet.1904101

Abstract: Background: Clinical or medical genetics deals with the study and diagnosis of genetic diseases. It is oriented to the formulation of the clinical diagnosis of genetic diseases and genetic counseling, in order to evaluate the possible reproductive risk for the patient and his family. The geneticist [...]

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Open Access Original Research

Women’s Perceptions of the Embodied Experience of Osteoporosis across the Lifecourse

Alyson Holland, Amanda Lorbergs
Received: October 29, 2019; Published: December 12, 2019; doi:10.21926/obm.geriatr.1904093

Abstract: Beliefs about the daily experience of a disease are used to identify risk and motivate participation in prevention. For osteoporosis, a disease that is affected by health behaviours throughout the lifecourse, individual perceptions of the disease can affect health decisions and future disease preval [...]

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Open Access Original Research

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

Renate Verkaik, Iris van der Heide, Eugenie van Eerden, Peter Spreeuwenberg, Erik Scherder, Anneke L. Francke
Received: April 02, 2019; Published: December 11, 2019; doi:10.21926/obm.geriatr.1904092

Abstract: Background: Studies of the effectiveness of psychosocial interventions indicate that sensory stimulation is a promising approach to reduce psychological and behavioural disturbances in people with dementia. A relatively new approach is enriched multi-sensory stimulation. Enriched multi-sensory stimu [...]

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Open Access Original Research

Exploring Quality of Sleep, Perceived Stress and Resilience in Cancer Survivorship: A Feasibility Study of Mindfulness in Motion

Maryanna D. Klatt, Emaline Wise, Olivia Gabram, Megan Huber, Lai Wei, Mira Katz
Received: April 02, 2019; Published: December 11, 2019; doi:10.21926/obm.neurobiol.1904047

Abstract: (1) Background: The global principles of Mindfulness-Based Stress Reduction (MBSR) have led to the creation of Mindfulness-Based Interventions (MBIs), which are interventions that retrain the mind to modify its usual stress response to increase coping and resilience. Mindfulness in Motion (MIM) is a [...]

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Open Access Review

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Horst J. Koch
Received: August 06, 2019; Published: December 04, 2019; doi:10.21926/obm.geriatr.1904091

Abstract: The prevalence of Late-life Depression (LLD) is estimated between 10 and 15 % and therefore LLD is a considerable world-wide problem. The psychopathology is not substantially different from that of depressive episodes in young adults, but somatic complaints in combination of end-of-life perspective [...]

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Open Access Review

The Association between Bone Turnover Markers and Fracture in People with Diabetes: A Systematic Review and Meta-Analysis

Katrine Hygum, Jakob Starup-Linde, Torben Harsløf, Bente Langdahl
Received: August 29, 2019; Published: December 04, 2019; doi:10.21926/obm.geriatr.1904090

Abstract: Background: The increased fracture risk in persons with diabetes is underestimated by conventional fracture predictors. The aims of this study were to conduct a systematic review and a meta-analysis to compare the levels of bone turnover markers (BTM) in persons with diabetes with and without fractu [...]

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Open Access Hypothesis

Combination of the Hansemann-Boveri, Warburg, and Knudson Theories of Cancer, Based on Failure of Missegregation Damage Mitigation

Kjeld C. Engvild
Received: July 17, 2019; Published: December 3, 2019; doi:10.21926/obm.genet.1904100

Abstract: The Hansemann-Boveri aneuploidy theory, the Warburg aerobic glycolysis theory, and the Knudson two-hit mutation theory can be seen as different aspects of a theory where the very common chromosome missegregation damage is mitigated by several quite different mechanisms. Cancer only occurs when all o [...]

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Open Access Review

Therapeutic Apheresis in Prevention and Treatment of Antibody-Mediated Rejection of Renal Allografts

Maurizio Salvadori, Aris Tsalouchos
Received: October 13, 2019; Published: December 02, 2019; doi:10.21926/obm.transplant.1904093

Abstract: Antibody-mediated rejection represents a significant barrier to favourable long-term outcomes after kidney transplantation and is the most common cause of allograft failure. Therapeutic apheresis techniques associated with other treatments, such as immunosuppressive drugs, are commonly used in the p [...]

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Open Access Original Research

Automated Movement Feedback for Recovering Independence in the Sit-to-Stand Movement in an Older Population: A Pilot Randomised Controlled Trial of a Novel System

Siu Fai Ho, Avril Thomson, Tricia Moylan, Julie McGuckin, Andrew Kerr
Received: September 23, 2019; Published: December 02, 2019; doi:10.21926/obm.geriatr.1904089

Abstract: Background The sit-to-stand (StS) movement is a frequently performed task critical to independent living that is both difficult to perform and associated with falls in older populations. Consequently, the recovery of this movement through supervised practice is a priority during the rehabilitation [...]

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Open Access Review

Alzheimer’s Disease: Is a Dysfunctional Mevalonate Biosynthetic Pathway the Master-Inducer of Deleterious Changes in Cell Physiology?

Arnold De Loof, Liliane Schoofs
Received: October 03, 2019; Published: November 29, 2019; doi:10.21926/obm.neurobiol.1904046

Abstract: The awareness is growing that the proteins amyloid-beta (Aβ) and tau are rather a result of Alzheimer’s disease (AD) than its cause. Similarly, doubt reigns about the degree of causality of high plasma cholesterol/lipids (the fat connection) and of prenylation. An important conceptual addition to [...]

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