Konstantinos Manganas, Sophia Delicou, Aikaterini Xydaki, Zoi Pallantza
Received: May 19, 2019; Published: September 17, 2019; doi:10.21926/obm.genet.1903095

Abstract: Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt hemoglobin synthesis. Thalassemia intermediate is referred to a group of disorders with a less severe form of the disease when compared with thalassemia major. We present the case of a 60 year old w [...]

Laura Suarez, Reem M.A. Shafi, Maria I. Lapid
Received: May 14, 2019; Published: September 16, 2019; doi:10.21926/obm.geriatr.1903074

Abstract: Purpose of Review: Dementia is a progressive and debilitating condition that affects millions of patients in the United States with an enormous impact on healthcare costs, caregivers, and society. Patients with dementia often experience dementia-related neuropsychiatric disturbances, commonly known [...]

Joseph S. D'Arrigo
Received: August 22, 2019; Published: September 16, 2019; doi:10.21926/obm.neurobiol.1903040

Abstract: Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

Johanne Traeger-Synodinos, François Rousseau
Received: September 6, 2019; Published: September 11, 2019; doi:10.21926/obm.genet.1903094

Abstract: We present here the content and articles of this special issue on genetic screening, putting them in perspective with the field and between themselves.

Siavash Jafari, Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, Ashkan Nasr
Received: August 11, 2019; Published: September 09, 2019; doi:10.21926/obm.neurobiol.1903039

Abstract: Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

Randolph James, Amy Lawson Moore, Dick M Carpenter II, Terissa Michele Miller, Christina Ledbetter
Received: April 29, 2019; Published: September 06, 2019; doi:10.21926/obm.icm.1903054

Abstract: (1) Background: The current study examined a multifaceted anti-neuroinflammatory intervention that included physical exercise, mental exercise, grain-free/sugar-free diet, anti-inflammatory nutritional supplements, sleep optimization, and stress management within the context of a functional medicine [...]

Damien Bouvier, Yves Giguère
Received: July 1, 2019; Published: September 6, 2019; doi:10.21926/obm.genet.1903093

Abstract: Newborn screening (NBS) for inborn errors of metabolism (IEM) was introduced more than 50 years ago with the testing of phenylketonuria (PKU) using blood spots deposited on a filter paper after heel prick. NBS aims to identify early after birth inherited disorders for which clinical management and p [...]

Caymen M. Novak, Eric N. Horst, Shreya Raghavan, Geeta Mehta
Received: June 17, 2019; Published: September 6, 2019; doi:10.21926/obm.genet.1903092

Abstract: Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, metastasis, and has [...]

Anita Modi, Sherif Beniameen Mossad
Received: July 07, 2019; Published: September 06, 2019; doi:10.21926/obm.transplant.1903085

Abstract: Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of m [...]

Ugo Chiocchini, Giovanni Savarese
Received: May 14, 2019; Published: September 05, 2019; doi:10.21926/jept.1903003

Abstract: Background. The Regione Lazio - Direzione Regionale dello Sviluppo Economico e delle Attività Produttive (RL – DRSEAP), carrying out its public functions to govern the use of mineral resources including thermal water, planned the exploitation of the Viterbo hydrothermal system on the basis of a conc [...]