Table of Content

Open Access Communication

Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models

Kwang Poo Chang, Dennis K. P. Ng, Chia-Kwung Fan, Ramesh B. Batchu, Bala K. Kolli
Received: December 29, 2020; Published: February 24, 2020; doi:10.21926/obm.genet.2001103

Abstract: The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic [...]

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Open Access Editorial

Another Productive Year

Joep Geraedts
Received: January 14, 2020; Published: January 14, 2020; doi:10.21926/obm.genet.2001102

Abstract: At the beginning of a new year it is always good to look both backwards and forwards and to highlight a few items that are relevant with respect to the long-term development of our journal. As everybody knows, the principle of open access publishing is that the authors pay fees (the article‐processi [...]

26 233

Open Access Review

The Role of Genetic Counseling in Gynecological Oncology

Ciro Comparetto, Florence Dupré, Franco Borruto
Received: July 15, 2019; Published: December 12, 2019; doi:10.21926/obm.genet.1904101

Abstract: Background: Clinical or medical genetics deals with the study and diagnosis of genetic diseases. It is oriented to the formulation of the clinical diagnosis of genetic diseases and genetic counseling, in order to evaluate the possible reproductive risk for the patient and his family. The geneticist [...]

31 307

Open Access Hypothesis

Combination of the Hansemann-Boveri, Warburg, and Knudson Theories of Cancer, Based on Failure of Missegregation Damage Mitigation

Kjeld C. Engvild
Received: July 17, 2019; Published: December 3, 2019; doi:10.21926/obm.genet.1904100

Abstract: The Hansemann-Boveri aneuploidy theory, the Warburg aerobic glycolysis theory, and the Knudson two-hit mutation theory can be seen as different aspects of a theory where the very common chromosome missegregation damage is mitigated by several quite different mechanisms. Cancer only occurs when all o [...]

37 305

Open Access Review

Nutrition, Cancer Genetics and Epigenetics

Kenneth Lundstrom
Received: October 1, 2019; Published: November 28, 2019; doi:10.21926/obm.genet.1904099

Abstract: A strong association has been established between nutrition and disease risk confirmed by epidemiological data and meta-analysis. In the context of cancer, unhealthy diets have been demonstrated to increase the risk of disease. On the other hand, major dietary interventions and lifestyle changes hav [...]

36 313

Open Access Original Research

Diversity in the Bacterial Genus Dickeya Grouping Plant Pathogens and Waterways Isolates

Jacques Pédron, Frédérique Van Gijsegem
Received: July 25, 2019; Published: November 26, 2019; doi:10.21926/obm.genet.1904098

Abstract: Background: The Dickeya genus comprises aggressive soft rot plant pathogens with wide geographic distribution and host ranges. Ten Dickeya species have been characterised. Seven of them (D. chrysanthemi, D. dadantii, D. dianthicola, D. fangzhongdai, D. solani, D. paradisiaca, D. zeae) group causati [...]

42 324

Open Access Review

Optimizing Phage Translation Initiation

Xuhua Xia
Received: June 9, 2019; Published: October 17, 2019; doi:10.21926/obm.genet.1904097

Abstract: Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiatio [...]

45 385

Open Access Review

Insulin-Like Growth Factor 2 in Physiology, Cancer, and Cancer Treatment

Bas T Röttgering, Karoly Szuhai
Received: May 14, 2019; Published: October 14, 2019; doi:10.21926/obm.genet.1904096

Abstract: IGF2 is a strongly mitogenic peptide and imprinted gene primarily involved in foetal development. In the foetus, IGF2 is highly expressed and is involved with foetal growth and tissue differentiation. However, postnatally IGF2 expression decreases although its expression level is still higher in blo [...]

50 403

Open Access Short Report

Thalassemia Intermedia Caused by a Combination of a Globin Gene Triplication with Heterozygosity for β0 Thalassemia: A Case Report

Konstantinos Manganas, Sophia Delicou, Aikaterini Xydaki, Zoi Pallantza
Received: May 19, 2019; Published: September 17, 2019; doi:10.21926/obm.genet.1903095

Abstract: Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt hemoglobin synthesis. Thalassemia intermediate is referred to a group of disorders with a less severe form of the disease when compared with thalassemia major. We present the case of a 60 year old w [...]

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Open Access Editorial

Introduction to Genetic Screening

Johanne Traeger-Synodinos, François Rousseau
Received: September 6, 2019; Published: September 11, 2019; doi:10.21926/obm.genet.1903094

Abstract: We present here the content and articles of this special issue on genetic screening, putting them in perspective with the field and between themselves.

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