by OBM Genetics Editorial Office

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/obm.genet.2101122

by Shuji Takabayashi  , Takuya Aoshima  , Yukari Kobayashi  , Hisayoshi Takagi  , Eri Akasaka  and Masahiro Sato

Received: 23 September 2020;  Published: 03 December 2020;  doi: 10.21926/obm.genet.2004121

Improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) was developed for in situ genome editing of the preimplantation embryos present within the oviductal lumen of mice. This method is based on intra-oviductal instillation of genome editing components and subsequent in vivo electrop [...]

by Laura Privalle  , Patricia Back  , Apurv Bhargava  , Zach Bishop  , Krystal Cisneros  , Isabelle Coats  , Ine Criel  , Lien Dhondt  , Travis Draughn  , Barb Fowler  , Brad Franklin  , Durba Ghoshal  , Jim Lor  , Jennifer Massengil  , Sofie Moens  , Tyson Mooney  , Dannyel Nelson  , Karolien Peeters  , Sashi Sathischyandra  , Caroline Staut  , Yoonhui Sung  , Ann Tuttle  , Annelies Van Hoecke  , Annelies Van Raemdonck  , Marie-Laure Verdegem  , Steven Verhaeghe  , Shane Walsh  , Ann Wierckx  , Qiang Zhao  and Rozemarijn Dreesen

Received: 11 September 2020;  Published: 02 December 2020;  doi: 10.21926/obm.genet.2004120

Demonstration of the stability of traits newly introduced into a plant genome via genetic engineering approaches comprise a significant portion of the safety assessment that these products undergo prior to receiving the requisite regulatory approvals enabling commercial authorization. Different regi [...]

by Shingo Nakamura  , Naoko Ando  , Masayuki Ishihara  and Masahiro Sato

Received: 09 August 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004119

The liver is a major organ with a wide range of functions, including detoxification, protein synthesis, and bile production. Liver dysfunction causes liver diseases such as hepatic cirrhosis and hepatitis. To explore the pathogenesis of these liver diseases, and the therapeutic agents against them, [...]

by Montse Bach-Elias  and Mariette Kokolo

Received: 25 June 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004118

Non-coding RNAs (ncRNAs) have emerged as one of the most abundant regulatory molecules. However, their roles and functions are significantly different from those of proteins. Moreover, around 95% of the human genome contains non-coding DNA. ncRNAs contribute by far the majority of human transcriptio [...]

by Mary Lotesto  and Stacey Raimondi

Received: 26 June 2020;  Published: 07 October 2020;  doi: 10.21926/obm.genet.2004117

Estrogen-based cancers affect a substantial portion of the female population in the United States. While multiple studies have examined the effect of estrogen receptor alpha (ERα/ESR1) in cancer, the effects of ERβ/ESR2 are not as well understood in tumor tissues. Furthermore, there are few studies [...]

by Jiankang Jin  , Shumei Song  and Jaffer A. Ajani

Received: 30 June 2020;  Published: 16 September 2020;  doi: 10.21926/obm.genet.2003116

Gastric adenocarcinoma (GAC) is among the three most common cancers in the world. The majority of GAC patients are diagnosed in an advanced stage and have a median survival of ~9 months. There are limited effective therapeutic strategies available in the clinic and currently U.S. Food and Drug Admin [...]

by Fawzy Georges

Received: 21 April 2020;  Published: 13 August 2020;  doi: 10.21926/obm.genet.2003115

The challenges which face the world today can be summed up in a few words: An increasingly congested world with dwindling areas of viable cultivated land and accelerating climate instability. The combined effect of these realities, together with the trend of striving to extend the average human life [...]

by Ugo Testa  , Germana Castelli  and Elvira Pelosi

Received: 27 May 2020;  Published: 06 August 2020;  doi: 10.21926/obm.genet.2003114

Cancer is characterized by sequential and progressive genetic and epigenetic alterations in key proto-oncogenes and tumor suppressor genes, which ultimately lead to tumor development. Advances in the technology of analysis of molecular mechanisms have increased the efficiency of clinical management [...]

by Steve Liebich

Received: 16 March 2020;  Published: 02 July 2020;  doi: 10.21926/obm.genet.2003113

Multicellularity has gained the advantage over the unicellular world by expanding the number of increasingly more complex tissues that achieve advanced and specific functions. This same event gave rise to the most evolved group of organisms, namely mammals. Even though the complexity of multicellula [...]