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Open Access Review

Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5

Ian Macreadie, Sudip Dhakal
Received: May 05, 2019; Published: July 17, 2019; doi:10.21926/obm.geriatr.1903064

Abstract: The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided many insights into molecular and cellular biology, as well as insights into many human diseases. In this paper we present some insights on how yeast studies are contributing to knowledge about the role of oxidative damage to cel [...]

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Mario D. Garrett
Received: June 12, 2019; Published: July 16, 2019; doi:10.21926/obm.geriatr.1903063

Abstract: Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a centur [...]

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Tracy Harwood, John Maltby, Elizabeta B. Mukaetova-Ladinska
Received: March 28, 2019; Published: July 15, 2019; doi:10.21926/obm.geriatr.1903062

Abstract: Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia bene [...]

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Yoko Moriyama, Timothy Bolt, Marilyn Luptak, Nanako Tamiya
Received: February 19, 2019; Published: July 09, 2019; doi:10.21926/obm.geriatr.1903061

Abstract: Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on shor [...]

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Pavel Kalvach, Martin Vogner
Received: March 30, 2019; Published: July 08, 2019; doi:10.21926/obm.geriatr.1903060

Abstract: Our understanding of the mental deterioration associated with old-age have undergone a number of changes over the past two centuries and have spurred major scientific debates. In the 19th century, this disorder was still considered to be an inevitable feature of aging. The dawn of the 20th century o [...]

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Omid Ranjbar Pouya, Ahmad Byagowi, Debbie M. Kelly, Zahra Moussavi
Received: August 20, 2018; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902059

Abstract: Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) [...]

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Niklas Gudowsky, Ulrike Bechtold, Leo Capari, Mahshid Sotoudeh
Received: January 31, 2019; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902058

Abstract: (1) Background: In the light of recent changes in the discourse on positive ageing approaches, we take a closer look at the way “quality ageing” is understood, expressed and dealt with in technology assessment (TA) that investigates desirable frameworks and futures for an ageing society from a citiz [...]

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Joseph S. D'Arrigo
Received: December 27, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902057

Abstract: Much evidence has been reported which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorpor [...]

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Michael Chapman, Jennifer Philip, Paul Komesaroff
Received: December 20, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902056

Abstract: Alzheimer’s Disease is increasingly seen as the major health in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The perva [...]

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Terence Seedsman
Received: January 29, 2019; Published: May 24, 2019; doi:10.21926/obm.geriatr.1902055

Abstract: The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Research inv [...]

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