Table of Content

Open Access Review

Alzheimer’s Disease: Is a Dysfunctional Mevalonate Biosynthetic Pathway the Master-Inducer of Deleterious Changes in Cell Physiology?

Arnold De Loof, Liliane Schoofs
Received: October 03, 2019; Published: November 29, 2019; doi:10.21926/obm.neurobiol.1904046

Abstract: The awareness is growing that the proteins amyloid-beta (Aβ) and tau are rather a result of Alzheimer’s disease (AD) than its cause. Similarly, doubt reigns about the degree of causality of high plasma cholesterol/lipids (the fat connection) and of prenylation. An important conceptual addition to [...]

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Open Access Research Article

Relationship between Brain Injury and Clinical Biomarkers in Hypoxic-Ischemic Newborn Piglets

Francisco J Alvarez, Antonia A. Alvarez, Hector Lafuente, Daniel Alonso-Alconada, Jose L. Blanco-Bruned, Francisco Santaolalla, Enrique Hilario
Received: June 24, 2019; Published: November 15, 2019; doi:10.21926/obm.neurobiol.1904045

Abstract: (1) Background: Newborn affected by hypoxic-ischemic brain injury can die and the survivors suffer neurodevelopmental handicaps. Biomarkers are needed to identify the severity of hypoxic-ischemic insult in order to early determine the rescue treatment. The aim of this study was to correlate the path [...]

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Open Access Research Article

The Relationship between Sleep Quality and Eating Competence in A Sample of Canadian Post-Secondary Students

E. Papaconstantinou, V. Quick, E. Vogel, S. Coffey
Received: August 09, 2019; Published: October 31, 2019; doi:10.21926/obm.neurobiol.1904044

Abstract: Background: Post-secondary students are at increased risk for sleep problems and poor eating behaviours that overtime may lead to negative health outcomes later in life. However, limited research has examined associations of sleep quality with eating behaviours and eating competence (e.g., being pos [...]

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Open Access Original Research

Acute Exercise on Reversal Learning

Claire Sanderson, Paul D. Loprinzi
Received: July 15, 2019; Published: October 09, 2019; doi:10.21926/obm.neurobiol.1904043

Abstract: Objective: Reversal learning requires an individual to alter their behavior when previously learned reward-based contingencies are reversed. Reversal learning is heavily influenced by cognitive flexibility, which has been shown to be enhanced with acute exercise. However, minimal work has directly e [...]

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Open Access Review

Transcranial Magnetic Stimulation: A Tool for Quantifying Neurophysiological Changes in the Brain Following Concussion Injury in Sports

Alan J Pearce
Received: July 05, 2019; Published: September 27, 2019; doi:10.21926/obm.neurobiol.1903042

Abstract: (1) Background: Sport-related concussion is a growing public health concern. Defined as a functional injury, concussion is characterised by a constellation of signs and symptoms. However, clinical imaging methods do not reveal any structural damage. Recently, neurophysiological techniques such as tr [...]

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Open Access Research Article

The End Effector of Ischemic Tolerance Present in Blood Plasma from Double Conditioned Donors Ameliorates Trimethyltin Provoked Damage in Brain

Rastislav Burda, Viera Danielisová, Jozef Burda
Received: July 03, 2019; Published: September 20, 2019; doi:10.21926/obm.neurobiol.1903041

Abstract: Background: Hundreds of experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. The translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-methyltin poi [...]

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Open Access Review

Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases

Joseph S. D'Arrigo
Received: August 22, 2019; Published: September 16, 2019; doi:10.21926/obm.neurobiol.1903040

Abstract: Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

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Open Access Review

Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Siavash Jafari, Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, Ashkan Nasr
Received: August 11, 2019; Published: September 09, 2019; doi:10.21926/obm.neurobiol.1903039

Abstract: Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

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Open Access Review

Hyperglycemia-Induced Brain Injury in Preterm Infants

Katherine Satrom, Tate Gisslen, Raghavendra Rao
Received: May 29, 2019; Published: August 29, 2019; doi:10.21926/obm.neurobiol.1903038

Abstract: Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...]

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Open Access Review

Extra Corporeal Life Support in Traumatic Brain Injury Patients

Berta Monleón López, Valentina Della Torre, Federico Bilotta, Rafael Badenes
Received: June 11, 2019; Published: August 22, 2019; doi:10.21926/obm.neurobiol.1903037

Abstract: Purpose of review: The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The charac [...]

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