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Open Access Original Research

Acute Exercise on Reversal Learning

Claire Sanderson, Paul D. Loprinzi
Received: July 15, 2019; Published: October 09, 2019; doi:10.21926/obm.neurobiol.1904043

Abstract: Objective: Reversal learning requires an individual to alter their behavior when previously learned reward-based contingencies are reversed. Reversal learning is heavily influenced by cognitive flexibility, which has been shown to be enhanced with acute exercise. However, minimal work has directly e [...]

Open Access Review

Transcranial Magnetic Stimulation: A Tool for Quantifying Neurophysiological Changes in the Brain Following Concussion Injury in Sports

Alan J Pearce
Received: July 05, 2019; Published: September 27, 2019; doi:10.21926/obm.neurobiol.1903042

Abstract: (1) Background: Sport-related concussion is a growing public health concern. Defined as a functional injury, concussion is characterised by a constellation of signs and symptoms. However, clinical imaging methods do not reveal any structural damage. Recently, neurophysiological techniques such as tr [...]

Open Access Research Article

The End Effector of Ischemic Tolerance Present in Blood Plasma from Double Conditioned Donors Ameliorates Trimethyltin Provoked Damage in Brain

Rastislav Burda, Viera Danielisová, Jozef Burda
Received: July 03, 2019; Published: September 20, 2019; doi:10.21926/obm.neurobiol.1903041

Abstract: Background: Hundreds of experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. The translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-methyltin poi [...]

Open Access Review

Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases

Joseph S. D'Arrigo
Received: August 22, 2019; Published: September 16, 2019; doi:10.21926/obm.neurobiol.1903040

Abstract: Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

Open Access Review

Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Siavash Jafari, Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, Ashkan Nasr
Received: August 11, 2019; Published: September 09, 2019; doi:10.21926/obm.neurobiol.1903039

Abstract: Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

Open Access Review

Hyperglycemia-Induced Brain Injury in Preterm Infants

Katherine Satrom, Tate Gisslen, Raghavendra Rao
Received: May 29, 2019; Published: August 29, 2019; doi:10.21926/obm.neurobiol.1903038

Abstract: Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...]

Open Access Review

Extra Corporeal Life Support in Traumatic Brain Injury Patients

Berta Monleón López, Valentina Della Torre, Federico Bilotta, Rafael Badenes
Received: June 11, 2019; Published: August 22, 2019; doi:10.21926/obm.neurobiol.1903037

Abstract: Purpose of review: The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The charac [...]

Open Access Original Research

Characterisation of Oxidative Stress, DNA Damage and Inflammation in a Cellular Model of Parkinson’s Disease

Alina Khan, Tengfei Wan, Catherine Hunter, Pavel Schweizer, Abbas Ishaq, Shobha Nagarathanam, Julia Morris, Minyu Chan, Gabriele Saretzki
Received: March 13, 2019; Published: August 01, 2019; doi:10.21926/obm.neurobiol.1903036

Abstract: Background: Parkinson’s disease (PD) is the second most commonly occurring neurodegenerative disease and is classed as a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage. Methods: SH- [...]

Open Access Review

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Hideki Kanamaru, Fumihiro Kawakita, Reona Asada, Hidenori Suzuki
Received: May 07, 2019; Published: July 29, 2019; doi:10.21926/obm.neurobiol.1903035

Abstract: Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury and the mechanisms have not been completely found out yet. The causative factors of brain injury initiated by aneurysm rupture, which is called as early brain injury (EBI), consists of elevated intracranial pressure, cerebral hypo [...]

Open Access Review

Short Sleep in Pupils in Japan: Current Status and Associated Factors

Jun Kohyama
Received: February 21, 2019; Published: July 22, 2019; doi:10.21926/obm.neurobiol.1903034

Abstract: Background: Japan is the most sleepless nation in the world. This study aimed to understand short sleep pupils in Japan. Since academic performance is known to worsen with sleep problems, self-reported academic performance (s-rAP) was also investigated. Methods: A total of 1766 completed questionna [...]

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