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Open Access Review

Therapeutic Strategies and Current Management for Hepatic Encephalopathy in Liver Cirrhosis

Kazuyuki Suzuki, Akinobu Kato, Yasuhiro Takikawa
Received: February 04, 2019; Published: July 16, 2019; doi:10.21926/obm.hg.1903027

Abstract: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minim [...]

Open Access Review

Review of Current Evidence in Acute Pancreatitis

Samantha Varley, Kirsten Rossi, Meghan Murray, Alissa Nichole
Received: May 17, 2019; Published: July 12, 2019; doi:10.21926/obm.hg.1903026

Abstract: Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stone [...]

Open Access Review

Nonalcoholic Fatty Liver Disease and Inflammatory Bowel Disease: Complex Interactions, Evaluations, and Management Decisions

Brett Sadowski, Sarah Ordway, Kevin Bobeck, Adam Tritsch, Manish Singla
Received: January 31, 2019; Published: June 28, 2019; doi:10.21926/obm.hg.1902025

Abstract: Diseases of the liver are commonly encountered in patients with Inflammatory Bowel Disease (IBD). While the differential for IBD patients with elevated liver associated enzymes is broad, it is similar to that of the general population. This differential includes including non-alcoholic fatty liver d [...]

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Richell Booijink, Ruchi Bansal
Received: March 27, 2019; Published: June 21, 2019; doi:10.21926/obm.hg.1902024

Abstract: Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of [...]

Open Access Review

Zinc in Liver Fibrosis

Kurt Grüngreiff , Thomas Gottstein, Dirk Reinhold
Received: March 15, 2019; Published: June 13, 2019; doi:10.21926/obm.hg.1902023

Abstract: Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connect [...]

Open Access Review

Managing Acute Severe Necrotising Pancreatitis

Michal Kawka, Tamara MH Gall, Long R Jiao
Received: February 25, 2019; Published: June 05, 2019; doi:10.21926/obm.hg.1902022

Abstract: Background: Severe necrotising pancreatitis (SNP) is characterised by high mortality, severe complications and bad prognosis despite progress in understanding of aetiology and progression of the disease. Traditionally, necrotic changes were removed by open necrosectomy but the paradigm has shifted t [...]

Open Access Opinion

The Curing of Crohn’s Disease

Gilles R. G. Monif
Received: January 06, 2019; Published: June 04, 2019; doi:10.21926/obm.hg.1902021

Abstract: Using the therapeutic intervention points identified by the Hruska Postulate, the probability of curing Crohn’s disease through destroying the anti-MAP template is discussed.

Open Access Research Article

NF-κB; the Critical Link between Immune and Metabolic Pathways: Could NF-κB be Used as a Novel Diagnostic and Prognostic Biomarker for Non-Alcoholic Steatohepatitis?

Athina Chasapi , Konstantinos Balampanis, Anna Tanoglidi, Eleni Kourea, George I. Lambrou, Vaia Lambadiari, Fotios Kalfarentzos, Erifili Hatziagelaki, Maria Melachrinou, Georgia Sotiropoulou-Bonikou
Received: January 28, 2019; Published: May 22, 2019; doi:10.21926/obm.hg.1902020

Abstract: (1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or [...]

Open Access Review

Organotin Polymers for the Control of Pancreatic Cancer

Charles E. Carraher, Jr., Michael R. Roner, Jessica Frank, Paul Slawek, Francesca Mosca, Kimberly Shahi, Alisa Moric-Johnson, Lindsey Miller
Received: January 31, 2019; Published: May 14, 2019; doi:10.21926/obm.hg.1902019

Abstract: Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epit [...]

Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Masaaki Takamura, Shuji Terai
Received: February 4, 2019; Published: April 25, 2019; doi:10.21926/obm.hg.1902018

Abstract: In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body flu [...]

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