Table of Content

Open Access Review

Platelet Function in Experimental Models of Liver Cirrhosis

Paola Romecín, Joaquín García-Estañ, Noemí M. Atucha
Received: May 15, 2019; Published: November 01, 2019; doi:10.21926/obm.hg.1904039

Abstract: (1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of f [...]

10 94

Open Access Case Report

Primary Pancreatic-Type Acinar Cell Carcinoma of Jejunum Arising from Ectopic Pancreas with Synchronous Metastasis to Left Adrenal Gland

Oliver H. Wang, Priya R. Bhosale, Jeannelyn S. Estrella
Received: July 08, 2019; Published: October 28, 2019; doi:10.21926/obm.hg.1904038

Abstract: Background: Pure pancreatic-type ACC outside the pancreas is extremely rare. Methods: We presented a very rare case of primary ACC of the pancreatic-type involving jejunum with a synchronous metastasis to left adrenal gland arising in well-developed ectopic pancreas which had fully developed pancre [...]

12 78

Open Access Case Report

Partial Response of Alopecia Areata to Helicobacter Pylori Eradication and Treatment with Low-Dose Naltrexone

Laura Alonso Canal, María José Quiles Blanco, David Jiménez Leiva, María José González Iglesias
Received: June 26, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903037

Abstract: Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The i [...]

18 165

Open Access Perspective

Missing the Target to Treat in Crohn’s Disease

Herbert Van Kruiningen
Received: April 05, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903036

24 193

Open Access Case Report

Secondary Acute Pancreatitis Associated with Paracetamol and Codeine Administration after Dental Treatment: Literature Analysis and Clinical Case Study

Alessandro Luigi Rossi, Vincenzo Capilupi, David Palombo, Luigi Tagliatesta, Tecla Terenzio, Marco Vitali, Matteo Chiapasco
Received: April 29, 2019; Published: August 30, 2019; doi:10.21926/obm.hg.1903035

Abstract: OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS A [...]

31 278

Open Access Review

Rare Causes of Acute Pancreatitis: Drugs, Eosinophilia, and Autoimmunity

Mauro Turrin
Received: March 15, 2019; Published: August 29, 2019; doi:10.21926/obm.hg.1903034

Abstract: Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February [...]

32 309

Open Access Review

Advanced Endoscopic Techniques in the Evaluation and Treatment of Fibrostenotic Crohn's Disease

Alina Wong, Scott D Lee
Received: May 09, 2019; Published: August 16, 2019; doi:10.21926/obm.hg.1903033

Abstract: Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring [...]

30 319

Open Access Review

Conventional and Future Therapies for Crohn's Disease

Abdulmaleek Sado, Rahul Kalla, Simon Campbell
Received: May 20, 2019; Published: August 14, 2019; doi:10.21926/obm.hg.1903032

Abstract: Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications [...]

27 414

Open Access Review

New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Rachel Rutherford, Patrick B Allen
Received: February 25, 2019; Published: August 12, 2019; doi:10.21926/obm.hg.1903031

Abstract: Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting [...]

31 352

Open Access Review

Pathological Angiogenesis: The New Culprit behind Chronic Liver Disease

Marta Ramirez, Mercedes Fernandez
Received: February 25, 2019; Published: July 31, 2019; doi:10.21926/obm.hg.1903030

Abstract: This review describes our current understanding of the pathogenic role of angiogenesis in chronic liver disease and portal hypertension, emphasizing its involvement not only in the liver but also in extrahepatic complications such as the formation of portosystemic collaterals and increased splanchni [...]

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