Table of Content

Open Access Review

The Effects of Mediterranean Diet on the Human Gut Microbiota; a Brief Discussion of Evidence in Humans

Received: 09 November 2020;  Published: 05 February 2021;  doi: 10.21926/obm.hg.2101056


The Mediterranean diet (MD) is considered one of the healthiest dietary patterns due to its rich provision of phytochemicals, antioxidants, vitamins, fiber, polyunsaturated, omega-3, and short-chain fatty acids through a variety of foods. The supply of such nutrients and bioactive components can sup [...]

33 191

Open Access Commentary

Deconstructing then Priming Gut Microbiota Resilience

Received: 11 December 2020;  Published: 01 February 2021;  doi: 10.21926/obm.hg.2101055


The human intestinal microbiota represents a complex microbial community that plays an essential role in the maintenance of host health. Over the last decade, metagenomic and metabolomic analyses have revealed the influence of intestinal microbial diversity and composition on a range of biological f [...]

49 384

Open Access Editorial

Acknowlegement to Reviewers of OBM Hepatology and Gastroenterology in 2020

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.hg.2101054


The editors of OBM Hepatology and Gastroenterology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer [...]

53 233

Open Access Original Research

Multi-Species Probiotic Modulates Cytokine Production and the Interplay between Immune and Colon Cancer Cells

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053


The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1 [...]

115 590

Open Access Review

The Physiology of Esophageal Reflexes

Received: 17 August 2020;  Published: 02 November 2020;  doi: 10.21926/obm.hg.2004052


Several digestive tract reflexes involving the esophagus and its sphincter muscles have been identified, but to date, no comprehensive review has addressed most of these reflexes. The current review presents the known physiology of different esophageal reflexes in which either the esophagus or its s [...]

149 507

Open Access Case Report

Porto-Sinusoidal Vascular Disease with Obliterative Portal Venopathy Associated with Long-Term Azathioprine for Crohn’s Disease

Received: 04 March 2020;  Published: 25 September 2020;  doi: 10.21926/obm.hg.2003051


Patients receiving immunosuppressive therapy for inflammatory bowel disease may be susceptible to non-cirrhotic portal hypertension, now referred to as porto-sinusoidal vascular disease. Here we describe a patient treated with long-term azathioprine for Crohn’s disease who developed porto-sinusoidal [...]

146 607

Open Access Review

Human Gut Microbiota: Friend or Foe?

Received: 06 March 2020;  Published: 07 August 2020;  doi: 10.21926/obm.hg.2003050


The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Simila [...]

270 852

Open Access Review

Use of Organs from Hepatitis C Viremic Donors: Addressing the Needs of a Changing Waitlist and the Effect of a Public Health Crisis

Received: 14 May 2020;  Published: 20 July 2020;  doi: 10.21926/obm.hg.2003049


The combination of broad screening initiatives and development of effective antiviral therapies have led to a revolution in the treatment of hepatitis C virus and has reduced the proportion of patients with the virus who develop a need for liver transplantation in favor of other etiologies, such as [...]

220 728

Open Access Original Research

Prevalence of Chronic Constipation and Irritable Bowel Syndrome, and their Overlap, among Female Undergraduate Students in Japan

Received: 10 April 2020;  Published: 19 May 2020;  doi: 10.21926/obm.hg.2002048


Chronic constipation and irritable bowel syndrome (IBS) are two of the most common functional gastrointestinal disorders, both of which negatively affect the quality of life of the patients. Since people may have co-existing symptoms of multiple disorders, chronic constipation and IBS with predomina [...]

209 1029

Open Access Original Research

Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047


Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hypergl [...]

203 1012