Table of Content

Open Access Editorial

Geriatric Cardiac Diseases

Giuseppe Cocco
Received: March 20, 2020; Published: April 01, 2020; doi:10.21926/obm.geriatr.2002112

31 209

Open Access Review

Known–Unknowns in Geriatric Cardiology

Giuseppe Cocco, Philipp Amiet
Received: February 05, 2020; Published: March 19, 2020; doi:10.21926/obm.geriatr.2001111

Abstract: The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly pa­tients dealing with the prevention of arte [...]

42 308

Open Access Review

Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways

Joseph S. D'Arrigo
Received: December 26, 2019; Published: February 28, 2020; doi:10.21926/obm.geriatr.2001110

Abstract: Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. [...]

32 344

Open Access Review

Dysphagia and Oral Health in Older People

Sima Farpour, David Smithard, Hamid Reza Farpour
Received: November 14, 2019; Published: February 20, 2020; doi:10.21926/obm.geriatr.2001109

Abstract: Dysphagia is a term that is used for the difficulty in moving liquid/food from mouth to the stomach. Dysphagia is very common in elders, which makes them susceptible to malnutrition, infection, institutionalization, and death. Consequently, it is categorized as a geriatric syndrome. Therefore, multi [...]

51 398

Open Access Original Research

Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial

Akemi Hirano, Yusuke Suzuki, Hiroyuki Umegaki, Toshio Hayashi, Koichiro Ina, Joji Onishi, Jun Hasegawa, Masafumi Kuzuya
Received: October 13, 2019; Published: February 19, 2020; doi:10.21926/obm.geriatr.2001108

Abstract: The incidence of vascular diseases among caregivers of dementia patients is high, and one potential cause is the exacerbation of blood coagulability due to mental strain from caregiving. This study aimed to examine the effects of aerobic exercise on blood coagulability, from the perspective of impro [...]

41 394

Open Access Short Review

Alzheimer's Disease: Parsing the Pathways Leading to the Disease Based on the Spirochete/Biofilm Hypothesis

Herbert B. Allen
Received: December 31, 2019; Published: February 19, 2020; doi:10.21926/obm.geriatr.2001107

Abstract: A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. Th [...]

44 377

Open Access Review

Problems Associated with the Measurement of Neuropsychiatric Symptoms of Dementia

Natalie G. Regier
Received: December 04, 2019; Published: February 17, 2020; doi:10.21926/obm.geriatr.2001106

Abstract: Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfor [...]

36 403

Open Access Review

Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease

Marcel Ruiz-Mejias, Patricia Castano-Prat, Tony Donegan, Maria V. Sanchez-Vives
Received: December 31, 2019; Published: February 14, 2020; doi:10.21926/obm.geriatr.2001105

Abstract: Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) eme [...]

42 468

Open Access Review

Behaviors of Persons with Dementia: A Review and New Perspective for Future Research

Morgan J. Minyo, Katherine S. Judge
Received: July 30, 2019; Published: February 07, 2020; doi:10.21926/obm.geriatr.2001104

Abstract: Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review cons [...]

42 778

Open Access Perspective

Target Tau, not Amyloid, to Prevent and Treat Alzheimer’s Disease

Margaret M Esiri
Received: November 17, 2019; Published: February 04, 2020; doi:10.21926/obm.geriatr.2001103

Abstract: In this article I wish to put the case for a change of emphasis in the approach to finding a prevention/treatment for Alzheimer’s disease from a focus on beta amyloid to one on tau. In particular, I make the case for aiming to prevent the spread of abnormal tau from the medial temporal lobe to wides [...]

54 448

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