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Open Access Review

Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and Hostility

Lei Zhang, Xian-Zhang Hu, Xiaoxia Li, Jacob Dohl, Tianzheng Yu, Robert J. Ursano
Received: December 28, 2018; Published: March 21, 2019; doi:10.21926/obm.geriatr.1901041

Abstract: Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to [...]

Open Access Review

Does Dementia Increase the Risk of Dental Decay?

Robert J Emanuel
Received: January 09, 2019; Published: March 21, 2019; doi:10.21926/obm.geriatr.1901040

Abstract: The amount of patients who suffer with dementia is set to rise with an ageing population living longer. As well as living longer, patients will be retaining their natural teeth longer and will be less reliant on dentures. From both the current evidence available in the literature, and anecdotally [...]

Open Access Perspective

Behavioural and Complementary Interventions for Healthy Neurocognitive Aging

Robert L. Conder, Jr., Christopher Friesen, Alanna A. Conder
Received: November 30, 2018; Published: March 20, 2019; doi:10.21926/obm.geriatr.1901039

Abstract: Background: While the percent of persons 65 and older is expected to increase to 17% of the world’s population by 2050, this increase in longevity does not necessarily suggest a parallel increase in health status. While aging is an inevitable aspect of living, there are factors which can accelerate [...]

Open Access Original Research

Prediction of ADRs and Estimation of Polypharmacy in Older Patient’s Population: Retrospective Study in Russian Gerontology Center

Ali Al-Ragawi, Sergey Zyryanov, Elena Ushkalova, Olga Butranova, Anton Pereverzev
Received: October 10, 2018; Published: March 05, 2019; doi:10.21926/obm.geriatr.1901038

Abstract: Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. There have been limited studies in detecting adverse effects in patients admitting hospitals. Objective: Prediction of ADR in patients ≥ 65 years old, based on GerontoNet ri [...]

Open Access Original Research

Exploring the Paradox of Care: Differences in Older Adult and Proxy Ratings of Health and Subjective Well-Being

Kristopher M. Struckmeyer, Alex J. Bishop, Brenda J. Smith, Brandt C. Gardner
Received: August 27, 2018; Published: February 27, 2019; doi:10.21926/obm.geriatr.1901037

Abstract: (1) Background: The purpose of this study was to examine discrepancies in self-proxy agreement of biopsychosocial factors and the influence of objective well-being and psychosocial resources influence self and proxy appraisals of subjective well-being in older care recipients. (2) Methods: Seventy-t [...]

Open Access Technical Note

Improving the HealthCare of People with Dementia beyond the Diagnosis: The “Carlo Poma Dementia Care Pathway” Study Protocol

Vincenza Frisardi, Sara Faroni, Angela Bellani, Felice Biagi, Emanuela Galante, Alida Balzanelli, Erika Talassi, Lorella Frittoli, Giancarla Capiluppi, Claudia D’angelis, Antonella Taragnani, Donatella Terzi, Elena Podavini, Graziana Gazzoni, Graziana Simoncelli, Carmine Matarazzo, Mirko Avesani, Antonio Ventura, Consuelo Basili, Maurizio Galavotti, Carlo Maria Stucchi, Maria Cristina Cilia, Alfonso Ciccone
Received: October 31, 2018; Published: February 27, 2019; doi:10.21926/obm.geriatr.1901036

Abstract: The WHO global action plan on the public health response to dementia 2017-2025 stressed the concept about the need to have a comprehensive approach with deep interconnections and crosscutting elements through several action areas. As the elderly population grows worldwide, the number of patients wit [...]

Open Access Hypothesis

Sporadic Alzheimer Disease and That Developing in Down’s Syndrome: The Immune System Attacking Self Rather Than Suppressing Infectious Disease Invaders, Toll Like Receptors Triggering Excessive Cytosolic Calcium, Excess Calcineurin Activation, Overexpress

Steven R. Brenner
Received: August 29, 2018; Published: February 26, 2019; doi:10.21926/obm.geriatr.1901035

Abstract: Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloi [...]

Open Access Review

Cell Senescence, Telomerase, and Senolytic Therapy

Michael Fossel
Received: December 31, 2018; Published: February 15, 2019; doi:10.21926/obm.geriatr.1901034

Abstract: The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable [...]

Open Access Research Article

Effect of Six-Months Supplementation with Cholecalciferol on Glycemic and Blood Pressure Control in Elderly Type 2 Diabetic Patients with Vitamin D Deficiency: A Pilot Study

Marco Barale, Ruth Rossetto Giaccherino, Ezio Ghigo, Massimo Procopio
Received: October 31, 2018; Published: February 14, 2019; doi:10.21926/obm.geriatr.1901033

Abstract: Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. The aim of our pilot study was to evaluate in uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D [...]

Open Access Research Article

Key Dimensions of Therapeutic Lies in Dementia Care: A New Taxonomy

Rachel Mills, Louisa Jackman, Mithila Mahesh, Ian James
Received: December 12, 2018; Published: February 12, 2019; doi:10.21926/obm.geriatr.1901032

Abstract: Background: Research suggests that the use of lies and deception is prevalent within dementia care settings, despite ongoing debates raised about the ethics of this approach. There has been increasing exploration of when and why deceptive practices should be used, but the lack of clarity as to what [...]

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