Table of Content

Open Access Review

Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Siavash Jafari, Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, Ashkan Nasr
Received: August 11, 2019; Published: September 09, 2019; doi:10.21926/obm.neurobiol.1903039

Abstract: Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

42 405

Open Access Review

Hyperglycemia-Induced Brain Injury in Preterm Infants

Katherine Satrom, Tate Gisslen, Raghavendra Rao
Received: May 29, 2019; Published: August 29, 2019; doi:10.21926/obm.neurobiol.1903038

Abstract: Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...]

43 412

Open Access Review

Extra Corporeal Life Support in Traumatic Brain Injury Patients

Berta Monleón López, Valentina Della Torre, Federico Bilotta, Rafael Badenes
Received: June 11, 2019; Published: August 22, 2019; doi:10.21926/obm.neurobiol.1903037

Abstract: Purpose of review: The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The charac [...]

45 474

Open Access Original Research

Characterisation of Oxidative Stress, DNA Damage and Inflammation in a Cellular Model of Parkinson’s Disease

Alina Khan, Tengfei Wan, Catherine Hunter, Pavel Schweizer, Abbas Ishaq, Shobha Nagarathanam, Julia Morris, Minyu Chan, Gabriele Saretzki
Received: March 13, 2019; Published: August 01, 2019; doi:10.21926/obm.neurobiol.1903036

Abstract: Background: Parkinson’s disease (PD) is the second most commonly occurring neurodegenerative disease and is classed as a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage. Methods: SH- [...]

65 713

Open Access Review

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Hideki Kanamaru, Fumihiro Kawakita, Reona Asada, Hidenori Suzuki
Received: May 07, 2019; Published: July 29, 2019; doi:10.21926/obm.neurobiol.1903035

Abstract: Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury and the mechanisms have not been completely found out yet. The causative factors of brain injury initiated by aneurysm rupture, which is called as early brain injury (EBI), consists of elevated intracranial pressure, cerebral hypo [...]

62 562

Open Access Review

Short Sleep in Pupils in Japan: Current Status and Associated Factors

Jun Kohyama
Received: February 21, 2019; Published: July 22, 2019; doi:10.21926/obm.neurobiol.1903034

Abstract: Background: Japan is the most sleepless nation in the world. This study aimed to understand short sleep pupils in Japan. Since academic performance is known to worsen with sleep problems, self-reported academic performance (s-rAP) was also investigated. Methods: A total of 1766 completed questionna [...]

39 533

Open Access Original Research

Melatonin Aggravated Oxaliplatin-Mimicking Sinusoidal Obstruction Syndrome: Role of Platelet Aggregation and Oxidative Stress

Srinivasan Periasamy, Se-Ping Chien, Bing-Fang Lee, Dur-Zong Hsu, Ming-Yie Liu 
Received: March 31, 2019; Published: July 17, 2019; doi:10.21926/obm.neurobiol.1903033

Abstract: (1) Background: Sinusoidal obstruction syndrome is a liver injury induced either by accidental ingestion of pyrrolizidine alkaloid monocrotaline or by chemotherapeutic drug oxaliplatin used for the treatment of colorectal cancer. Sinusoidal obstruction syndrome is characterized by rounding and swell [...]

70 584

Open Access Research Article

Daytime Sleepiness and the Well-Being and Academic Attainment of University Students in the UK

Kate Howells, Andrew P. Smith
Received: April 02, 2019; Published: July 02, 2019; doi:10.21926/obm.neurobiol.1903032

Abstract: Background: Previous research suggests that insufficient daily sleep has negative effects on both well-being and academic attainment. Much of the research in this field has focused on adolescents and children rather than university students in the UK. Methods: The present study used the Student Well [...]

66 639

Open Access Research Article

Autonomic Function Correlates with Microflora Compositions in a Small Cohort of Patients with Autism Spectrum Disorder: Preliminary Clinical Data and Discussion

Daniel Goyal, Fatma Mansab, James Neil, Jaleel Miyan
Received: March 05, 2019; Published: June 28, 2019; doi:10.21926/obm.neurobiol.1902031

Abstract: Research into the effects of microflora on health and in disease has increased recently. Such enthusiasm seems well placed. Should the preliminary studies translate through the larger, more powerful studies, the medical community may well have an entirely new platform from which to intervene for h [...]

58 570

Open Access Communication

A Neurotransmitter Approach to the Trolley Problem

Daniel Z. Lieberman, Sara Teichholtz, Brenna R. Emery
Received: Feburary 25, 2019; Published: June 28, 2019; doi:10.21926/obm.neurobiol.1902030

Abstract: Is it ethically permissible to sacrifice the life of one human being in order to save the lives of five others? This question forms the basis of the famous thought experiment called “the trolley problem.” Surveys have found that 90 percent of people agree it is permissible when the victim to be sacr [...]

74 526