Table of Content

Open Access Editorial

Editorial: “A New Era in Neuro-Oncology”

Antonio Meola
Received: May 05, 2019; Published: May 08, 2019; doi:10.21926/obm.neurobiol.1902025

53 323

Open Access Research Article

Gluten-Free Diet for the Treatment of ADHD; Pilot Study

Laura Alonso Canal, Inmaculada Carreras Sáez, María Concepción Fournier del Castillo, Julia Asensio Antón, Inmaculada de Prada Vicente, Carlos Isasi Zaragoza, Javier Tejada Gallego, María José Martínez Gómez
Received: December 17, 2018; Published: April 03, 2019; doi:10.21926/obm.neurobiol.1902024

Abstract: Aim: The association between Attention deficit hyperactivity disorder (ADHD) and celiac disease has already been established. Non-celiac gluten sensitivity (NCGS), as well as celiac disease, has been associated with neuro-psychiatric disorders. Our objective is to assess if a proportion of pediatric [...]

50 335

Open Access Review

Ischemic Brain Injury and Regulatory T Cells

Minako Ito, Tanakorn Srirat, Toshihiro Nakamura, Kyoko Komai, Akihiko Yoshimura
Received: January 13, 2019; Published: March 27, 2019; doi:10.21926/obm.neurobiol.1901023

Abstract: Inflammation and immune responses after stroke including ischemic cerebral infarction play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues [...]

66 425

Open Access Review

Diffuse Intrinsic Pontine Glioma: Translation of Genomic Knowledge to Clinical Practice

Tina Zhou, Sara Khan, Ron Firestein, Peter Downie, Jason E Cain
Received: November 29, 2018; Published: March 12, 2019; doi:10.21926/obm.neurobiol.1901022

Abstract: Pediatric brain tumors account for approximately 25% of all cancers in children and are currently the leading cause of cancer-related deaths in the pediatric population with an estimated incidence of 5.14 cases per 100,000 persons [1]. Up to 10-15% of all pediatric brain tumors arise in the brainste [...]

61 438

Open Access Review

Sporadic and Hereditary Hemangioblastoma: The Role of Endothelial Cells

Alberto Feletti, Elena Bianchini, Anna De Gaetano, Lara Gibellini, Sara De Biasi, Giacomo Pavesi, Anna Vittoria Mattioli, Milena Nasi, Andrea Cossarizza, Marcello Pinti
Received: November 26, 2018; Published: March 04, 2019; doi:10.21926/obm.neurobiol.1901021

Abstract: Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. About 75% of HBs are sporadic, while 25% are associated with von Hippel-Lindau (VHL) disease. HBs consist of two main components, a rich capillary network composed of vascular endothelia and pericytes, with [...]

54 347

Open Access Research Article

Magnetic Resonance Imaging Approaches for Predicting the Response to Hyperoxic Radiotherapy in Glioma-Bearing Rats

Nuria Arias-Ramos, Jesús Pacheco-Torres, Pilar López-Larrubia
Received: November 11, 2018; Published: January 31, 2019; doi:10.21926/obm.neurobiol.1901020

Abstract: Background: Despite the advances in multimodal therapeutic options, glioblastoma (GBM), the most frequent and aggressive of all astrocytomas, remains with a median survival of 15 months. It is reported a direct correlation between GBM hypoxia and a higher aggressiveness, poor prognosis and greater r [...]

47 428

Open Access Research Article

Correlation of CT and MR Perfusion and Permeability Parameters for Intracranial Tumors

Kirsten Greenlaw, Jai Jai Shiva Shankar
Received: October 7, 2018; Published: January 14, 2019; doi:10.21926/obm.neurobiol.1901019

Abstract: Background and Purpose: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating [...]

60 358

Open Access Case Report

Cerebellopontine Angle Glioblastoma with Concurrent Spinal Cord Involvement: A Case Report and Review of Literature

Rahul Abhyankar, Divya Mella, Edward Pan
Received: November 12, 2018; Published: January 4, 2019; doi:10.21926/obm.neurobiol.1901018

Abstract: Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebelloponti [...]

49 515

Open Access Review

Sleep Disorders in Children with Central Nervous System Tumors

Melissa A. Maloney, Katherine E. Lewinter, Sally L. Davidson Ward, Iris A. Perez
Received: November 13, 2018; Published: December 17, 2018; doi:10.21926/obm.neurobiol.1804017

Abstract: Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hy [...]

54 399

Open Access Original Research

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Michele Bisceglia, Stefano Pizzolitto, Tullio Parracino, Giovanna De Maglio, Elena Minenna, Serena D’Agostini, Carlos A. Galliani
Received: October 7, 2018; Published: November 14, 2018; doi:10.21926/obm.neurobiol.1804016

Abstract: Thyroid transcription factor 1 (TTF-1) is a nuclear polypeptide, tissue-restricted member of the homeobox protein family, that when attached to DNA plays a crucial role in regulating the expression of select genes during early embryonic development of the thyroid, lung, and brain. As often happens, [...]

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