Table of Content

Open Access Review

Sleep Dysfunction in Fibromyalgia and Therapeutic Approach Options

Received: 05 November 2019;  Published: 20 January 2020;  doi: 10.21926/obm.neurobiol.2001049

Abstract

Fibromyalgia, characterised by persistent pain, sleep disturbance, fatigue and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a [...]

84 1200

Open Access Review

Psychotropics and Neuroprotection: Literature Review and Case Series Report

Received: 10 November 2019;  Published: 10 January 2020;  doi: 10.21926/obm.neurobiol.2001048

Abstract

Agitation is a common manifestation of acute brain injury. When not addressed, agitation can lead to slower recovery rates, including delayed admission to acute rehabilitation programs. Antipsychotics are commonly used to control agitation in acute brain injury in the ICU. However, there is no curre [...]

70 671

Open Access Original Research

Exploring Quality of Sleep, Perceived Stress and Resilience in Cancer Survivorship: A Feasibility Study of Mindfulness in Motion

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.neurobiol.1904047

Abstract

(1) Background: The global principles of Mindfulness-Based Stress Reduction (MBSR) have led to the creation of Mindfulness-Based Interventions (MBIs), which are interventions that retrain the mind to modify its usual stress response to increase coping and resilience. Mindfulness in Motion (MIM) is a [...]

81 1311

Open Access Review

Alzheimer’s Disease: Is a Dysfunctional Mevalonate Biosynthetic Pathway the Master-Inducer of Deleterious Changes in Cell Physiology?

Received: 03 October 2019;  Published: 29 November 2019;  doi: 10.21926/obm.neurobiol.1904046

Abstract

The awareness is growing that the proteins amyloid-beta (Aβ) and tau are rather a result of Alzheimer’s disease (AD) than its cause. Similarly, doubt reigns about the degree of causality of high plasma cholesterol/lipids (the fat connection) and of prenylation. An important conceptual addition to [...]

83 1044

Open Access Research Article

Relationship between Brain Injury and Clinical Biomarkers in Hypoxic-Ischemic Newborn Piglets

Received: 24 June 2019;  Published: 15 November 2019;  doi: 10.21926/obm.neurobiol.1904045

Abstract

(1) Background: Newborn affected by hypoxic-ischemic brain injury can die and the survivors suffer neurodevelopmental handicaps. Biomarkers are needed to identify the severity of hypoxic-ischemic insult in order to early determine the rescue treatment. The aim of this study was to correlate the path [...]

70 722

Open Access Research Article

The Relationship between Sleep Quality and Eating Competence in A Sample of Canadian Post-Secondary Students

Received: 09 August 2019;  Published: 31 October 2019;  doi: 10.21926/obm.neurobiol.1904044

Abstract

Background: Post-secondary students are at increased risk for sleep problems and poor eating behaviours that overtime may lead to negative health outcomes later in life. However, limited research has examined associations of sleep quality with eating behaviours and eating competence (e.g., being pos [...]

92 929

Open Access Original Research

Acute Exercise on Reversal Learning

Received: 15 July 2019;  Published: 09 October 2019;  doi: 10.21926/obm.neurobiol.1904043

Abstract

Objective: Reversal learning requires an individual to alter their behavior when previously learned reward-based contingencies are reversed. Reversal learning is heavily influenced by cognitive flexibility, which has been shown to be enhanced with acute exercise. However, minimal work has directly e [...]

99 945

Open Access Review

Transcranial Magnetic Stimulation: A Tool for Quantifying Neurophysiological Changes in the Brain Following Concussion Injury in Sports

Received: 05 July 2019;  Published: 27 September 2019;  doi: 10.21926/obm.neurobiol.1903042

Abstract

(1) Background: Sport-related concussion is a growing public health concern. Defined as a functional injury, concussion is characterised by a constellation of signs and symptoms. However, clinical imaging methods do not reveal any structural damage. Recently, neurophysiological techniques such as tr [...]

77 869

Open Access Research Article

The End Effector of Ischemic Tolerance Present in Blood Plasma from Double Conditioned Donors Ameliorates Trimethyltin Provoked Damage in Brain

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Abstract

Background: Hundreds of experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. The translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-methyltin poi [...]

103 859

Open Access Review

Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases

Received: 22 August 2019;  Published: 16 September 2019;  doi: 10.21926/obm.neurobiol.1903040

Abstract

Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

85 941

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