Table of Content

Open Access Research Article

Correlation of CT and MR Perfusion and Permeability Parameters for Intracranial Tumors

Kirsten Greenlaw, Jai Jai Shiva Shankar
Received: October 7, 2018; Published: January 14, 2019; doi:10.21926/obm.neurobiol.1901019

Abstract: Background and Purpose: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating [...]

86 462

Open Access Case Report

Cerebellopontine Angle Glioblastoma with Concurrent Spinal Cord Involvement: A Case Report and Review of Literature

Rahul Abhyankar, Divya Mella, Edward Pan
Received: November 12, 2018; Published: January 4, 2019; doi:10.21926/obm.neurobiol.1901018

Abstract: Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebelloponti [...]

60 623

Open Access Review

Sleep Disorders in Children with Central Nervous System Tumors

Melissa A. Maloney, Katherine E. Lewinter, Sally L. Davidson Ward, Iris A. Perez
Received: November 13, 2018; Published: December 17, 2018; doi:10.21926/obm.neurobiol.1804017

Abstract: Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hy [...]

75 524

Open Access Original Research

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Michele Bisceglia, Stefano Pizzolitto, Tullio Parracino, Giovanna De Maglio, Elena Minenna, Serena D’Agostini, Carlos A. Galliani
Received: October 7, 2018; Published: November 14, 2018; doi:10.21926/obm.neurobiol.1804016

Abstract: Thyroid transcription factor 1 (TTF-1) is a nuclear polypeptide, tissue-restricted member of the homeobox protein family, that when attached to DNA plays a crucial role in regulating the expression of select genes during early embryonic development of the thyroid, lung, and brain. As often happens, [...]

82 547

Open Access Review

Angiocentric Glioma: A Review of Clinicopathologic Features

Richard A. Prayson, MD, MEd
Received: September 4, 2018; Published: November 5, 2018; doi:10.21926/obm.neurobiol.1804015

Abstract: Along with focal cortical dysplasia, hippocampal sclerosis and remote infarcts, tumors are a well known cause of medically intractable or pharmacoresistent epilepsy [1-3]. Most of the tumors encountered in this setting represent low grade glioneuronal neoplasms, particularly gangliogliomas and dyse [...]

77 498

Open Access Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Divya B. Mella, Josie Sewell, Edward Pan
Received: October 12, 2018; Published: October 31, 2018; doi:10.21926/obm.neurobiol.1804014

Abstract: Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent us [...]

70 422

Open Access Research Article

Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival

Jai Jai Shiva Shankar, Adil Bata, Namita Sinha
Received: August 7, 2018; Published: October 26, 2018; doi:10.21926/obm.neurobiol.1804013

Abstract: Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to i [...]

69 383

Open Access Review

Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Concepts

Ruth Prieto, José M Pascual
Received: September 11, 2018; Published: October 16, 2018; doi:10.21926/obm.neurobiol.1804012

Abstract: Treatment of craniopharyngiomas (CPs) represents a neurosurgical challenge, the major reason being their close relationship with the hypothalamus and the third ventricle (3V) boundaries. Nevertheless, CPs are generally defined as “suprasellar” lesions, an imprecise and frequently faulty term. Despit [...]

55 490

Open Access Review

Contribution of PET Imaging to Clinical Management of Gliomas

Wolf-Dieter Heiss
Received: July 2, 2018; Published: September 20, 2018; doi:10.21926/obm.neurobiol.1803011

Abstract: Gliomas originating from glial cells, comprise about 30 % of all primary central nervous system tumors and 80 % of malignant brain tumors. Gliomas are different with respect to their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For [...]

50 484

Open Access Original Research

Haplo-Insufficiency or Knockout of the Serotonin Transporter Does not Affect Heroin Self-Administration but Decreases BDNF in the Frontal Cortex

Bridget W. Brox, Darren J. Day, Bart A. Ellenbroek
Received: February 1, 2018; Published: June 12, 2018; doi:10.21926/obm.neurobiol.1802010

Abstract: (1) Background: Drug addiction places a heavy burden on those affected by it but only a small percentage of individuals (~20%), regardless of their drug of abuse, go on to develop the compulsive behaviours that define drug addiction. Clinical studies have shown that genetic variations that reduce se [...]

57 543