Table of Content

Open Access Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Divya B. Mella, Josie Sewell, Edward Pan
Received: October 12, 2018; Published: October 31, 2018; doi:10.21926/obm.neurobiol.1804014

Abstract: Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent us [...]

55 316

Open Access Research Article

Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival

Jai Jai Shiva Shankar, Adil Bata, Namita Sinha
Received: August 7, 2018; Published: October 26, 2018; doi:10.21926/obm.neurobiol.1804013

Abstract: Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to i [...]

48 273

Open Access Review

Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Concepts

Ruth Prieto, José M Pascual
Received: September 11, 2018; Published: October 16, 2018; doi:10.21926/obm.neurobiol.1804012

Abstract: Treatment of craniopharyngiomas (CPs) represents a neurosurgical challenge, the major reason being their close relationship with the hypothalamus and the third ventricle (3V) boundaries. Nevertheless, CPs are generally defined as “suprasellar” lesions, an imprecise and frequently faulty term. Despit [...]

30 372

Open Access Review

Contribution of PET Imaging to Clinical Management of Gliomas

Wolf-Dieter Heiss
Received: July 2, 2018; Published: September 20, 2018; doi:10.21926/obm.neurobiol.1803011

Abstract: Gliomas originating from glial cells, comprise about 30 % of all primary central nervous system tumors and 80 % of malignant brain tumors. Gliomas are different with respect to their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For [...]

38 354

Open Access Original Research

Haplo-Insufficiency or Knockout of the Serotonin Transporter Does not Affect Heroin Self-Administration but Decreases BDNF in the Frontal Cortex

Bridget W. Brox, Darren J. Day, Bart A. Ellenbroek
Received: February 1, 2018; Published: June 12, 2018; doi:10.21926/obm.neurobiol.1802010

Abstract: (1) Background: Drug addiction places a heavy burden on those affected by it but only a small percentage of individuals (~20%), regardless of their drug of abuse, go on to develop the compulsive behaviours that define drug addiction. Clinical studies have shown that genetic variations that reduce se [...]

40 407

Open Access Review

Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction

Gina Sizemore, Brandon Lucke-Wold, Charles Rosen, James W. Simpkins, Sanjay Bhatia, Dandan Sun
Received: January 12, 2018; Published: June 1, 2018; doi:10.21926/obm.neurobiol.1802009

Abstract: The brain is an integrated network of multiple variables that when compromised creates a disease state. The neuropathology of temporal lobe epilepsy, stroke, and traumatic brain injury demonstrate both similarity and complexity that reflects this integrated variability; temporal lobe epilepsy with i [...]

52 499

Open Access Editorial

The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health

Bart A. Ellenbroek, Weiwen Wang
Received: March 20, 2018; Published: March 29, 2018; doi:10.21926/obm.neurobiol.1801008

Abstract: None

50 362

Open Access Editorial

Mitochondria, Brain, Heart and Body

Ya Wen
Received: November 28, 2017; Published: December 5, 2017; doi:10.21926/obm.neurobiol.1704007

Abstract: More and more studies revealed links amongst neurological disorders, heart diseases and cancers. For example, people with subclinical cardiovascular diseases are at higher risk for Alzheimer's disease, Parkinson’s disease is associated with varied risk of cancer, Autism Spectrum Disorders and cancer [...]

34 399

Open Access Review

Perspective on Neurobiological and Clinical Early Indicators of Mild Cognitive Decline and Alzheimer’s Disease

Jigar Jogia
Received: April 16, 2017; Published: July 10, 2017; doi:10.21926/obm.neurobiol.1702006

Abstract: There is a need for early diagnosis, monitoring and treatment of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Traditional assessments of cognitive decline have been found to lack sensitivity and accuracy in differentiating varying stages of Demetria and cognitive decline as well as [...]

40 343

Open Access Review

Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders

Mason L. Yeh , Eric S. Levine
Received: April 11, 2017; Published: April 27, 2017; doi:10.21926/obm.neurobiol.1702005

Abstract: Autism spectrum disorders (ASDs) are diagnosed on the basis of three behavioral features, namely, (1) deficits in social communication, (2) absence or delay in language and (3) stereotypy. The consensus regarding the neurological pathogenesis of ASDs is aberrant synaptogenesis and synapse function. [...]

30 407

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