Table of Content

Open Access Review

Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders

Mason L. Yeh , Eric S. Levine
Received: April 11, 2017; Published: April 27, 2017; doi:10.21926/obm.neurobiol.1702005

Abstract: Autism spectrum disorders (ASDs) are diagnosed on the basis of three behavioral features, namely, (1) deficits in social communication, (2) absence or delay in language and (3) stereotypy. The consensus regarding the neurological pathogenesis of ASDs is aberrant synaptogenesis and synapse function. [...]

30 424

Open Access Review

A Neurodevelopmental Perspective for Autism-Associated Gene Function

Jessie Poquérusse, Bryan W. Luikart
Received: April 10, 2017; Published: April 25, 2017; doi:10.21926/obm.neurobiol.1702004

Abstract: Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes will shed light onto the neurodevelopmental basis of ASD. Here, we defined functional categories repr [...]

40 400

Open Access Perspective

Neurobiology of Sleep and Microbiomics in Aging

Linda J. Larson-Prior, Gohar Azhar,David G. Davila,  Se-Ran Jun, Aaron S. Kemp, Intawat Nookaew, Jeanne Y. Wei, Trudy M. Wassenaar
Received: April 5, 2017; Published: April 12, 2017; doi:10.21926/obm.neurobiol.1702003

Abstract: (1) Background: The daily rhythms of life on earth are governed by a central clock located in the hypothalamus and entrained primarily by light. By virtue of its connections to a myriad of other clocks located both in the brain and in peripheral organs and cells, this clock provides a timing signal [...]

27 417

Open Access Opinion

FASD and Brain Development: Perspectives on Where We are and Where We Need to Go

Laurie C. Delatour, Hermes H. Yeh
Received: March 14, 2017; Published: March 23, 2017; doi:10.21926/obm.neurobiol.1701002

Abstract: Maternal consumption of alcohol (ethanol) during pregnancy can lead to life-long neurobehavioral and cognitive abnormalities in the offspring, collectively referred to as Fetal Alcohol Spectrum Disorders (FASD). Prenatal exposure to ethanol is one of the leading causes of non-genetic intellectual di [...]

26 488

Open Access Perspective

Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders

Jenny Berrío , Weiwen Wang, Bart A. Ellenbroek
Received: February 27, 2017; Published: March 15, 2017; doi:10.21926/obm.neurobiol.1701001

Abstract: Antipsychotics have been a pillar in the treatment of schizophrenia since their introduction more than 60 years ago. Their variety in structures and receptor binding properties confers on them a complex clinical profile of effectiveness and risk of adverse side-effects. Although antipsychotics are b [...]

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