Table of Content

Open Access Original Research

Haplo-Insufficiency or Knockout of the Serotonin Transporter Does not Affect Heroin Self-Administration but Decreases BDNF in the Frontal Cortex

Bridget W. Brox, Darren J. Day, Bart A. Ellenbroek
Received: February 1, 2018; Published: June 12, 2018; doi:10.21926/obm.neurobiol.1802010

Abstract: (1) Background: Drug addiction places a heavy burden on those affected by it but only a small percentage of individuals (~20%), regardless of their drug of abuse, go on to develop the compulsive behaviours that define drug addiction. Clinical studies have shown that genetic variations that reduce se [...]

64 603

Open Access Review

Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction

Gina Sizemore, Brandon Lucke-Wold, Charles Rosen, James W. Simpkins, Sanjay Bhatia, Dandan Sun
Received: January 12, 2018; Published: June 1, 2018; doi:10.21926/obm.neurobiol.1802009

Abstract: The brain is an integrated network of multiple variables that when compromised creates a disease state. The neuropathology of temporal lobe epilepsy, stroke, and traumatic brain injury demonstrate both similarity and complexity that reflects this integrated variability; temporal lobe epilepsy with i [...]

89 745

Open Access Editorial

The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health

Bart A. Ellenbroek, Weiwen Wang
Received: March 20, 2018; Published: March 29, 2018; doi:10.21926/obm.neurobiol.1801008

Abstract: None

77 590

Open Access Editorial

Mitochondria, Brain, Heart and Body

Ya Wen
Received: November 28, 2017; Published: December 5, 2017; doi:10.21926/obm.neurobiol.1704007

Abstract: More and more studies revealed links amongst neurological disorders, heart diseases and cancers. For example, people with subclinical cardiovascular diseases are at higher risk for Alzheimer's disease, Parkinson’s disease is associated with varied risk of cancer, Autism Spectrum Disorders and cancer [...]

62 599

Open Access Review

Perspective on Neurobiological and Clinical Early Indicators of Mild Cognitive Decline and Alzheimer’s Disease

Jigar Jogia
Received: April 16, 2017; Published: July 10, 2017; doi:10.21926/obm.neurobiol.1702006

Abstract: There is a need for early diagnosis, monitoring and treatment of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Traditional assessments of cognitive decline have been found to lack sensitivity and accuracy in differentiating varying stages of Demetria and cognitive decline as well as [...]

69 544

Open Access Review

Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders

Mason L. Yeh , Eric S. Levine
Received: April 11, 2017; Published: April 27, 2017; doi:10.21926/obm.neurobiol.1702005

Abstract: Autism spectrum disorders (ASDs) are diagnosed on the basis of three behavioral features, namely, (1) deficits in social communication, (2) absence or delay in language and (3) stereotypy. The consensus regarding the neurological pathogenesis of ASDs is aberrant synaptogenesis and synapse function. [...]

50 646

Open Access Review

A Neurodevelopmental Perspective for Autism-Associated Gene Function

Jessie Poquérusse, Bryan W. Luikart
Received: April 10, 2017; Published: April 25, 2017; doi:10.21926/obm.neurobiol.1702004

Abstract: Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes will shed light onto the neurodevelopmental basis of ASD. Here, we defined functional categories repr [...]

57 596

Open Access Perspective

Neurobiology of Sleep and Microbiomics in Aging

Linda J. Larson-Prior, Gohar Azhar,David G. Davila,  Se-Ran Jun, Aaron S. Kemp, Intawat Nookaew, Jeanne Y. Wei, Trudy M. Wassenaar
Received: April 5, 2017; Published: April 12, 2017; doi:10.21926/obm.neurobiol.1702003

Abstract: (1) Background: The daily rhythms of life on earth are governed by a central clock located in the hypothalamus and entrained primarily by light. By virtue of its connections to a myriad of other clocks located both in the brain and in peripheral organs and cells, this clock provides a timing signal [...]

44 625

Open Access Opinion

FASD and Brain Development: Perspectives on Where We are and Where We Need to Go

Laurie C. Delatour, Hermes H. Yeh
Received: March 14, 2017; Published: March 23, 2017; doi:10.21926/obm.neurobiol.1701002

Abstract: Maternal consumption of alcohol (ethanol) during pregnancy can lead to life-long neurobehavioral and cognitive abnormalities in the offspring, collectively referred to as Fetal Alcohol Spectrum Disorders (FASD). Prenatal exposure to ethanol is one of the leading causes of non-genetic intellectual di [...]

44 734

Open Access Perspective

Perspectives on the Neurobiology of Antipsychotic Drugs in Psychiatric Disorders

Jenny Berrío , Weiwen Wang, Bart A. Ellenbroek
Received: February 27, 2017; Published: March 15, 2017; doi:10.21926/obm.neurobiol.1701001

Abstract: Antipsychotics have been a pillar in the treatment of schizophrenia since their introduction more than 60 years ago. Their variety in structures and receptor binding properties confers on them a complex clinical profile of effectiveness and risk of adverse side-effects. Although antipsychotics are b [...]

52 685

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