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Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Abstract: Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for tra [...]

Open Access Original Research

Liver Transplantation or Resection for Treatment of Hepatocellular Carcinoma in Patients with Well-Compensated Cirrhosis: A Decision Analysis Model

Amanda B. Cooper, Stephen M. Downs, Nicholas J Skill, Richard S. Mangus, Chandrashekhar A. Kubal, Mary A. Maluccio
Received: March 18, 2019; Published: May 13, 2019; doi:10.21926/obm.transplant.1902063

Abstract: Hepatocellular carcinoma (HCC) is a lethal tumor, for which liver resection and transplantation are the only potentially curative treatments. No prospective, randomized study has compared survival in patients with compensated cirrhosis after the two operations. Decision analysis modeling is an objec [...]

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062

Abstract: Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe [...]

Open Access Review

Update in the Use of Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy After Heart Transplantation

Richard Cheng, Jon Kobashigawa
Received: January 23, 2019; Published: April 09, 2019; doi:10.21926/obm.transplant.1902061

Abstract: Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generat [...]

Open Access Review

Right Heart Failure in Left Ventricular Assist Device Patients

James Farag, Silvana Marasco
Received: February 13, 2019; Published: April 08, 2019; doi:10.21926/obm.transplant.1902060

Abstract: Left ventricular assist devices (LVADs) improve quality of life in end-stage heart failure patients but a frequent complication is Right heart failure (RHF) causing significant morbidity and mortality. This review article discusses key issues that need to be considered in the assessment and clinical [...]

Open Access Review

Islet Autotransplantations for Total Pancreatectomy

Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama  
Received: January 15, 2019; Published: April 03, 2019; doi:10.21926/obm.transplant.1902059

Abstract: Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease like chronic pancreatitis or pancreatic injury. However, it always abolishes the pancreatic exo- and endocrine functions and the nutritional condition of the patients is significantly impaired. [...]

Open Access Case Report

Secondary Antibody Deficiency in a Heart Recipient with Systemic Aspergillosis

Javier Carbone, Juan Fernandez-Yañez, Iago Sousa, Patricia Muñoz, Elizabeth Sarmiento
Received: November 23, 2018; Published: March 22, 2019; doi:10.21926/obm.transplant.1901058

Abstract: Secondary antibody deficiency has been associated with risk of invasive fungal infections in solid organ transplantation. Single center, multicenter and metanalysis studies have tested this association. Therapy of these infectious complications in the presence of a secondary antibody deficiency afte [...]

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