Table of Content

Open Access Case Report

Toxoplasmosis: “An Often Forgotten Cause for Fever of Unknown Origin in Liver Transplant Recipients”. Case Report and Review of Literature

Jose A. Morillas, Sherif Beniameen Mossad
Received: October 24, 2019; Published: November 18, 2019; doi:10.21926/obm.transplant.1904091

Abstract: Toxoplasmosis in liver transplantation (LT) is uncommon, especially in the current era of universal prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jirovecii pneumonia (PJP). Here we present a case of a 55-year-old woman LT recipient, on dapsone or PJP prophylaxis due to su [...]

58 526

Open Access Original Research

Combination, Sequential Therapies Incorporating Tocilizumab Decrease the Progression of Chronic Lung Allograft Dysfunction (CLAD) after Lung Transplantation: Initial Clinical Experience

David J. Ross, Abbas Ardehali, Christine Natori, John A. Belperio 
Received: September 19, 2019; Published: November 07, 2019; doi:10.21926/obm.transplant.1904090

Abstract: INTRODUCTION: TH-17 and IL-6 interactions and detrimental biologic effects have been shown in rodent models of Chronic Lung Allograft Dysfunction (CLAD). Similarly, these pathways have been found to be upregulated in human CLAD. Tocilizumab (TCZ), a humanized monoclonal antibody targets the IL-6 r [...]

60 547

Open Access Case Report

A Silent and Very Early Post-Liver Transplant Death by Candida Arteritis

Kyungmin Ko, Juan F. Guerra, David F. Garvin
Received: August 29, 2019; Published: October 28, 2019; doi:10.21926/obm.transplant.1904089

Abstract: Background: Graft site candidiasis is a serious complication after solid organ transplantation, often presenting as invasive arteritis leading to graft loss or even death. Case Report: We report a case of anastomotic site candidiasis leading to arterial rupture and death at postoperative day 10 with [...]

70 545

Open Access Original Research

Oral Management in Pre-HSCT Patients: An Evaluation of Oral and Systemic Complications

Renato Pol, Tiziana Ruggiero, Luisa Giaccone, Davide Camisassa, Andrea Spadafora, Giulia Rivetti, Marta Bezzi, Stefano Carossa
Received: June 14, 2019; Published: October 23, 2019; doi:10.21926/obm.transplant.1904088

Abstract: Objective Hematopoietic stem cell transplant has to be preceded by chemotherapy and radiotherapy. The following neutropenia and thrombocytopenia could be the cause of post transplant complications. Patient undergoing transplantation need to be eradicated of any possible infectious focus. Nowadays th [...]

103 582

Open Access Case Report

The Surgical Approach for Obtaining Abdominal Wall Closure in Renal Transplant Recipients with Temporary or Permanent Loss of Fascial Integrity Following Emergency Reoperative Surgery

Susanna Lam, Jerome M Laurence, Deborah J Verran
Received: July 01, 2019; Published: October 08, 2019; doi:10.21926/obm.transplant.1904087

Abstract: A range of corrective surgical procedures may be required in adult renal transplant recipients who sustain loss of integrity of the abdominal wall in the first month postoperatively. Where this involves the fascia, such as in acute fascial dehiscence or in renal allograft compartment syndrome, more [...]

78 662

Open Access Review

Present and Future Strategies with Curative Intent for Hereditary Hemoglobinopathies

Vanessa G. Oliveira, Filipa Saraiva, Fátima Costa, Aida Botelho de Sousa
Received: February 27, 2019; Published: September 23, 2019; doi:10.21926/obm.transplant.1903086

Abstract: Nowadays, hematopoietic stem cell transplantation (HSCT) is a common procedure in Hematology Units within Reference Centres, mainly for the treatment of hematological malignancies such as multiple myeloma, lymphoma and acute leukemia. Nevertheless, HSCT has much wider applications namely in autoimmu [...]

101 698

Open Access Review

Infectious Considerations for Patients on Immune Checkpoint Inhibitors

Anita Modi, Sherif Beniameen Mossad
Received: July 07, 2019; Published: September 06, 2019; doi:10.21926/obm.transplant.1903085

Abstract: Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of m [...]

78 696

Open Access Review

Benefits of Combined Liver Transplant: Protection or Tolerance?

Salim Hamdani, Daniel Azoulay
Received: April 18, 2019; Published: September 04, 2019; doi:10.21926/obm.transplant.1903084

Abstract: The privileged liver by its immunological status is described as a tolerogenic organ. However, these alone do not explain the installation of a tolerance after single or combined liver transplantation (kidney, heart, pancreas, intestine). Other factors appear to be involved in the identification of [...]

88 717

Open Access Research Article

Characterization of Early Indicators of Cardiac Allograft Vasculopathy Lesions in a Rat Model Using Non-Invasive Cellular MR

Qing Ye, Yijen L. Wu, Lesley M. Foley, Parker H. Mills, Fang-Cheng Yeh, Haosen Zhang, Danielle F. Eytan, Li Liu, T. Kevin Hitchens, Chien Ho
Received: January 07, 2019; Published: August 29, 2019; doi:10.21926/obm.transplant.1903083

Abstract: Background: Cardiac allograft vasculopathy (CAV) remains a major obstacle to long-term heart allograft survival. A number of studies show that immune mechanisms involved in CAV. Using non-invasive cellular MRI (CMRI) to explore indicators of CAV lesions and characterize its development could provi [...]

99 761

Open Access Short Report

Estradiol 17-β Induces Pancreatic Beta-Cell Proliferation through Distinct Estrogen Receptors in a Glucose Dependent Manner

Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Gaby Shefer, Dalia Somjen, Naftali Stern
Received: April 17, 2019; Published: August 27, 2019; doi:10.21926/obm.transplant.1903082

Abstract: Background: Estradiol 17-beta (E2) enhances the function and survival of pancreatic beta-cells but its clinical use has been questioned due to concerns regarding oncogenic potential and feminizing effects in males. The G-protein coupled estrogen receptor (GPER), expressed in pancreatic islets, exhib [...]

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