Table of Content

Open Access Review

Viral Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Literature Review

Shruthi Kodad, Waleed Sabry, Assem Elsayed, Hadi Goubran, Mohamed Elemary
Received: June 25, 2019; Published: August 26, 2019; doi:10.21926/obm.transplant.1903081

Abstract: Hematopoietic stem cell transplant (HSCT) recipients are at an increased risk of bacterial, viral, fungal and parasitic infections. Past exposures to infections, the degree of immunosuppression, prolonged neutropenia and presence of graft versus host disease (GVHD) are some of the factors which make [...]

85 781

Open Access Review

Induction of Tolerance towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models

Scott S. Graves, David W. Mathes, Rainer Storb
Received: November 23, 2018; Published: August 23, 2019; doi:10.21926/obm.transplant.1903080

Abstract: Background: The application of hematopoietic cell transplantation for induction of immune tolerance has been limited by toxicities associated with conditioning regimens and to graft-versus-host disease (GVHD). Decades of animal studies have culminated into sufficient control of these two problems, m [...]

91 757

Open Access Original Research

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

Elizabeth F. Wallin, Michelle A. Linterman, Kathryn J. Wood
Received: June 02, 2019; Published: August 19, 2019; doi:10.21926/obm.transplant.1903079

Abstract: Background - T follicular helper (Tfh) and regulatory (Tfr) cells are key players in the formation of long-lived antibody responses. Their circulating counterparts, cTfh and cTfr, are often used as biomarkers because longitudinal sampling of secondary lymphoid tissues is unfeasible in clinical studi [...]

77 811

Open Access Research Article

Immunoprotective Encapsulation of Micro-Organs

Assaf Assis, Lena Sapozhnikov, Sandra Camargo, Eduardo Mitrani
Received: May 07, 2019; Published: August 14, 2019; doi:10.21926/obm.transplant.1903078

Abstract: Background: Cell encapsulation technology is most likely the ultimate solution for autologous cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct, is to consider not only the nature of the capsule but also how the cells should be incorporated into [...]

79 812

Open Access Original Research

Mortality Risk Factors in Patients who are in Heart Transplantation Waiting List

Petr A. Fedotov, Maria A. Simonenko, Yulia V. Sazonova, Mariya A. Bortsova, Artem N. Kostomarov, Mariya Yu. Sitnikova
Received: February 01, 2019; Published: August 05, 2019; doi:10.21926/obm.transplant.1903077

Abstract: Purpose: to estimate the survival of patients in a heart transplantation waiting list (HTxWL) at V.A.Almazov NMRC from 2010 to 2017 and to define risk factors for death among these patients. Materials and methods: A single-centre retrospective study of 151 patients with advanced chronic heart failur [...]

65 759

Open Access Research Article

Never Say Never: Unexpected Pulmonary Pathogens Found on Autopsy in Hematopoietic Cell Transplantation Recipients

Ashrit Multani, Libby S. Allard, Joanna K. Nelson
Received: June 03, 2019; Published: July 29, 2019; doi:10.21926/obm.transplant.1903076

Abstract: Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a ser [...]

75 946

Open Access Review

Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Omer Eugene Beaird, Deepa Nanayakkara, Pryce Gaynor, Joanna Schaenman
Received: April 05, 2019; Published: July 26, 2019; doi:10.21926/obm.transplant.1903075

Abstract: The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for a dimorphic life cycle, a specific geographic distribution, and typical infection via environmental exposure. Their nonspecific presentation, often mimicking othe [...]

90 1010

Open Access Review

Our Steps toward Subcutaneous Transplantation of Macro-Encapsulated Islets

Shoichiro Sumi, Sin-Yu Yang, Priyadarshini Canning, Kai-Chiang Yang
Received: May 29, 2019; Published: July 24, 2019; doi:10.21926/obm.transplant.1903074

Abstract: Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, micro-encapsulated islets used in rec [...]

100 848

Open Access Review

Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Melissa Mortensen, Christine Lundberg, Simon Horslen
Received: December 05, 2018; Published: July 17, 2019; doi:10.21926/obm.transplant.1903073

Abstract: Background: Infants and children undergoing liver transplant require ongoing nutritional evaluation throughout the pre and post-transplant period. The pathophysiologic causes of chronic liver disease and acute liver failure are varied, and each present different and unique nutritional challenges. Me [...]

107 901

Open Access Review

Single Cell Transcriptomic Analysis of Pancreatic β Cell Development and Differentiation from Pluripotent Stem Cells

Chunhui Xie, Lillian Ye, Yeh-Chuin Poh, George Harb
Received: May 06, 2019; Published: July 17, 2019; doi:10.21926/obm.transplant.1903072

Abstract: Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represen [...]

85 952

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