Table of Content

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Ibrahim Fathi, Takehiro Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi, Akiko Inagaki, Makiko Kikkawa, Fumiko Ono, Hiroo Iwata, Yohichi Yasunami, Masafumi Goto
Received: March 27, 2019; Published: July 09, 2019; doi:10.21926/obm.transplant.1903071

Abstract: BACKGROUND. Current non-human primate diabetic models, namely those induced by total pancreatectomy or streptozotocin (STZ) injection, suffer from several disadvantages, including a long surgical procedure, the need for continual digestive enzyme replacement, and a delayed oral intake after total pa [...]

100 907

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Abstract: In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the on [...]

94 756

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active GLP-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Abstract: Background One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality  cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have [...]

104 1149

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Abstract: The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understand [...]

83 936

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

81 703

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

86 692

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

106 745

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Abstract: Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for tra [...]

82 1169

Open Access Original Research

Liver Transplantation or Resection for Treatment of Hepatocellular Carcinoma in Patients with Well-Compensated Cirrhosis: A Decision Analysis Model

Amanda B. Cooper, Stephen M. Downs, Nicholas J Skill, Richard S. Mangus, Chandrashekhar A. Kubal, Mary A. Maluccio
Received: March 18, 2019; Published: May 13, 2019; doi:10.21926/obm.transplant.1902063

Abstract: Hepatocellular carcinoma (HCC) is a lethal tumor, for which liver resection and transplantation are the only potentially curative treatments. No prospective, randomized study has compared survival in patients with compensated cirrhosis after the two operations. Decision analysis modeling is an objec [...]

78 696

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062

Abstract: Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe [...]

86 725

TOP