Table of Content

Open Access Review

Cell based Therapy in Transplantation

Yi-nan Guo, Michael Grzelak, Byoung Chol Oh
Received: October 10, 2018; Published: December 14, 2018; doi:10.21926/obm.transplant.1804031

Abstract: One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive ther [...]

85 610

Open Access Case Report

Severe Passenger Lymphocyte Syndrome and Acute Rejection in ABO Compatible but non-Identical Liver Transplant Recipient from Hepatitis C Viremic Donor

Silvia Martini, Ezio David, Francesco Tandoi, Dominic Dell Olio, Antonio Amoroso, Mauro Salizzoni, Giorgio Maria Saracco, Renato Romagnoli
Received: September 27, 2018; Published: December 04, 2018; doi:10.21926/obm.transplant.1804030

Abstract: We report a burdensome case of transplantation of a HCV-viremic liver graft into a HCV-viremic recipient with minor AB0 mismatch.

80 569

Open Access Research Article

The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunction

Michael Y. Shino, Ariss DerHovanessian, David M. Sayah, Rajan Saggar, Ying Ying Xue, Abbas Ardehali, Barry R. Stripp, David J. Ross, Joseph P. Lynch, Robert M. Elashoff, S. Samuel Weigt, John A. Belperio
Received: September 11, 2018; Published: November 30, 2018; doi:10.21926/obm.transplant.1804029

Abstract: The long term clinical significance of respiratory infections after lung transplantation remains uncertain. In this retrospective single-center cohort study of 441 lung transplant recipients, we formally evaluate the association between respiratory infection and chronic lung allograft dysfunction (C [...]

102 733

Open Access Research Article

Identifying Novel Biomarkers of Frailty in Cirrhosis: Results from an Unbiased Proteomics Search from the Functional Assessment in Liver Transplantation (FrAILT) Study

Laura A. Huppert, Marie Sinclair, Jennifer C. Lai
Received: November 08, 2018; Published: November 28, 2018; doi:10.21926/obm.transplant.1804028

Abstract: BACKGROUND: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestatio [...]

103 597

Open Access Review

Allogeneic Hematopoietic Cell Therapies to Induce Tolerance in Kidney Transplantation

Yujie Wen, Anita Y. Chhabra, Joseph R. Leventhal, Suzanne T. Ildstad
Received: October 29, 2018; Published: November 21, 2018; doi:10.21926/obm.transplant.1804027

Abstract: In this review, we summarized the latest results from the interventional clinical trials on inducing clinical tolerance in the recipients of human leukocyte antigen (HLA)-matched or mismatched living donor kidney transplantation via establishment of either transient or durable donor chimerism by hem [...]

103 575

Open Access Opinion

The Conundrum of High Body Mass Index in Kidney Transplant Patients

Maria Irene Bellini, Joseph Ayathamattam, Paul Elliot Herbert
Received: October 19, 2018; Published: November 19, 2018; doi:10.21926/obm.transplant.1804026

Abstract: Obesity is on the rise and the number of end stage renal disease patients who are obese parallel this trend. There is no universally accepted guideline for wait-listing end stage renal disease obese patients in order to reduce short-term complications and improve long-term survival of the kidney gra [...]

89 574

Open Access Review

The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Tolerance

Sylvaine You, Lucienne Chatenoud
Received: September 25, 2018; Published: November 09, 2018; doi:10.21926/obm.transplant.1804025

Abstract: Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in [...]

78 551

Open Access Review

Evolution of Enzyme Requirements for Human Islet Isolation

Robert C. McCarthy, Michael L. Green, Francis E. Dwulet
Received: September 24, 2018; Published: November 8, 2018; doi:10.21926/obm.transplant.1804024

Abstract: Islet transplantation is becoming an established treatment option for managing a subset of adult patients who have type 1 diabetes mellitus. The success of this procedure is dependent upon the recovery of a sufficient number of functional human islets from donor organs for subsequent transplant. Her [...]

102 1798

Open Access Review

Bacterial Infections after Liver Transplantation: Updates in Post-Surgical Infections, Vancomycin-Resistant Enterococcus, and Multi-Drug Resistant Enterobacteriaceae

Masayuki Nigo, Rodrigo Hasbun, Karen J Vigil
Received: March 29, 2018; Published: November 2, 2018; doi:10.21926/obm.transplant.1804023

Abstract: Liver transplantation is a life-saving procedure available worldwide. Despite advances in its surgical and immunosuppressive strategies, infectious complications carry significant morbidity and mortality. Bacterial infections are the most common infective etiologies, and the majority are seen during [...]

74 633

Open Access Original Research

Early Nutrition during Critical Illness in Pediatric Patients Post-Hematopoietic Cell Transplantation

Alicia M Teagarden, Emma M Tillman, Courtney M Rowan
Received: April 24, 2018; Published: October 29, 2018; doi:10.21926/obm.transplant.1804022

Abstract: Background: Hematopoietic cell transplant (HCT) patients are a high-risk population for poor nutrition and decreased survival. There is little data on how nutrition in pediatric HCT patients affects need for critical care interventions and outcomes. Methods: We hypothesized that patients who did not [...]

97 560