Table of Contents

Open Access

ISSN 2577-5790

OBM Genetics , Volume 3 , Issue 1 (2019)

Pages: 180

Published: October 2019

(This book is a printed edition that was published in OBM Genetics)

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Cover Story: COMBinatorial Oligo-nucleotide FISH (COMBO-FISH) in combination with immunostaining offers novel approaches to specifically label the native chromatin architecture by means of fluorescence super-resolution single molecule localization microscopy (SMLM). Unique, repetitively binding COMBO-FISH probes (e.g., for centromere 9, Alu consensus, L1 sequences etc.) in combination with specific antibodies (e.g., for heterochromatin, euchromatin, radiation damage foci, etc.) reveal characteristic patterns in cell nuclei as being measured by SMLM. View this paper.

Volume 3,Issue 1

Open Access Review

The Role of Mitochondria in Oocyte and Early Embryo Health

Kyunga Kim, Shlomit Kenigsberg, Andrea Jurisicova, Yaakov Bentov
Received: January 1, 2019; Published: March 29, 2019; doi:10.21926/obm.genet.1901070

Open Access Opinion

Clonal Heterogeneity in Non-Small Cell Lung Cancer and the Possible Role in Predicting Response to Treatment with Immune Checkpoint Inhibitors

Annapaola Mariniello, Silvia Novello
Received: November 15, 2018; Published: March 22, 2019; doi:10.21926/obm.genet.1901069

Open Access Review

FISH-Based Analysis of Mosaic Aneuploidy and Chromosome Instability for Investigating Molecular and Cellular Mechanisms of Disease

Svetlana G. Vorsanova, Yuri B. Yurov, Ilia V Soloviev, Alexei D Kolotii, Irina A Demidova, Viktor S Kravets, Oxana S Kurinnaia, Maria A Zelenova, Ivan Y. Iourov
Received: February 8, 2019; Published: March 20, 2019; doi:10.21926/obm.genet.1901068

Open Access Technical Note

Interphase Quantitative Fluorescence in Situ Hybridization (IQ-FISH)

Ivan Y. Iourov , Ilia V. Soloviev, Yuri B. Yurov, Svetlana G. Vorsanova
Received: February 2, 2019; Published: March 20,2019; doi:10.21926/obm.genet.1901067

Open Access Research Article

New DNA Extraction Method for the Detection of Pneumocystis in Lung Tissue Samples of Colonized Individuals

Susana Ruiz-Ruiz, Carolina A Ponce, Nicole Pesantes, Rebeca Bustamante, Gianna Gatti, Viviana San Martin, Mireya Gutierrez, Mariana Izquierdo, Sergio L Vargas, Fabien Magne, Vicente Pérez-Brocal
Received: January 30, 2019; Published: March 18, 2019; doi:10.21926/obm.genet.1901066

Open Access Research Article

New Tools in Cognitive Neurobiology: Biotin-Digoxigenin Detection of Overlapping Active Neuronal Populations by Two-Color c-fos Compartment Analysis of Temporal Activity by Fluorescent in situ Hybridization (catFISH)

Khalid Saidov, Anna Tiunova, Oksana Subach, Fedor Subach, Konstantin Anokhin
Received: October 12, 2018; Published: March 4, 2019; doi:10.21926/obm.genet.1901065

Open Access Research Article

COMBO-FISH: A Versatile Tool Beyond Standard FISH to Study Chromatin Organization by Fluorescence Light Microscopy

Jin-Ho Lee, Florence Laure Djikimi Tchetgna, Matthias Krufczik, Eberhard Schmitt, Christoph Cremer, Felix Bestvater, Michael Hausmann
Received: September 14, 2018; Published: February 19, 2019; doi:10.21926/obm.genet.1901064

Open Access Opinion

Interphase FISH: A Helpful Assay in Prenatal Cytogenetics Diagnosis

Elena Sala, Donatella Conconi, Francesca Crosti, Nicoletta Villa, Serena Redaelli, Gaia Roversi
Received: October 1, 2018; Published: January 29, 2019; doi:10.21926/obm.genet.1901063

Open Access Technical Note

Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements

Patrick Weber, Cathia Rausch, Annina Scholl, M. Cristina Cardoso
Received: July 22, 2018; Published: January 25, 2019; doi:10.21926/obm.genet.1901062

Open Access Short Report

The Usefulness of Preimplantation Genetic Testing for Chromosome Aneuploidy Informed by A Randomised Controlled Trial

Paul Scriven
Received: October 29, 2018; Published: January 23, 2019; doi:10.21926/obm.genet.1901061

Open Access Review

Genotyping Pneumocystis jirovecii: Impacting Our Understanding of Interhuman Transmission

Maud Gits-Muselli, Stéphane Bretagne, Alexandre Alanio
Received: December 4, 2018; Published: January 18, 2019; doi:10.21926/obm.genet.1901060

Open Access Editorial

A Healthy and Happy 2019

Joep Geraedts
Received: January 14, 2019; Published: January 17, 2019; doi:10.21926/obm.genet.1901059

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