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Open Access

ISSN 2577-5790

© 2020 by the authors; CC BY 4.0 licence

OBM Genetics , Volume 4 , Issue 1 (2020)

Pages: 38

Published: May 2020

(This book is a printed edition that was published in OBM Genetics)

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Cover Story: Knight in Splicing Armor: Alternative Splicing as a Neuroprotective Mechanism. By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. For the nervous system, alternative splicing not only increases the proteome diversity, but also affords neuron the ability to quickly adapt to stress. With the urgency for neurodegenerative disease intervention rising, alternative splicing process represents excellent targets to focus on. View this paper.

Volume 4,Issue 1

Open Access Case Report

Knight in Splicing Armor: Alternative Splicing as a Neuroprotective Mechanism

Received: 13 January 2020;  Published: 20 March 2020;  doi: 10.21926/obm.genet.2001106

Abstract

By adjusting gene expression in response to environmental changes, cells can optimize fitness as needed. Alternative splicing is one of the most important post-transcriptional regulation steps, broadly involved in diverse physiological and pathological conditions. Here, we present 5 cases of alternative splicing conferring increased neuroprotection through diverse mechanisms. These examples highlight the enormous power of alternative splicing in maintaining viability of neurons. From [...]

Open Access Editorial

Epigenetics of Obesity and Diabetes: Emerging Roles and Mechanisms of Non-coding RNAs

Received: 16 March 2020;  Published: 17 March 2020;  doi: 10.21926/obm.genet.2001105

Open Access Editorial

Plant Genetics and Gene Study

Received: 03 March 2020;  Published: 04 March 2020;  doi: 10.21926/obm.genet.2001104

Open Access Communication

Effective Delivery of Cancer Vaccines with Oxidatively Photo-Inactivated Transgenic Leishmania for Tumor Immunotherapy in Mouse Models

Received: 29 December 2019;  Published: 24 February 2020;  doi: 10.21926/obm.genet.2001103

Abstract

The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent [...]

Open Access Editorial

Another Productive Year

Received: 13 January 2020;  Published: 14 January 2020;  doi: 10.21926/obm.genet.2001102

Abstract

At the beginning of a new year it is always good to look both backwards and forwards and to highlight a few items that are relevant with respect to the long-term development of our journal. As everybody knows, the principle of open access publishing is that the authors pay fees (the article‐processing charges or APCs) to publish in the journal rather than that the readers pay subscription costs for the journal. Three years ago, OBM Genetics started as an open access journal publishing its first [...]
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