OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).
Advances in Mitochondrial Genome Research
Submission Deadline: September 15, 2020 (Open) Submit Now
Frederic J. Brenner, PhD
Professor, Department of Biology, Grove City College, 100 Campus Drive, Grove City, PA 16127, USA
Research Interests: General Ecology; wildlife and fishery management; wildlife genetics; wildlife diseases; forestry
About this topic
Mitochondria are organelles of eukaryotic cells and have their own genomes. Their genomes are collectively called the mitochondrial genome. The participation of and control by nuclear genes are essential for both mitochondrial structure and its activities. Further, nuclear genes play a dominant role in the genetic control of the whole organism. Mitochondrial DNA (mtDNA) can be used for molecular phylogenetic studies. The genes in the mitochondrial genome are closely related to the oxidative phosphorylation of mitochondria and are, therefore, related to the energy supply in the cell. In recent years, it has been found that some neuromuscular degenerative diseases, Parkinson's disease, Alzheimer's disease, mitochondrial encephalomyopathy, maternally inherited diabetes, and deafness are related to mitochondrial genes. Some studies have also pointed out that aging may be related to the accumulation of mtDNA damage. In addition, since the mitochondrial gene belongs to the maternal inheritance, the analysis of the prenatal mitochondrial genome of the mother is of great significance for the birth of healthy babies.
The human mitochondrial genome is a double-stranded circular DNA molecule, consisting of 16,569 nucleotides. mtDNA variants have been linked to various diseases and important biological processes, such as cancer, aging, etc. Mitochondrial research is on the rise across multiple fields in the medical sciences. Especially with the rise of high throughput sequencing, researchers now can examine the mitochondria genome in unprecedented detail. In this Special Issue, we will compile the articles that reflect the information on current research on mitochondrial genomes. We welcome original research reports, review articles, communications, perspectives, etc., in all areas pertinent to this topic.