OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
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Long Non-coding RNAs in Genetic Disease
Submission Deadline: May 31, 2020 (Open) Submit Now
Gratien Prefontaine, PhD
Associate Professor, Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada
E-mail: firstname.lastname@example.org; email@example.com
Research Interests: Molecular biology; biochemistry; epigenetics; DNA methylation; CRISPR-CAS9; ChIP seq
About This Topic
This special issue will broadly cover mammalian genetic diseases concerning long non-coding RNAs (lncRNAs). Upon sequencing whole-cell human RNA, non-coding RNAs were suspected to be transcriptional noise. Now it is well established that they play many roles to influence transcription of protein-coding mRNAs as well as other functions. The human genome encodes more 58,000 lncRNAs eclipsing the number of genes that encode proteins. This issue will highlight recent research discoveries where lncRNAs have significant consequences for genetic disease.
There are two classes of non-coding RNAs, small RNAs (<200 nucleotides) and lncRNAs (>200 nucleotides). The later can act as chromatin organizers, guides for epigenetic modification and mRNA degradation, inhibitors of translation, modulators of nuclear architecture, RNA decoys and miRNA quenchers in addition to others. This issue will focus on molecular mechanisms and pathways of lncRNAs relevant to genetic diseases.
Understanding lncRNA function is of utmost importance and will inform on the etiology of many diseases. It will provide insight into treatment and offer novel approaches to the treatment of disease susceptibility, diagnoses, prognosis, drug selection and efficacy of therapy consistent with the root of genetic disorders and diseases.