OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
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Advances in Pharmacogenetics
Submission Deadline: November 30, 2020 (Open) Submit Now
Ana M Peiró, MD, PhD
Professor, Neuropharmacology on Pain (NED), Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain; Pain Unit, Department of Health of Alicante‐General Hospital, Alicante, Spain; Clinical Pharmacology Unit, Department of Health of Alicante-General Hospital, Alicante, Spain
E-mail: firstname.lastname@example.org; email@example.com
Research Interests: Pharmacogenetics; chronic pain; genes; pain treatment; epigenetics; genetic biomarker; genetic variability; pain management
About This Topic
Pharmacogenetics is a marginal subject combining pharmacology and genetics. It studies the influence of genetic factors on drug metabolism, especially the abnormal drug response caused by genetic factors. The study of pharmacogenetics has enriched the content of human genetics and has great significance in clinical medicine.
In pharmacogenetics, the influence of genetic factors on pharmacokinetics, especially in the role of abnormal drug reactions, is studied. Clinicians must follow the principles of different medicines when using them. As well-known, in a population, different individuals may have different reactions to a certain drug and may even have serious adverse side effects; this phenomenon is called individual idiosyncrasy. The cause of atopy depends, in a large part, on the genetic background of an individual.
Drugs must be absorbed, distributed, metabolized, and excreted in the body to complete the process of drug effects. In this process, many links are closely related to the role of enzymes and receptors. If there are mutations or defects in the genes that determine the enzymes or receptor proteins involved in drug metabolism, abnormal reactions become inevitable during the process. Therefore, it is necessary to understand the influence of genetic variations on drug response and its molecular basis, and predict the individuals who will respond to drug abnormalities accordingly, so that effective prevention and treatment can be planned in advance. The research on pharmacogenetics has revealed the genetic basis and biochemical nature of many abnormal drug reactions, which has guiding value for clinicians to correctly grasp the individualized principles of medication and prevent various genetic-related drug reactions.
In this special issue, we aim to compile the latest research results in pharmacogenetics. We will accept original research papers, reviews, editorial, short communications, case reports, perspectives, etc. on pharmacogenetics. We cordially welcome authors to contribute their excellent works to this exciting forum.