OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8 days from acceptance to publication (median values for papers published in this journal in 2020, 1-2 days of FREE language polishing time is also included in this period).
Advanced Dementia: Enjoy It or Avoid It?
Submission Deadline: November 15, 2020 (Open) Submit Now
Ladislav Volicer, MD, PhD
Courtesy Full Professor, School of Aging Studies, College of Arts and Sciences, University of South Florida, Tampa, FL, 33620, USA;
External Professor, 3rd Medical Faculty, Charles University, Prague, Czech Republic
Research Interests: Dementia; Alzheimer's disease; palliative care; medical ethics; behavioral symptoms of dementia
About This Topic
With the skyrocketing prevalence of age-related dementias and lack or curative treatment for Alzheimer’s disease and other progressive degenerative dementias, many persons will live with advanced dementia. In this condition, persons are dependent in all activities of daily living, cannot eat and drink, and ambulate independently and communicate verbally. Despite these disabilities, they can still enjoy life if pain, depression and behavioral symptoms of dementia are effectively treated, and meaningful activities designed for this population are provided. However, some persons are so afraid of living with advanced dementia that they want to avoid it at any cost. Some strategies for decreasing risk of dementia development exist but none of them assure that dementia will be prevented. Similarly, advance directives limiting life-sustaining medical intervention do not always prevent living with advance dementia, because the persons may not require them. Some persons commit suicide when they still can, and others include withdrawal of help with eating and drinking in their advance directives. Advance dementia challenge health care system and all of us to decide how to deal with this condition. Should we support enjoyment of life, avoidance of advance dementia or combination of both?
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