OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
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Dysphagia in the Elderly
Submission Deadline: January 15, 2020 (Open) Submit Now
David G Smithard, BSc MB MD FRCP FRCSLT(Hon)
Consultant in Elderly and Stroke Medicine, Geriatric Medicine, Queen Elizabeth Hospital, Lewisham and Greenwich NHS Trust, Woolwich, SE18 4QH, UK;
Research Fellow, Department of Sports Science, University of Greenwich, London, SE9 2UG, UK
Research Interests: Dysphagia; frailty; care homes; stroke; swallowing rehabilitation; healthy aging
About This Topic
Swallowing problems or oral pharyngeal dysphagia (OD) has many aetiological factors, is associated with a poor prognosis and eventually death. OD is recognised by many to be a new “Geriatric Giant”. Many countries are experiencing an ageing population, which inevitably means an increase in the number of people with long-term conditions (including frailty). OD will occur in the context of many long-term conditions, not just neurological disease, and is common in the presence of frailty. The frequency of OD in some medical conditions may reach 100% as the disease severity progresses.
There are many questions to be asked, including the question “what is normal” in the older generations particularly the very old. Without understanding this many people will be “medicalised” and investigated inappropriately.
This Special Edition is inviting papers on all subjects (e.g. pathophysiology, prevalence, management, rehabilitation) to do with swallowing and OD in older people, both reviews and novel research.
David Smithard, Signe Westmark, Dorte Melgaard
Received: September 15, 2019; Published: November 15 , 2019; doi:10.21926/obm.geriatr.1904086