Welcome to the new academic journal OBM Hepatology and Gastroenterology. Recent progress in understanding liver, biliary, pancreatic and gastro-intestinal diseases and their treatments has been observed in the world. OBM Hepatology and Gastroenterology publishes interesting and informative reviews, original articles, and invaluable case reports in this area. We also publish basic research as well as clinical research.

Hepatitis A virus (HAV), HBV, HCV, HDV, and HEV are still a serious issue worldwide. Treatments on these viruses have recently improved. However, liver fibrosis, cirrhosis and hepatocellular carcinoma are still critical conditions. We focus on all of these liver diseases. We also focus on broad-spectrum of gastro-intestinal diseases in this journal.

Please accept our special thanks for choosing to publish in the OBM Hepatology and Gastroenterology. We are looking forward to your submissions for OBM Hepatology and Gastroenterology.

Free Publication in 2019

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Richell Booijink, Ruchi Bansal
Received: March 27, 2019; Published: June 21, 2019; doi:10.21926/obm.hg.1902024

Abstract: Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of [...]

Open Access Review

Zinc in Liver Fibrosis

Kurt Grüngreiff , Thomas Gottstein, Dirk Reinhold
Received: March 15, 2019; Published: June 13, 2019; doi:10.21926/obm.hg.1902023

Abstract: Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connect [...]

Open Access Review

Managing Acute Severe Necrotising Pancreatitis

Michal Kawka, Tamara MH Gall, Long R Jiao
Received: February 25, 2019; Published: June 05, 2019; doi:10.21926/obm.hg.1902022

Abstract: Background: Severe necrotising pancreatitis (SNP) is characterised by high mortality, severe complications and bad prognosis despite progress in understanding of aetiology and progression of the disease. Traditionally, necrotic changes were removed by open necrosectomy but the paradigm has shifted t [...]

Open Access Opinion

The Curing of Crohn’s Disease

Gilles R. G. Monif
Received: January 06, 2019; Published: June 04, 2019; doi:10.21926/obm.hg.1902021

Abstract: Using the therapeutic intervention points identified by the Hruska Postulate, the probability of curing Crohn’s disease through destroying the anti-MAP template is discussed.

Open Access Research Article

NF-κB; the Critical Link between Immune and Metabolic Pathways: Could NF-κB be Used as a Novel Diagnostic and Prognostic Biomarker for Non-Alcoholic Steatohepatitis?

Athina Chasapi , Konstantinos Balampanis, Anna Tanoglidi, Eleni Kourea, George I. Lambrou, Vaia Lambadiari, Fotios Kalfarentzos, Erifili Hatziagelaki, Maria Melachrinou, Georgia Sotiropoulou-Bonikou
Received: January 28, 2019; Published: May 22, 2019; doi:10.21926/obm.hg.1902020

Abstract: (1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or [...]

Open Access Review

Organotin Polymers for the Control of Pancreatic Cancer

Charles E. Carraher, Jr., Michael R. Roner, Jessica Frank, Paul Slawek, Francesca Mosca, Kimberly Shahi, Alisa Moric-Johnson, Lindsey Miller
Received: January 31, 2019; Published: May 14, 2019; doi:10.21926/obm.hg.1902019

Abstract: Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epit [...]

Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Masaaki Takamura, Shuji Terai
Received: February 4, 2019; Published: April 25, 2019; doi:10.21926/obm.hg.1902018

Abstract: In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body flu [...]

Open Access Review

Walled-Off Necrosis in Acute Pancreatitis: Clinical and Therapeutic Implications

Raffaele Pezzilli
Received: February 07, 2019; Published: April 10, 2019; doi:10.21926/obm.hg.1902017

Abstract: Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic n [...]

Open Access Research Article

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Yumiko Nagao , Shinji Nishioka , Keizo Koresawa
Received: January 12, 2019; Published: April 2, 2019; doi:10.21926/obm.hg.1902016

Abstract: Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP), an extrahepatic manifestation, is well known. There are still patients with viral liver disease in this country who are not receiving appropriate treatment. This prospective study aimed to evaluate th [...]

Open Access Review

Endoscopic Management of Crohn’s Disease Strictures

Oliver Reed, Patrick B Allen, Grant Caddy, John Eccles, Tony CK Tham
Received: January 28, 2019; Published: March 26, 2019; doi:10.21926/obm.hg.1901015

Abstract: Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract which can result in luminal stenosis and up to 90% of patients requiring surgery during their lifetime. Medical management aims to reduce the inflammatory burden to prevent the development of inflammatory strictures, p [...]

Open Access Review

New Insights to Prevent Liver Fibrosis by Targeting YB-1 and Collagen Genes

Ramareddy V Guntaka
Received: December 20, 2018; Published: March 13, 2019; doi:10.21926/obm.hg.1901014

Abstract: Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such [...]

Open Access Review

Stem Cell Therapy in the Elderly with Liver Disease

Marcel Tomaszewski, Philip Wong
Received: August 23, 2018 ; Published: January 03, 2019; doi:10.21926/obm.hg.1901013

Abstract: There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has a significant negative effect upon quality of life and functi [...]

Open Access Original Research

Association between Liver Stiffness and Gastro-Esophageal Varices in Chronic Liver Diseases

Hirotaka Yamamoto, Maiko Kishino, Shinichi Nakamura, Etsuko Hashimoto, Katsutoshi Tokushige
Received: November 12, 2018 ; Published: December 27, 2018; doi:10.21926/obm.hg.1804012

Abstract: Objective: Elastography is a non-invasive examination method that can estimate the extent of liver fibrosis, measured as liver stiffness (LS). We examined the relationship between gastro-esophageal varices and the LS and how to predict esophageal varices and varices bleeding by LS. Methods: From 201 [...]

Open Access Original Research

Taste Impairment and Compliance Improvement of Branched-Chain Amino Acids in Patients with Liver Cirrhosis

Atsushi Naganuma, Satoru Kakizaki, Takashi Hoshino, Toshiyuki Tanaka, Tetsushi Ogawa, Tomoki Araki, Shuya Sawada, Satomi Adachi, Yusuke Ogawa, Toyoshi Sasaki, Ken Sato, Hitoshi Takagi, Toshio Uraoka
Received: September 26, 2018; Published: December 26, 2018; doi:10.21926/obm.hg.1804011

Abstract: Background: Branched-chain amino acids (BCAA) are nutrients with a bitter taste, which causes low compliance in patients who need BCAA supplementation. Moreover, chronic liver disease is frequently complicated by taste impairment. The present study was designed to improve patient noncompliance regar [...]

Open Access Communication

Gut Microbes and Pathophysiology of Sepsis: Spillage of Gut Microbial Products, rather than Systemic Dissemination of Gut Microbes, is the Potential Initiator of Septic Morbidity

Amale Laouar
Received: July 22, 2018; Published: September 10, 2018; doi:10.21926/obm.hg.1803010

Abstract: Gut microbes and pathophysiology of sepsis: Spillage of gut microbial products, rather than systemic dissemination of gut microbes, is the potential initiator of septic morbidity

Open Access Case Report

An Unusual Case of Signet Ring Cell Cholangiocarcinoma: Case Report and a Review of Literature

Shechter Yonat, Dagan Amir, BenHaim Menahem, Bar-Ziv Yaakov, Brazovsky Eliyau, Shteingart Shimon, Dancour Alian, Paz Kalman, Lurie Yoav
Received: February 17, 2018; Published: September 3, 2018; doi:10.21926/obm.hg.1803009

Abstract: Cholangiocarcinoma is an uncommon adenocarcinoma with poor prognosis. Signet ring cell cholangiocarcinoma is an extremely rare disease, with only 11 cases reported to date. However, its incidence is increasing. Similarly, there is an increasing incidence of other SRC tumors (colon, gastric etc.) as [...]

Open Access Original Research

Peptides Obtained by Enzymatic Decomposition of Mackerel Prevent Nonalcoholic Steatohepatitis in Sprague-Dawley Rats fed a High-fat and High-cholesterol Diet

Katsuhisa Omagari, Ayumi Fukuda, Machiko Suga, Ayumi Ogata, Shinta Nishioka, Kazuhito Suruga, Mayuko Ichimura, Koichi Tsuneyama
Received: April 9, 2018; Published: August 4, 2018; doi:10.21926/obm.hg.1803008

Abstract: Background: The pathogenesis of nonalcoholic steatohepatitis (NASH) is thought to be multifactorial, and oxidative stress may play an important role in the development of NASH. Peptides obtained by enzymatic decomposition of mackerel (EMP) including selenoneine were recently reported to possess anti [...]

Open Access Review

Models for Predicting Risk of Acute Kidney Injury after Liver Surgery

Habibur P. Rahman, Ricky H Bhogal, Patricia F. Lalor
Received: February 5, 2018; Published: May 16, 2018; doi:10.21926/obm.hg.1802007

Abstract: Background & Aims. Acute kidney injury (AKI) is a serious complication of liver surgery and associated with significant morbidity and mortality. The incidence of AKI following hepatic surgery can be as high as 94%, with highest rates seen following orthotopic liver transplantation, particularly when [...]

Open Access Original Research

Misinterpretation or Underestimation of the Appearance, Location, or Size of Non-bleeding Visible Vessels (Forrest Class IIa) as a Cause of Hemostasis Failure

Hidehiro Kamezaki, Dai Sakamoto, Daiki Okamura, Koji Nakagawa, Naoya Kato
Received: December 10, 2017; Published: March 15, 2018; doi:10.21926/obm.hg.1801006

Abstract: (1) Background: Endoscopy has become the primary diagnostic and treatment technique for non-variceal upper gastrointestinal bleeding. Despite advancements in therapeutic methods and instrumentation, endoscopic hemostatic failure occurs in 10% of patients. This study aimed to analyze endoscopic findi [...]

Open Access Editorial

Anemia during Direct-Acting Antiviral Regimens in Kidney Transplant Recipients with Hepatitis C

Tatsuo Kanda, Shunich Matsuoka, Mitsuhiko Moriyama
Received: October 18, 2017; Published: October 30, 2017; doi:10.21926/obm.hg.1704005

Abstract: (This is review and no abstract)

Open Access Case Report

Successful Treatment of a Pregnant Woman with Chronic Active Hepatitis B using Tenofovir Disoproxil Fumarate

Koji Takahashi, Tatsuo Kanda, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Shingo Nakamoto, Shin Yasui, Hidehiro Kamezaki, Osamu Yokosuka
Received: July 25, 2017; Published: July 28, 2017; doi:10.21926/obm.hg.1703004

Abstract: (1) Background: Infection with hepatitis B virus (HBV) infection during pregnancy occasionally raises concerns, including acute exacerbation and the potential for mother-to-child transmission. (2) Case Report: Here, we present a case of a female patient with a chronic HBV infection who was treated w [...]

Open Access Original Research

IFN-Based and IFN-Free Direct-Acting Antiviral Drug Treatments for Acquired Hepatitis C Virus in Post-Transplant Recipients

Tomomi Kogiso, Mutsuki Kobayashi, Kuniko Yamamoto, Yuichi Ikarashi, Kazuhisa Kodama, Makiko Taniai, Nobuyuki Torii, Kazunari Tanabe, Hideki Ishida, Shohei Fuchinoue, Hiroto Egawa, Masakazu Yamamoto, Etsuko Hashimoto, Katsutoshi Tokushige
Received: February 8, 2017; Published: April 6, 2017; doi:10.21926/obm.hg.1702003

Abstract: Background: Hepatitis C virus (HCV) infection frequently occurs in recipients of liver or kidney transplants (LT/KT). Interferon (IFN)-based therapies are used to treat HCV, but their efficacy is low. Methods: We report 24 patients who received HCV therapy after LT/KT. Design, Setting, and Particip [...]

Open Access Editorial

Response-Guided Treatment with an Ultrarapid Virological Response Creates the Future of Interferon-Free Treatment against Hepatitis C

Tatsuo Kanda, Osamu Yokosuka
Received: January 22, 2017; Published: February 4, 2017; doi:10.21926/obm.hg.1701002

Abstract: N/A

Open Access Case Report

Pneumocystis jirovecii pneumonia Suspected Due to Low-Dosage Prednisolone Treatment for Acute Autoimmune Hepatitis: Case Report and Literature Review

Hidehiro Kamezaki, Tatsuo Kanda, Osamu Yokosuka, Masanori Tsukahara, Yasunori Kasahara, Takayuki Sakurai
Received: October 11, 2016; Published: January 21, 2017; doi:10.21926/obm.hg.1701001

Abstract: (1) Background: Preventative treatment for Pneumocystis jirovecii pneumonia (PCP) has been recommended for patients receiving ≥20 mg/day prednisolone. We describe a patient who developed PCP while receiving a dose of 15 mg/day prednisolone, and consider criteria for the initiation of preventative th [...]

OBM Hepatology and Gastroenterology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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