Welcome to the new academic journal OBM Hepatology and Gastroenterology. Recent progress in understanding liver, biliary, pancreatic and gastro-intestinal diseases and their treatments has been observed in the world. OBM Hepatology and Gastroenterology publishes interesting and informative reviews, original articles, and invaluable case reports in this area. We also publish basic research as well as clinical research.

Hepatitis A virus (HAV), HBV, HCV, HDV, and HEV are still a serious issue worldwide. Treatments on these viruses have recently improved. However, liver fibrosis, cirrhosis and hepatocellular carcinoma are still critical conditions. We focus on all of these liver diseases. We also focus on broad-spectrum of gastro-intestinal diseases in this journal.

Please accept our special thanks for choosing to publish in the OBM Hepatology and Gastroenterology. We are looking forward to your submissions for OBM Hepatology and Gastroenterology.

Free Publication in 2019

Open Access Case Report

Partial Response of Alopecia Areata to Helicobacter Pylori Eradication and Treatment with Low-Dose Naltrexone

Laura Alonso Canal, María José Quiles Blanco, David Jiménez Leiva, María José González Iglesias
Received: June 26, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903037

Abstract: Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The i [...]

Open Access Perspective

Missing the Target to Treat in Crohn’s Disease

Herbert Van Kruiningen
Received: April 05, 2019; Published: September 30, 2019; doi:10.21926/obm.hg.1903036

Open Access Case Report

Secondary Acute Pancreatitis Associated with Paracetamol and Codeine Administration after Dental Treatment: Literature Analysis and Clinical Case Study

Alessandro Luigi Rossi, Vincenzo Capilupi, David Palombo, Luigi Tagliatesta, Tecla Terenzio, Marco Vitali, Matteo Chiapasco
Received: April 29, 2019; Published: August 30, 2019; doi:10.21926/obm.hg.1903035

Abstract: OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS A [...]

Open Access Review

Rare Causes of Acute Pancreatitis: Drugs, Eosinophilia, and Autoimmunity

Mauro Turrin
Received: March 15, 2019; Published: August 29, 2019; doi:10.21926/obm.hg.1903034

Abstract: Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February [...]

Open Access Review

Advanced Endoscopic Techniques in the Evaluation and Treatment of Fibrostenotic Crohn's Disease

Alina Wong, Scott D Lee
Received: May 09, 2019; Published: August 16, 2019; doi:10.21926/obm.hg.1903033

Abstract: Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring [...]

Open Access Review

Conventional and Future Therapies for Crohn's Disease

Abdulmaleek Sado, Rahul Kalla, Simon Campbell
Received: May 20, 2019; Published: August 14, 2019; doi:10.21926/obm.hg.1903032

Abstract: Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications [...]

Open Access Review

New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Rachel Rutherford, Patrick B Allen
Received: February 25, 2019; Published: August 12, 2019; doi:10.21926/obm.hg.1903031

Abstract: Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting [...]

Open Access Review

Pathological Angiogenesis: The New Culprit behind Chronic Liver Disease

Marta Ramirez, Mercedes Fernandez
Received: February 25, 2019; Published: July 31, 2019; doi:10.21926/obm.hg.1903030

Abstract: This review describes our current understanding of the pathogenic role of angiogenesis in chronic liver disease and portal hypertension, emphasizing its involvement not only in the liver but also in extrahepatic complications such as the formation of portosystemic collaterals and increased splanchni [...]

Open Access Review

Pancreatitis in Solid Organ Transplant Patients: A Review of the Literature

Danielle Graham, Takahiro Ito, Ronald Busuttil, Fady Kaldas
Received: May 05, 2019; Published: July 29, 2019; doi:10.21926/obm.hg.1903029

Abstract: Acute pancreatitis is a highly morbid condition widely recognized and well-defined in the general population. In this article, we summarize the current literature on acute pancreatitis in the setting of solid organ transplant axiom, including patients who are listed for or have undergone transplanta [...]

Open Access Review

Hereditary Pancreatitis – A Review of Current Concepts and Management

Daniel Hughes, Alex Gordon-Weeks, Michael A Silva
Received: April 30, 2019; Published: July 19, 2019; doi:10.21926/obm.hg.1903028

Abstract: (1) Background: Hereditary Pancreatitis is a rare cause of acute pancreatitis. These patients usually present at a young age with recurrent episodes of acute pancreatitis that usually progresses to chronic pancreatitis with associated endocrine and exocrine failure. Hereditary pancreatitis also ca [...]

Open Access Review

Therapeutic Strategies and Current Management for Hepatic Encephalopathy in Liver Cirrhosis

Kazuyuki Suzuki, Akinobu Kato, Yasuhiro Takikawa
Received: February 04, 2019; Published: July 16, 2019; doi:10.21926/obm.hg.1903027

Abstract: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minim [...]

Open Access Review

Review of Current Evidence in Acute Pancreatitis

Samantha Varley, Kirsten Rossi, Meghan Murray, Alissa Nichole
Received: May 17, 2019; Published: July 12, 2019; doi:10.21926/obm.hg.1903026

Abstract: Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stone [...]

Open Access Review

Nonalcoholic Fatty Liver Disease and Inflammatory Bowel Disease: Complex Interactions, Evaluations, and Management Decisions

Brett Sadowski, Sarah Ordway, Kevin Bobeck, Adam Tritsch, Manish Singla
Received: January 31, 2019; Published: June 28, 2019; doi:10.21926/obm.hg.1902025

Abstract: Diseases of the liver are commonly encountered in patients with Inflammatory Bowel Disease (IBD). While the differential for IBD patients with elevated liver associated enzymes is broad, it is similar to that of the general population. This differential includes including non-alcoholic fatty liver d [...]

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Richell Booijink, Ruchi Bansal
Received: March 27, 2019; Published: June 21, 2019; doi:10.21926/obm.hg.1902024

Abstract: Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of [...]

Open Access Review

Zinc in Liver Fibrosis

Kurt Grüngreiff , Thomas Gottstein, Dirk Reinhold
Received: March 15, 2019; Published: June 13, 2019; doi:10.21926/obm.hg.1902023

Abstract: Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connect [...]

Open Access Review

Managing Acute Severe Necrotising Pancreatitis

Michal Kawka, Tamara MH Gall, Long R Jiao
Received: February 25, 2019; Published: June 05, 2019; doi:10.21926/obm.hg.1902022

Abstract: Background: Severe necrotising pancreatitis (SNP) is characterised by high mortality, severe complications and bad prognosis despite progress in understanding of aetiology and progression of the disease. Traditionally, necrotic changes were removed by open necrosectomy but the paradigm has shifted t [...]

Open Access Opinion

The Curing of Crohn’s Disease

Gilles R. G. Monif
Received: January 06, 2019; Published: June 04, 2019; doi:10.21926/obm.hg.1902021

Abstract: Using the therapeutic intervention points identified by the Hruska Postulate, the probability of curing Crohn’s disease through destroying the anti-MAP template is discussed.

Open Access Research Article

NF-κB; the Critical Link between Immune and Metabolic Pathways: Could NF-κB be Used as a Novel Diagnostic and Prognostic Biomarker for Non-Alcoholic Steatohepatitis?

Athina Chasapi , Konstantinos Balampanis, Anna Tanoglidi, Eleni Kourea, George I. Lambrou, Vaia Lambadiari, Fotios Kalfarentzos, Erifili Hatziagelaki, Maria Melachrinou, Georgia Sotiropoulou-Bonikou
Received: January 28, 2019; Published: May 22, 2019; doi:10.21926/obm.hg.1902020

Abstract: (1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or [...]

Open Access Review

Organotin Polymers for the Control of Pancreatic Cancer

Charles E. Carraher, Jr., Michael R. Roner, Jessica Frank, Paul Slawek, Francesca Mosca, Kimberly Shahi, Alisa Moric-Johnson, Lindsey Miller
Received: January 31, 2019; Published: May 14, 2019; doi:10.21926/obm.hg.1902019

Abstract: Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epit [...]

Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Masaaki Takamura, Shuji Terai
Received: February 4, 2019; Published: April 25, 2019; doi:10.21926/obm.hg.1902018

Abstract: In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body flu [...]

Open Access Review

Walled-Off Necrosis in Acute Pancreatitis: Clinical and Therapeutic Implications

Raffaele Pezzilli
Received: February 07, 2019; Published: April 10, 2019; doi:10.21926/obm.hg.1902017

Abstract: Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic n [...]

Open Access Research Article

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Yumiko Nagao , Shinji Nishioka , Keizo Koresawa
Received: January 12, 2019; Published: April 2, 2019; doi:10.21926/obm.hg.1902016

Abstract: Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP), an extrahepatic manifestation, is well known. There are still patients with viral liver disease in this country who are not receiving appropriate treatment. This prospective study aimed to evaluate th [...]

Open Access Review

Endoscopic Management of Crohn’s Disease Strictures

Oliver Reed, Patrick B Allen, Grant Caddy, John Eccles, Tony CK Tham
Received: January 28, 2019; Published: March 26, 2019; doi:10.21926/obm.hg.1901015

Abstract: Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract which can result in luminal stenosis and up to 90% of patients requiring surgery during their lifetime. Medical management aims to reduce the inflammatory burden to prevent the development of inflammatory strictures, p [...]

Open Access Review

New Insights to Prevent Liver Fibrosis by Targeting YB-1 and Collagen Genes

Ramareddy V Guntaka
Received: December 20, 2018; Published: March 13, 2019; doi:10.21926/obm.hg.1901014

Abstract: Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such [...]

Open Access Review

Stem Cell Therapy in the Elderly with Liver Disease

Marcel Tomaszewski, Philip Wong
Received: August 23, 2018 ; Published: January 03, 2019; doi:10.21926/obm.hg.1901013

Abstract: There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has a significant negative effect upon quality of life and functi [...]

OBM Hepatology and Gastroenterology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.