OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Free Publication in 2019
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Open Access Editorial
Editorial: “A New Era in Neuro-Oncology”

Antonio Meola 

Stanford University Hospital and Clinics, Stanford, CA, USA

Correspondence: Antonio Meola

Academic Editor: Bart Ellenbroek

Special Issue: Tumors of the Central Nervous System

Received: May 05, 2019 | Accepted: May 05, 2019 | Published: May 08, 2019

OBM Neurobiology 2019, Volume 3, Issue 2, doi:10.21926/obm.neurobiol.1902025

Recommended citation: Meola A. Editorial: “A New Era in Neuro-Oncology”. OBM Neurobiology 2019;3(2):2; doi:10.21926/obm.neurobiol.1902025.

© 2019 by the authors. This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.

For several decades, the classification of brain tumors was based on histogenesis. Brain tumors were classified on the basis of their presumed cell of origin and differentiation stage. From a practical viewpoint, the characterization of brain tumors was traditionally based on light field microscopy and, more recently, on immunohistochemical assays and ultrastructural studies.

The 2016 WHO classification of tumors of the central nervous system [1] radically changed the rationale behind brain tumor classification. The 2016 classification is based both on the histological as well as the genetic and molecular features of brain tumors. As a consequence, some neuro-oncological categories were completely restructured, such as glioblastoma, medulloblastoma and embryologic tumors. Moreover, some new neuro-oncological entities were created, while other were removed from the classification. Certainly, our new knowledge about brain tumor biology and the development of modern molecular and genetic tests, allowed transitioning from a purely histological classification of brain tumors to a mixed histological and genetic/molecular classification. The new genetic and molecular features of brain tumors can have a tremendous impact on clinical practice, determining appropriate treatment selection, and patients’ prognosis.

In this new era of brain tumors, imaging plays a pivotal role, as well. The recent advancements in imaging techniques (i.e. MR spectroscopy, PET/CT) allow detecting molecular markers of brain tumors, which are associated with different histotypes. Thus, imaging will provide the clinician with important information about brain tumor histology, biology and prognosis.

The special issue on “Tumors of the Central Nervous System” of OBM Neurobiology, includes several important contributions highlighting contemporary concepts of brain tumor biology derived from novel molecular, genetic and radiological studies.

Author Contributions

The author did all the research work of this study.

References

  1. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 world health organization classification of tumors of the central nervous system: A summary. Acta Neuropathol. 2016; 131: 803-820. [CrossRef]
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