Table of Contents

Volume 3,Issue 3

Open Access Review

Transcranial Magnetic Stimulation: A Tool for Quantifying Neurophysiological Changes in the Brain Following Concussion Injury in Sports

Received: 05 July 2019;  Published: 27 September 2019;  doi: 10.21926/obm.neurobiol.1903042

Abstract

(1) Background: Sport-related concussion is a growing public health concern. Defined as a functional injury, concussion is characterised by a constellation of signs and symptoms. However, clinical imaging methods do not reveal any structural damage. Recently, neurophysiological techniques such as tr [...]

Open Access Research Article

The End Effector of Ischemic Tolerance Present in Blood Plasma from Double Conditioned Donors Ameliorates Trimethyltin Provoked Damage in Brain

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Abstract

Background: Hundreds of experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. The translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-methyltin poi [...]

Open Access Review

Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases

Received: 22 August 2019;  Published: 16 September 2019;  doi: 10.21926/obm.neurobiol.1903040

Abstract

Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

Open Access Review

Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Received: 11 August 2019;  Published: 09 September 2019;  doi: 10.21926/obm.neurobiol.1903039

Abstract

Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

Open Access Review

Hyperglycemia-Induced Brain Injury in Preterm Infants

Received: 29 May 2019;  Published: 29 August 2019;  doi: 10.21926/obm.neurobiol.1903038

Abstract

Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...]

Open Access Review

Extra Corporeal Life Support in Traumatic Brain Injury Patients

Received: 11 June 2019;  Published: 22 August 2019;  doi: 10.21926/obm.neurobiol.1903037

Abstract

Purpose of review: The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The charac [...]

Open Access Original Research

Characterisation of Oxidative Stress, DNA Damage and Inflammation in a Cellular Model of Parkinson’s Disease

Received: 13 March 2019;  Published: 01 August 2019;  doi: 10.21926/obm.neurobiol.1903036

Abstract

Background: Parkinson’s disease (PD) is the second most commonly occurring neurodegenerative disease and is classed as a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage. Methods: SH- [...]

Open Access Review

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Received: 07 May 2019;  Published: 29 July 2019;  doi: 10.21926/obm.neurobiol.1903035

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury and the mechanisms have not been completely found out yet. The causative factors of brain injury initiated by aneurysm rupture, which is called as early brain injury (EBI), consists of elevated intracranial pressure, cerebral hypo [...]

Open Access Review

Short Sleep in Pupils in Japan: Current Status and Associated Factors

Received: 21 February 2019;  Published: 22 July 2019;  doi: 10.21926/obm.neurobiol.1903034

Abstract

Background: Japan is the most sleepless nation in the world. This study aimed to understand short sleep pupils in Japan. Since academic performance is known to worsen with sleep problems, self-reported academic performance (s-rAP) was also investigated. Methods: A total of 1766 completed questionna [...]

Open Access Original Research

Melatonin Aggravated Oxaliplatin-Mimicking Sinusoidal Obstruction Syndrome: Role of Platelet Aggregation and Oxidative Stress

Received: 31 March 2019;  Published: 17 July 2019;  doi: 10.21926/obm.neurobiol.1903033

Abstract

(1) Background: Sinusoidal obstruction syndrome is a liver injury induced either by accidental ingestion of pyrrolizidine alkaloid monocrotaline or by chemotherapeutic drug oxaliplatin used for the treatment of colorectal cancer. Sinusoidal obstruction syndrome is characterized by rounding and swell [...]

Open Access Research Article

Daytime Sleepiness and the Well-Being and Academic Attainment of University Students in the UK

Received: 02 April 2019;  Published: 02 July 2019;  doi: 10.21926/obm.neurobiol.1903032

Abstract

Background: Previous research suggests that insufficient daily sleep has negative effects on both well-being and academic attainment. Much of the research in this field has focused on adolescents and children rather than university students in the UK. Methods: The present study used the Student Well [...]

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