OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 7 days from acceptance to publication (average values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Free Publication in 2019
Current Issue: 2019  Archive: 2018 2017
Open Access Review
Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Siavash Jafari 1, *, Mariko Vaughan 1, Souzan Baharlou 2, Pooria Ghadiri 3, Nazila Hassanabadi 4, Ashkan Nasr 5

1. Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

2. British Columbia Children’s Hospital, Vancouver, BC V6T 1Z3, Canada

3. Department of Family Medicine, McGill University, Montreal, QC, Canada

4. Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, QC, Canada

5. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Correspondence: Siavash Jafari

Academic Editor:  Steven I. Dworkin

Special Issue: Behavioral Neuropharmacology

Received: August 11, 2019 | Accepted: September 06, 2019 | Published: September 09, 2019

OBM Neurobiology 2019, Volume 3, Issue 3, doi:10.21926/obm.neurobiol.1903039

Recommended citation: Jafari S, Vaughan M, Baharlou S, Ghadiri P, Hassanabadi N, Nasr A. Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials. OBM Neurobiology 2019;3(3):12; doi:10.21926/obm.neurobiol.1903039.

© 2019 by the authors. This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.

Abstract

Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality.

Methods: We searched PubMed, Current Contents, Scopus, EMBASE, MEDLINE, the Effect Review Summary Database and the ACP Journal Club until May 2018. A randomized clinical trial examined the impact of case management on the association of PLHA with care and publications in English. After reviewing the title and abstract, the full text of the included study is retrieved for in-depth review. Two commentators reviewed the articles and extracted relevant information.

Results: Six randomized controlled trials were selected for inclusion in the systematic review. We found significant heterogeneity in the included studies. These studies use a wide range of definitions and provide a variety of services under case management services. One study found a statistically significant reduction in mortality and viral load reductions, but there was no difference in CD4 counts in the case management group. Two studies have found that case management patients are more closely linked to HIV care. Three studies found no difference in treatment initiation rates and treatment initiation time between the two groups. One study did not find an improvement in CD4 counts. One study reported an increase in viral load.

Conclusions: The results of this systematic review show mixed results on the impact of case management on the outcome of interest. The nature and level of case management services offered to participants varied significantly. Case management could improve the linkage to care among PLHA, improve their survival rate and reduce viral load however has no impact on CD4 levels.

Keywords

Access to care; adherence to care; linkage to care; HIV/AIDS; case management

1. Background

According to the estimates by the Centers for Disease Control and Prevention (CDC), approximately 37,000 new human immunodeficiency virus (HIV) infections occur each year in the United States [1,2]. The seroprevalence rate is even higher in some populations: especially African Americans, Hispanics and men who have sex with men are severely hit by HIV/AIDS people [3]. It is estimated that 21% of infected people do not know their serostatus [4]. People do not know that their serum status is more likely to engage in risk-free health behaviors such as unprotected sex [5]. People living with HIV/AIDS (PLHA) do not know their identity, accounting for more than half of new infections [5]. Conversely, when people know their HIV status, they are less likely to spread the disease, and studies have shown that patients with antiretroviral therapy (ART) are less contagious [3]. Lack of awareness can also lead to advanced HIV disease: 35% to 45% of newly diagnosed HIV-infected people develop AIDS within one year of diagnosis, representing late-stage care [3]. PLHA entering health care at this time is often extremely impaired, immune system and AIDS-related complications [3].

In Canada, the number of people infected with HIV/AIDS in 2014 is estimated at 75,000 [6]. An estimated 2,300 to 4,500 new HIV infections were reported in the same year [7]. The most common types of exposure in epidemics include MSM (51%), IDU (17%), heterosexual/non-endemic (15%), heterosexual/local (12%) and MSM-IDU (MSM-IDU) 4% [7]. Heterosexual/non-endemic was defined as contact with a person who is either HIV-infected or at risk for HIV, or heterosexual as the only identified risk and heterosexual/endemic was defined as non-IDU heterosexual with origin in a country where heterosexual sex is the predominant mode of HIV transmission and HIV prevalence is high (primarily countries in sub-Saharan Africa and the Caribbean).

Early diagnosis and connection to care for people living with HIV have a significant impact on their morbidity and mortality. Early initiation of HIV treatment and long-term adherence can lead to better health outcomes and reduce the spread of infection. Therefore, shortly after the diagnosis of HIV, contact with care can be an important intervention to improve prognosis and prevent transmission. Many people living with HIV are not linked to care or are not cared for after HIV diagnosis [8,9].

Case management was developed in the 1970s and it was adapted into HIV/AIDS care in 1980s. This is a multifaceted intervention to ensure timely access to and coordination of medical and psychosocial services for people living with HIV. Although there is no universal case management program, a case manager is usually assigned to people living with HIV to help them assess and prioritize needs such as health care, housing, finance, and social support. In this way, case management is considered to prevent hospitalization or long-term care from admission, and doing so helps control costs associated with health care. The goal of case management is to promote and support individual independence and self-sufficiency. Therefore, the case management process requires customers to actively participate in decision-making and support clients' self-determination, dignity and respect, non-discrimination, compassionate non-judgmental care, and culturally competent case management providers.

Regarding the impact of case management on the health outcomes of people living with HIV, there are publications such as CD4 levels, adherence to care, health-related quality of life, use of street drugs, admission rates, and participation in treatment options. However, the sample size of these studies was small, the study time was different, and the various results of interest were studied. A systematic review and a potential meta-analysis are needed to investigate the combined effects of case management on the medical and psychosocial outcomes of PLHA.

2. Objectives

The purpose of this systematic literature review is to investigate the impact of case management on the link between people living with HIV/AIDS (PLHA) and HIV care programs and to investigate the effect of case management for their overall morbidity and mortality.

3. Methods

3.1 Search Strategy

MEDLINE (1966 - May 2018), EMBASE (May 1980 - 2018), Impact Review Summary Database (May 1991 to 2018), PsychINFO (1988 to May 2018) and Web of Science (1961 to May 2018) a search was conducted to determine relevant studies. The initial search strategy was developed from the medical subject heading (MeSH) terminology case management and HIV in MEDLINE. We reviewed the titles related to this study and then adjusted and combined the topic titles and free-text terms. We searched for proceedings and conference abstracts through the databases PapersFirst (1993) and Proceedings First (1993) until May 2018. The author's name and the publication year of the main paper are entered into a reference search in the database Web of Science. For any articles that may be missing, the references to the retrieved research and review articles are screened. We also searched for journals related to HIV, Case Management, Epidemiology, and hepatitis-related abstracts and books. The following Medical Subject Headings (MeSH) were used to search to identify the relevant publications: case management, case managers, HIV infections, HIV-infected patients, HIV long-term survivors, health services accessibility, patient acceptance of health care, health services/utilization, health services needs and demand, patient care/utilization, primary health care/utilization, patient compliance, health services needs and demand, randomized controlled trial, and RCT.

We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to prepare this systematic review [10].

3.2 Selection Criteria

We included randomized controlled trials investigating the impact of case management on the linkage of PLHA to care and presenting odds ratios (OR) and their corresponding 95% confidence Interval (95% CI) or provided enough data to calculate these parameters. If a study was published at a different stage, or if the data was repeated in multiple publications, only the most recent study was included. We limit our research to articles that were published 1) in English; 2) were from the North America or Europe; and 3) had a randomized trial design. If the article was not fully published, we tried to contact the author to retrieve the full manuscript.

3.3 Data Extraction

We created a spreadsheet and recorded study characteristics, including author name, publication year, study country, study design, sample size, study population, mean age and/or age range, participant gender, risk factor type or adjusted confounding factors, interest outcomes, adjusted OR and 95% CI. Two reviewers independently (SJ and PG) conducted a comprehensive review of the articles included. For studies that provide multiple levels of exposure, each exposure is classified and analyzed in a designated subgroup. We collected data on factors such as CD4 counts, viral load and reduction in high-risk behavior as outcome measures to assess the potential impacts of linkage to care.

3.4 Quality Assessment

The included studies were assessed for the risk of quality and bias. The CONSORT Reporting Guide was used to evaluate the included studies. The Newcastle-Ottawa Scale was used to assess the quality of the included studies (Appendix S1).

4. Results

A total of 622 titles were reviewed, including 55 publications, in which six randomized controlled trials (RCTs) comprising of five from the United States, and one from Russia were included in the systematic reviews (see Figure 1).

Figure 1 Selection of studies for inclusion in the systematic review and meta-analysis.

Table 1 summarize the results of the included studies. All included studies registered PLHIV in their study. PLHIV who were enrolled in Buchanan (2009) has been homeless for several months before enrollment, and are English speakers and HIV-seropositive [11]. Gardner (2005) included PLHIV who have used a care provider once in the past and have not taken ARVs [12]. Gordon (et al, 2017) included HIV-infected prisoners who have not received treatment within 30 days of enrolment [13]. Wohl (2011) recruited HIV-infected prisoners [14].

Wohl (2006) studied the effects of case management on the viral load and the linkage between care and treatment-naive PLHIV, and also, PLHIV with no more than one failed HAART experience in the past [15]. In 2017, Samet et al. investigated the impact of case management on the links between HIV-based care and HIV care using intravenous (IV) drugs.

Most studies provide detailed information about the age and gender of the participants. All studies included men and women. Most studies reported the age of participants aged 18 or older [12,14]. However, in the study conducted by Buchanan 2009, Gordon 2017, Samet 2017 and Wohl 2006 [11,13,15,16], the age of the participants was not clear. In the Wohl 2006 and Wohl 2011 studies, the study took 6 months, and in the 2005 Gardner and Buchanan, a 12-month 2009 to 18-month study by Gordon 2017. All studies reported two or more encounters during the study period. The sample size ranged from 105 participants in Buchanan 2009 to 349 participants in the Samet study in 2017. The quality of the included studies was assessed using a standard scale. The quality of studies varies from 12 to 13.

Table 1 List of included studies.

4.1 Interventions Offered in the Included Studies

In 2009, Buchanan examined the impact of permanent housing and intensive case management of homeless people hospitalized with a chronic medical illness. A year after, 55% of the interventions and 34% of conventional care groups survived and had complete immunity (P = 0.04). Seventeen (36%) individuals from the intervention and nine (19%) individuals from the conventional care group had an undetectable viral load (P = 0.051). The median viral load in the intervention group was 0.89 log lower (P = 0.03). There was no statistical difference in CD4 counts.

Gardner 2005 uses a strength-based case management to require clients to identify their interval strength as assets and apply those resources to obtain the required resources. An intervention manual was developed and the ARTAS case manager was trained as a team prior to client`s registration. Participants were randomly divided into 2 groups. Those who only receive information and referred to as Standard of care (SOC) and are sent to the local HIV medical care provider. Participants in the intervention group were introduced to the case manager. The study found that a higher proportion of participants in the intervention group visited the HIV clinician (aRR 1.36; P = 0.0005) at least once within 6 months, at least twice within 12 months (aRR 1.41; P = 0.006).

In 2017, Gordon tested the project bridge model, a team-based care model that provides intensive case management for HIV patients as they transit from imprisonment to community. Gordon 2017 reported no difference in the rates of, or time to, treatment initiation between PB and TAU (both > 0.05), and there was no statistically significant difference between HIV treatment regimens under treatment conditions (p > 0.05).

In 2017, Samet found that 45% of the intervention group and 30% of the controls were linked to HIV care within 6 months after enrollment (aOR 2.20; 95% CI: 1.42-3.41; p = 0.0004). The mean CD4 counts at 12 months in the intervention and control groups were 340 and 372, respectively. (Adjusted mean difference: -20.2; 95% CI: -83.3, 42.9). They found no improvement in CD4 levels.

Wohl and colleagues [15] in their study found no difference in the linkage to care between the intervention group and the control group. There was no difference in the immune response between the two groups too. In the intent-to-treat analysis, they found no statistical difference in the percentage of patients who were unable to detect viral load at 6 months between the DAART group (54%), the IACM group (60%), and the SOC group (54%), P value = 0.05).

In another study, Wohl and colleagues [14] found that case management intervention to bridge incarceration and release were no more effective than a less intensive pre-release discharge planning program to support the health and social service utilization of people living with HIV who were released from prison.

4.2 Description of Case Management

In a Buchanan 2009 study, a case manager who was a social worker at the hospital saw patients in the intervention group. The person explained the intervention and provided a referral of temporary housing after discharge. Gardner 2005 describes case management as an attempt to establish relationships, identify and address clients’ needs and health care barriers, and encourage contact with clinics. In Gordon 2017, the study case management team consisted of a masters-level social worker who served as the case manager and a social worker who served as an outreach employee. Case Manager provided participants with many of their social and practical needs, with a focus on facilitating participation in HIV medical care. Case managers were responsible for overall case planning when conducting case reviews and conducting case conferences for all decisions that required clinical judgment.

Samet 2017 applied strength-based case management (LINC). Wohl 2006 provided no explanation of the case management services. Wohl 2011 used the behavioral model of the health service for vulnerable populations. The case management strengths model focuses on identifying the client's talents, resources, and goals in an open, non-judgmental environment. Prior to recruitment, Bridging Case Managers (BCMrs) underwent a series of group training led by experts in the model, as well as structured self-study and continuous clinical supervision, to maintain BCMrs' ability and loyalty to the model.

Gardner 2005 and Samet 2017 found a significant improvement in the linkage to care, while Wohl 2006 and Wohl 2011 found no differences in the linkage to care between the intervention group and control group. Two studies showed no improvement in CD4 and viral load [11,16]. Only one study investigated treatment initiation among PLHA inmates [13].This study found no improvement in the initiation of treatment. Buchanan 2009 examined the impact of case management on the mortality of PLHA and found a lower mortality rate in the case management group.

5. Discussion

The results of this systematic review show mixed results on the impact of case management on the outcome of interest.

The nature and level of case management services offered to participants varied significantly. For example, a 90-day study yielded up to 5 contacts with a case manager [12]. Wohl et al. (2006) provided "Intensive Adherence Case Management" (IACM), in which participants met weekly with a case manager to overcome barriers to HAART compliance, including referrals to healthcare payments, accommodation, drug abuse treatment, legal advice, and nutritional support [15].

The National Case Management Network of Canada (NCMN) defines case management as "a collaborative, client-focused process for delivering quality health and support services through the effective and efficient use of resources" [17]. This network has introduced a set of case management practice standards that must be followed to ensure the success of such programs. Case management includes client intake, needs analysis, service planning, service plan implementation, service coordination, monitoring and follow-up, reassessment, case conferencing, crisis intervention and case closure. Case management activities are diverse; in addition to assisting clients in accessing and maintaining specific services, they may also include negotiation and advocacy of services, provider consultation, service system navigation, psychosocial support, supportive counseling, and general client education.

Several potential risk factors for failure to link to care have been identified, including African-American race, residence in a high-poverty area, lack of insurance or public insurance (vs. private insurance), lack of primary care prior to HIV diagnosis, substance use, History of injection drug use and longer waiting time for the first appointment [18,19,20,21,22]. Case management can overcome such barriers by trying to connect clients to relevant services, assessing clients for potential risk factors, referring them to care providers, eliminating financial barriers, and reducing delays by simplifying appointments.

We used the Newcastle Ottawa Scale (NOS) to assess the quality of non-randomized studies in meta-analyses [23]. None of the studies provided the registration number of the clinical trial. We searched the Clinical Trial Registry and found no registration. In such research, the blinding of participants and researchers is impossible. All studies reported randomization process in their research.

In this systematic review, we were unable to perform a meta-analysis because the included studies examined a wide range of outcome measures and exhibited significant heterogeneity. However, detailed information on the methods and results of the included studies will allow us to use the results of this systematic review when considering case management as a potential service to PHLA. Based on the results of this systematic review, the Case Management PLHA offers some advantages. The extent of these benefits is not fully understood due to the heterogeneity and conflicting results of existing studies. Additional research is needed to clarify the benefits of case management for PLHA. Future research should be conducted using a clearer case management definition. A universal case management program would be ideal to enable better comparisons between studies.

Additional Materials

The following additional materials are uploaded at the web version of this paper.

Appendix S1: Consort 2010 checklist of information to include when reporting a randomised trial.

Author Contributions

Siavash Jafari: generated to original question and the idea of conducting a systematic review. He reviewed individual articles to decide on inclusion and exclusion. Also, he prepared the manuscript and all required editing. Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, and Ashkan Nasr performed articles search. They prepared the excel spread sheet and worked on data extraction. They are involved with deciding on inclusion and exclusion of articles. Mariko Vaughan and Pooria Ghadiri prepared the final graphs and table. Souzan Baharlou, Nazila Hassanabadi, and Ashkan Nasr assessed the quality of the studies.

Competing Interests

The authors have declared that no competing interests exist

References

  1. Smith-Rohrberg D, Mezger J, Walton M, Bruce RD, Altice FL. Impact of enhanced services on virologic outcomes in a directly administered antiretroviral therapy trial for HIV-infected drug users. J Acquir Immune Defic Syndr. 2006; 43: S48-S53. [CrossRef]
  2. Centers for Disease Control and Prevention (CDC). (2010). HIV in the United States. Available at: http:www.cdc.gov/hiv/resources/factsheets/PDF/us.pdf. Accessed July, 2015.
  3. Gardner EM, McLees MP, Steiner JF, del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011; 52: 793-800. [CrossRef]
  4. Centers for Disease Control and Prevention (CDC).(2009). HIV Surveillance Report. 21: Tables 20 and 21. Accessed August 2015. Available at: http:www.cdc.gov/hiv/topics/surveillance/resources/reports/.
  5. Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: Implications for HIV prevention programs. J Acquir Immune Defic Syndr. 2005; 39: 446-453. [CrossRef]
  6. Public Health Agency of Canada. Summary: Measuring Canada's Progress on the 90-90-90 HIV Targets. Surveillance and epidemiology division, professional guidelines and public health practice division, centre for communicable diseases and infection control, public health agency of Canada, 2016. Available from: http://healthycanadians.gc.ca/publications/diseases-conditions-maladies-affections/hiv-90-90-90-vih/index-eng.php.
  7. CCDR. (2006). Estimates of HIV prevalence and incidence in Canada, 2005. Accessed May, 2015. http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/06vol32/dr3215a-eng.php.
  8. Marks G, Gardner LI, Craw J, Crepaz N. Entry and retention in medical care among HIV-diagnosed persons: A meta-analysis. AIDS. 2010; 24: 2665-2678. [CrossRef]
  9. Ortego C, Huedo-Medina TB, Llorca J, Sevilla L, Santos P, Rodríguez E, Warren MR, Vejo J. Adherence to highly active antiretroviral therapy (HAART): A meta-analysis. AIDS Behav. 2011; 15: 1381-1396. [CrossRef]
  10. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann Intern Med. 2009; 151: 264-269. [CrossRef]
  11. Buchanan D, Kee R, Sadowski LS, Garcia D. The health impact of supportive housing for HIV-positive homeless patients: A randomized controlled trial. Am J Public Health. 2009; 99: S675-S680. [CrossRef]
  12. Gardner LI, Metsch LR, Anderson-Mahoney P, Loughlin AM, Del Rio C, Strathdee S, et al. Efficacy of a brief case management intervention to link recently diagnosed HIV-infected persons to care. AIDS. 2005; 19: 423-431. [CrossRef]
  13. Gordon MS, Crable EL, Carswell SB, Leopold J, Hodo-Powell J, McKenzie M, et al. A randomized controlled trial of intensive case management (project bridge) for HIV-infected probationers and parolees. AIDS Behav. 2018; 22: 1030-1038. [CrossRef]
  14. Wohl DA, Scheyett A, Golin CE, White B, Matuszewski J, Bowling M, et al. Intensive case management before and after prison release is no more effective than comprehensive pre-release discharge planning in linking HIV-infected prisoners to care: A randomized trial. AIDS Behav. 2011; 15: 356-364. [CrossRef]
  15. Wohl AR, Garland WH, Valencia R, Squires K, Witt MD, Kovacs A, et al. A randomized trial of directly administered antiretroviral therapy and adherence case management intervention. Clin Infect Dis. 2006; 42: 1619-1627. [CrossRef]
  16. Samet JH, Blokhina E, Cheng DM, Walley AY, Lioznov D, Chaisson C, et al. A strengths-based case management intervention to link HIV-infected PWID in Russia to HIV care–RCT results. Drug Alcohol Depend. 2017; 100: e181. [CrossRef]
  17. National Case Management Network of Canada. (2009). Canadian Standards of Practice for Case Management. Accessed May, 2015 at: http://www.ncmn.ca/resources/documents/english%20standards%20for%20web.pdf.
  18. Bell C, Metsch LR, Vogenthaler N, Cardenas G, Rodriguez A, Locascio V, et al. Never in care: characteristics of HIV-infected crack cocaine users in two US cities who have never been to outpatient HIV care. J Acquir Immune Defic Syndr. 2010; 54: 376. [CrossRef]
  19. Giordano TP, Visnegarwala F, White Jr AC, Troisi CL, Frankowski RF, Hartman CM, et al. Patients referred to an urban HIV clinic frequently fail to establish care: Factors predicting failure. AIDS Care. 2005; 17: 773-783. [CrossRef]
  20. Torian LV, Wiewel EW, Liu KL, Sackoff JE, Frieden TR. Risk factors for delayed initiation of medical care after diagnosis of human immunodeficiency virus. Arch Intern Med. 2008; 168: 1181-1187. [CrossRef]
  21. Tripathi A, Gardner LI, Ogbuanu I, Youmans E, Stephens T, Gibson JJ, et al. Predictors of time to enter medical care after a new HIV diagnosis: A statewide population-based study. AIDS Care. 2011; 23: 1366-1373. [CrossRef]
  22. Ulett KB, Willig JH, Lin H-Y, Routman JS, Abroms S, Allison J, et al. The therapeutic implications of timely linkage and early retention in HIV care. AIDS Patient Care STDS. 2009; 23: 41-49. [CrossRef]
  23. Wells G SB, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P. (2013). The Newcastle-Ottawa Scale (NOS) for assessing the quality of non randomised studies in meta-analyses. http://wwwohrica/programs/clinical_epidemiology/oxfordasp.
Newsletter
Download PDF Supplementary File
0 0

TOP