OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

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Rapid publication: manuscripts are undertaken in 6 days from acceptance to publication (median values for papers published in this journal in the first half of 2020, 1-2 days of FREE language polishing time is also included in this period). A first decision provided to authors of manuscripts submitted to this journal are approximately 3.7 weeks (median values) after submission.

Current Issue: 2020  Archive: 2019 2018 2017
Open Access Editorial
Liver Transplantation in Pediatrics

Yasuhiko Sugawara *

Department of Transplantation/ Pediatric Surgery, Postgraduate School of Life Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 8603-8556, Japan

Correspondence: Yasuhiko Sugawara

Special Issue: Pediatric Liver Transplantation

Received: May 15, 2020 | Accepted: May 15, 2020 | Published: May 18, 2020

OBM Transplantation 2020, Volume 4, Issue 2, doi:10.21926/obm.transplant.2002111

Recommended citation: Sugawara Y. Liver Transplantation in Pediatrics. OBM Transplantation 2020;4(2):3; doi:10.21926/obm.transplant.2002111.

© 2020 by the authors. This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.

Keywords

Liver transplantation; living donor; hepatocellular carcinoma

Since the first case, which was indicated for biliary atresia by Starzl in 1967, the pediatric liver transplantation has gradually developed so far. The 5-year survival rate is currently around 85–90% in well-established centers of pediatric liver transplantation [1].

Apparently, liver transplantation has now become the standard treatment for the children with chronic end-stage liver disease, tumors (hepatocellular carcinoma, hepatoblastoma), metabolic diseases, and acute liver failure [2]. The techniques to harvest and procure split-liver grafts from deceased or living donors have been refined. The availability of organs has increased, and the waitlist mortality of the patients has decreased. Around 90% of the patients on the waitlist now eventually undergo liver transplantation [1].

The postoperative care has been well optimized by the introduction of a multidisciplinary team consisting of transplant surgeons, pediatricians, pediatric transplant hepatologists, transplant coordinators, psychologists, and social workers [3]. The clinical efforts have shifted from preventing mortality to improving the morbidity with satisfactory postoperative outcome. It is important to tailor the immunosuppressive drugs to prevent acute or chronic cellular rejection or antibody-mediated rejection. It can also contribute to avoiding infection and posttransplant lymphoproliferative disease. The patients must be closely followed up, and the liver enzymes, function, and immunosuppressive drug levels should be monitored. Adherence to the medication is sometimes challenging in adolescents and young adults, and at the same time, nonadherence results in rejection and graft loss.

An interesting issue is that some children can be introduced to the operational tolerance. According to the multicenter trials on the withdrawal of the immunosuppressive drugs, a successful tolerance rate of approximately 60%, in the selected recipients based on a biochemical and histological basis, was observed [4].

Author Contributions

YS proposed the study and wrote the draft.

Funding

No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

Competing Interests

The author declared no conflict of interest.

References

  1. Cuenca AG, Kim HB, Vakili K. Pediatric liver transplantation. Semin Pediatr Surg. 2017; 26: 217-223. [CrossRef]
  2. Pham YH, Miloh T. Liver Transplantation in Children. Clin Liver Dis. 2018; 22: 807-821. [CrossRef]
  3. Spada M, Riva S, Maggiore G, Cintorino D, Gridelli B. Pediatric liver transplantation. World J Gastroenterol. 2009; 15: 648-674. [CrossRef]
  4. Feng S, Bucuvalas J. Tolerance after liver transplantation: Where are we? Liver Transpl. 2017; 23: 1601-1614. [CrossRef]
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