Table of Content

Open Access Review

Neuroprotective Potentials of Honey for Cerebral Small Vessel Disease

Received: 31 July 2022;  Published: 14 November 2022;  doi: 10.21926/obm.neurobiol.2204144


The nectar produced by bees in nature is known as honey and has been consumed for its nutritional and medicinal properties. There is growing evidence that honey and its compounds have anti-inflammatory, antioxidant and anti-microbial properties that are relevant to the maintenance of health and the prevention of illnesses, including cardiocerebrovascular disease. Cerebral small vessel disease (CSVD) is one of the major risk factors for diseases such as stroke, dementia, Alzheimer’s disease, and Parkinson’s disease. [...]

240 3123

Open Access Review

Dynamic Resting-State Functional Connectivity in Migraineurs

Received: 19 July 2022;  Published: 26 October 2022;  doi: 10.21926/obm.neurobiol.2204143


Functional magnetic resonance imaging (fMRI) is widely used to detect changes in the resting-state brain networks of migraine patients. Functional connectivity fMRI analysis examines the functional organization of the brain based on temporal correlations of blood oxygen level-dependent signal changes in different brain regions. Most previous resting-state fMRI studies have assumed that functional connectivity between brain regions remains relatively stable over time. However, it is now known that the brain is a com [...]

248 2090

Open Access Original Research

An Empirical Study on the Communication and Usage Psychology of Emoji in Wechat

Received: 30 June 2022;  Published: 17 October 2022;  doi: 10.21926/obm.neurobiol.2204142


As an indispensable active atmosphere and meaningful emotional expression in social media, emojis describe the emotions of users in specific situations in a funny, humorous, euphemistic, and implicit form and attract users to use them consciously or unconsciously with their quick and convenient features. Currently, the research on the psychology of emoji usage is mostly from the perspective of users, while neglecting the essential attributes of emojis. The purpose of this study was to investigate and summarize the [...]

303 3307

Open Access Original Research

Challenges and Problems on Self-directed Learning Readiness in Non–face-to-face Educational Settings During COVID-19

Received: 15 June 2022;  Published: 08 October 2022;  doi: 10.21926/obm.neurobiol.2204141


This study aimed to verify whether self-directed learning readiness (SDLR) level can be significantly predicted by the literacy of learning management system (LLMS), motivation, and feedback interaction (FI) in non–face-to-face educational settings. We performed Pearson’s correlation analysis and multiple regression analysis. A total of 206 online college students responded to this web survey using simple random sampling. Results showed that three variables (LLMS, motivation, and FI) were positively associated with [...]

240 3984

Open Access Original Research

Possible Preventive Effect of Ziziphora clinopodioides Lam. Essential Oil on Some Neurodegenerative Disorders

Received: 10 June 2022;  Published: 08 October 2022;  doi: 10.21926/obm.neurobiol.2204140


The present article describes some characteristics of the effect of essential oil (EO) extracted from Ziziphora clinopodioides harvested from Armenian highlands on microglial cell lines (BV-2 wild-type (WT) and acyl-CoA oxidase1 (ACOX1)-deficient (Acox1–/–) cells). The mutant cell line was used as a model to investigate cellular oxidative damage following EO treatment. The main components of the tested EO were pulegone, isomenthone, 1,8-cineole, piperitone, and neomenthole, with concentrations of 42.1%, 9.7%, 8.22% [...]

186 2012

Open Access Original Research

Human Attention Assessment Using A Machine Learning Approach with GAN-based Data Augmentation Technique Trained Using a Custom Dataset

Received: 27 May 2022;  Published: 04 October 2022;  doi: 10.21926/obm.neurobiol.2204139


Human–robot interactions require the ability of the system to determine if the user is paying attention. However, to train such systems, massive amounts of data are required. In this study, we addressed the issue of data scarcity by constructing a large dataset (containing ~120,000 photographs) for the attention detection task. Then, by using this dataset, we established a powerful baseline system. In addition, we extended the proposed system by adding an auxiliary face detection module and introducing a unique GAN [...]

251 2448

Open Access Original Research

A Clinical Validity-Preserving Machine Learning Approach for Behavioral Assessment of Autism Spectrum Disorder

Received: 31 May 2022;  Published: 30 September 2022;  doi: 10.21926/obm.neurobiol.2203138


Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved the clinical relevan [...]

283 2505

Open Access Original Research

Computerized Assessment of Cognitive Development in Neurotypical and Neurodivergent Children

Received: 05 July 2022;  Published: 28 September 2022;  doi: 10.21926/obm.neurobiol.2203137


This study aims to observe the differences in the shared intentionality magnitude in mother-child dyads with neurotypical (NT) children and neurodivergent (ND) children aged 3-6 years. The quality of shared intentionality in infancy is associated with cognitive development. Our results showed that ND children scored six times higher (on average) in quiz-test than NT children. Children with difficulties in interaction (ND children) are more likely to use shared intentionality in conversation than NT children. We bel [...]

242 2733

Open Access Research Article

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats

Received: 29 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203135


Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and Cd [...]

179 2148

Open Access Interview

An Interview with Dr. Francisco J. Barrantes

Received: 22 September 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203136

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