TY  - JOUR
AU  - Fossel, Michael
AU  - Whittemore, Kurt
PY  - 2021
DA  - 2021/02/03
TI  - Telomerase and Cancer: A Complex Relationship
JO  - OBM Geriatrics
SP  - 156
VL  - 05
IS  - 01
AB  - Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis and, ultimately, clinical cancer. Telomerase therapy is not only un-likely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase therapy. Review of available data suggests that cancer should not be considered a significant risk to patients undergoing telomerase therapy.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2101156
DO  - 10.21926/obm.geriatr.2101156
ID  - Fossel2021
ER  -