TY  - JOUR
AU  - Nydegger, Urs
AU  - Imbach, Paul
PY  - 2025
DA  - 2025/01/23
TI  - Platelet Immune Interactions, Lifespan, and Senescence
JO  - OBM Geriatrics
SP  - 297
VL  - 09
IS  - 01
AB  - In addition to their hemostatic functions, platelets play an essential role in immunologic interactions, which is confirmed by the observation of an increase in platelet counts in patients with immune-related thrombocytopenia and other autoimmune diseases after immunomodulatory treatment with intravenous human immunoglobulin concentrate. The mechanisms of action of this biological therapeutic option induce the development of therapeutic monoclonal antibodies, agonists, and antagonists that target the complex pathophysiology of the innate and adaptive immune systems. Platelets play an essential role in severe adenovirus infection and adenovirus-based vaccination. Activated platelets have a shorter lifespan and early senescence in many diseases. Laboratory findings, such as senescence-associated secretory phenotypes, may lead to new biologic options for developing remedies for particles of platelets, named senolytics. The causative factors influencing platelet lifespan were also discussed.
SN  - 2638-1311
UR  - https://doi.org/10.21926/obm.geriatr.2501297
DO  - 10.21926/obm.geriatr.2501297
ID  - Nydegger2025
ER  -