Welcome to the new academic journal OBM Hepatology and Gastroenterology. Recent progress in understanding liver, biliary, pancreatic and gastro-intestinal diseases and their treatments has been observed in the world. OBM Hepatology and Gastroenterology publishes interesting and informative reviews, original articles, and invaluable case reports in this area. We also publish basic research as well as clinical research.

Hepatitis A virus (HAV), HBV, HCV, HDV, and HEV are still a serious issue worldwide. Treatments on these viruses have recently improved. However, liver fibrosis, cirrhosis and hepatocellular carcinoma are still critical conditions. We focus on all of these liver diseases. We also focus on broad-spectrum of gastro-intestinal diseases in this journal.

Please accept our special thanks for choosing to publish in the OBM Hepatology and Gastroenterology. We are looking forward to your submissions for OBM Hepatology and Gastroenterology.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 6.8 days from acceptance to publication (median values for papers published in this journal in 2020, 1-2 days of FREE language polishing time is also included in this period).

Free Publication in 2021

Open Access Review

Piperine: A Savor Inducer and a Cancer Reducer

Received: 26 July 2021;  Published: 15 September 2021;  doi: 10.21926/obm.hg.2103061

Abstract

Spices have been used for many decades, and although new and improved culinary spices have been developed, black pepper (Piper nigrum) continues to retain its distinguished title as the “King of spices” due to its particular pungent taste. An alkaloid called [...]

Open Access Review

Gastro-Esophageal Reflux in the Newborn: Pathologic Event or Does Spit Happen?

Received: 19 April 2021;  Published: 13 August 2021;  doi: 10.21926/obm.hg.2103060

Abstract

Infants admitted to Neonatal Intensive Care Units (NICUs) are among the most vulnerable patients in medicine and are at risk for a variety of morbidities, many of which require pharmacologic therapy. Gastroesophageal Reflux Disease (GERD) is a common diagnosis in the NICU patient populat [...]

Open Access Review

Non-Celiac Gluten Sensitivity in Children: Controversial Role of Gluten and Diagnostic Enigma

Received: 07 July 2021;  Published: 22 July 2021;  doi: 10.21926/obm.hg.2103059

Abstract

Non-celiac gluten sensitivity (NCGS) is a debatable condition that affects less than 6% of children. The absence of specific diagnostic markers and standardized diagnostic procedures make the diagnosis of NCGS challenging, covering patients with different and varied symptoms. Generally, [...]

Open Access Original Research

The Timing of Endoscopic Evaluation of Anti-TNFα Therapy Patients with Ulcerative Colitis

Received: 10 August 2020;  Published: 09 July 2021;  doi: 10.21926/obm.hg.2103058

Abstract

Anti-TNFα Therapy are used to induce remission and as maintenance therapy in refractory ulcerative colitis (UC) to achieve mucosal healing (MH). However, the time at which mucosal healing [...]

Open Access Case Report

Varicella-Zoster Gastritis in a Liver Transplant Patient: A Call to Attention

Received: 01 March 2021;  Published: 21 June 2021;  doi: 10.21926/obm.hg.2102057

Abstract

The reactivation of the Varicella-zoster virus (VZV) is a rare cause of acute gastritis in adults. About 30 cases have been reported in the literature, mostly with immunocompromised patients and mainly after bone marrow transplantation or during the development of malignant hematological [...]

Open Access Review

The Effects of Mediterranean Diet on the Human Gut Microbiota; a Brief Discussion of Evidence in Humans

Received: 09 November 2020;  Published: 05 February 2021;  doi: 10.21926/obm.hg.2101056

Abstract

The Mediterranean diet (MD) is considered one of the healthiest dietary patterns due to its rich provision of phytochemicals, antioxidants, vitamins, fiber, polyunsaturated, omega-3, and short-chain fatty acids through a variety of foods. The supply of such nutrients and bioactive components can sup [...]

Open Access Commentary

Deconstructing then Priming Gut Microbiota Resilience

Received: 11 December 2020;  Published: 01 February 2021;  doi: 10.21926/obm.hg.2101055

Abstract

The human intestinal microbiota represents a complex microbial community that plays an essential role in the maintenance of host health. Over the last decade, metagenomic and metabolomic analyses have revealed the influence of intestinal microbial diversity and composition on a range of biological f [...]

Open Access Editorial

Acknowlegement to Reviewers of OBM Hepatology and Gastroenterology in 2020

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.hg.2101054

Abstract

The editors of OBM Hepatology and Gastroenterology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer [...]

Open Access Original Research

Multi-Species Probiotic Modulates Cytokine Production and the Interplay between Immune and Colon Cancer Cells

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053

Abstract

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1 [...]

Open Access Review

The Physiology of Esophageal Reflexes

Received: 17 August 2020;  Published: 02 November 2020;  doi: 10.21926/obm.hg.2004052

Abstract

Several digestive tract reflexes involving the esophagus and its sphincter muscles have been identified, but to date, no comprehensive review has addressed most of these reflexes. The current review presents the known physiology of different esophageal reflexes in which either the esophagus or its s [...]

Open Access Case Report

Porto-Sinusoidal Vascular Disease with Obliterative Portal Venopathy Associated with Long-Term Azathioprine for Crohn’s Disease

Received: 04 March 2020;  Published: 25 September 2020;  doi: 10.21926/obm.hg.2003051

Abstract

Patients receiving immunosuppressive therapy for inflammatory bowel disease may be susceptible to non-cirrhotic portal hypertension, now referred to as porto-sinusoidal vascular disease. Here we describe a patient treated with long-term azathioprine for Crohn’s disease who developed porto-sinusoidal [...]

Open Access Review

Human Gut Microbiota: Friend or Foe?

Received: 06 March 2020;  Published: 07 August 2020;  doi: 10.21926/obm.hg.2003050

Abstract

The human gut is a house to approximately 1,000 different species of bacteria. The bacterial composition of gut microbiota is influenced by several factors, including age, sex, mode of delivery, geographical location, ethnicity, diet, drugs, and administration of prebiotics and/or probiotics. Simila [...]

Open Access Review

Use of Organs from Hepatitis C Viremic Donors: Addressing the Needs of a Changing Waitlist and the Effect of a Public Health Crisis

Received: 14 May 2020;  Published: 20 July 2020;  doi: 10.21926/obm.hg.2003049

Abstract

The combination of broad screening initiatives and development of effective antiviral therapies have led to a revolution in the treatment of hepatitis C virus and has reduced the proportion of patients with the virus who develop a need for liver transplantation in favor of other etiologies, such as [...]

Open Access Original Research

Prevalence of Chronic Constipation and Irritable Bowel Syndrome, and their Overlap, among Female Undergraduate Students in Japan

Received: 10 April 2020;  Published: 19 May 2020;  doi: 10.21926/obm.hg.2002048

Abstract

Chronic constipation and irritable bowel syndrome (IBS) are two of the most common functional gastrointestinal disorders, both of which negatively affect the quality of life of the patients. Since people may have co-existing symptoms of multiple disorders, chronic constipation and IBS with predomina [...]

Open Access Original Research

Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047

Abstract

Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hypergl [...]

Open Access Review

Can HCV Viremic Organs Be Used in Liver Transplantation to HCV Negative Recipients?

Received: 02 February 2020;  Published: 24 April 2020;  doi: 10.21926/obm.hg.2002046

Abstract

Liver transplantation has steadily increased worldwide resulting in a large number of patients on the waiting list. Due to the opioid epidemic in the US, the pool of Hepatitis C seropositive donors increased significantly in recent years. Direct acting antivirals played an instrumental role in makin [...]

Open Access Review

Low Prevalence of Spontaneous Bacterial Peritonitis in Ambulatory Asymptomatic Cirrhotic Patients: Consequences in Patients’ Care

Received: 21 August 2019;  Published: 15 April 2020;  doi: 10.21926/obm.hg.2002045

Abstract

The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-re [...]

Open Access Opinion

Vitamin D in Patients with Chronic Hepatitis C Virus Infection Receiving the Direct Antiviral Agents

Received: 23 February 2020;  Published: 30 March 2020;  doi: 10.21926/obm.hg.2001044

Open Access Comment

On the Pathogenesis of Crohn´s Disease

Received: 07 February 2020;  Published: 09 March 2020;  doi: 10.21926/obm.hg.2001043

Open Access Review

Endoscopic Therapy for Recurrent Acute Pancreatitis

Received: 17 October 2019;  Published: 23 December 2019;  doi: 10.21926/obm.hg.1904042

Abstract

Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found [...]

Open Access Original Research

The Daclatasvir/Asunaprevir/Beclabuvir Combination Therapy for Chronic Hepatitis C Patients Experiencing Failure of IFN-Free DAA-Based Therapies

Received: 29 September 2019;  Published: 17 December 2019;  doi: 10.21926/obm.hg.1904041

Abstract

Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV/BCV in patients experiencing treatment failure with interfer [...]

Open Access Case Report

Hypereosinophilia with Gastrointestinal Involvement: A Case Report

Received: 29 September 2019;  Published: 22 November 2019;  doi: 10.21926/obm.hg.1904040

Abstract

Hypereosinophilic syndrome is currently defined by an absolute blood eosinophil count of more of 1500 cell per μL for more than 1 month and by multiorgan system infiltration. Eosinophilic colitis is an exceptionally rare inflammatory condition in which eosinophils infiltrate the colonic gut. It repr [...]

Open Access Review

Platelet Function in Experimental Models of Liver Cirrhosis

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

Abstract

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of f [...]

Open Access Case Report

Primary Pancreatic-Type Acinar Cell Carcinoma of Jejunum Arising from Ectopic Pancreas with Synchronous Metastasis to Left Adrenal Gland

Received: 08 July 2019;  Published: 28 October 2019;  doi: 10.21926/obm.hg.1904038

Abstract

Background: Pure pancreatic-type ACC outside the pancreas is extremely rare. Methods: We presented a very rare case of primary ACC of the pancreatic-type involving jejunum with a synchronous metastasis to left adrenal gland arising in well-developed ectopic pancreas which had fully developed pancre [...]

Open Access Case Report

Partial Response of Alopecia Areata to Helicobacter Pylori Eradication and Treatment with Low-Dose Naltrexone

Received: 26 June 2019;  Published: 30 September 2019;  doi: 10.21926/obm.hg.1903037

Abstract

Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The i [...]

OBM Hepatology and Gastroenterology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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