TY  - JOUR
AU  - Alvarez, Francisco J.
AU  - Alvarez, Antonia A.
AU  - Lafuente, Hector
AU  - Alonso-Alconada, Daniel
AU  - Blanco-Bruned, Jose L.
AU  - Santaolalla, Francisco
AU  - Hilario, Enrique
PY  - 2019
DA  - 2019/11/15
TI  - Relationship between Brain Injury and Clinical Biomarkers in Hypoxic-Ischemic Newborn Piglets
JO  - OBM Neurobiology
SP  - 045
VL  - 03
IS  - 04
AB  - (1) Background: Newborn affected by hypoxic-ischemic brain injury can die and the survivors suffer neurodevelopmental handicaps. Biomarkers are needed to identify the severity of hypoxic-ischemic insult in order to early determine the rescue treatment. The aim of this study was to correlate the pathophysiological process and the severity degree of the hypoxic-ischemic brain injury with relevant biomarkers in a piglet model at short and medium term.
(2) Methods: Hypoxia-ischemia was induced by clamping of both carotid arteries and lowering oxygen in piglets. The half of animal groups, hypoxic-ischemic (HI) and sham, were sacrificed at 6 hours, and the other half after 72 hours. Brain tissue oxygen index (TOI) and amplitude-integrated electroencephalography (aEEG) were recorded. Fronto-parietal cortex and hippocampus sections stained for Nissl, TUNEL and glial fibrillary acidic protein (GFAP) were studied. Mean values were compared using a one-way analysis of variance for unpaired data (p
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.1904045
DO  - 10.21926/obm.neurobiol.1904045
ID  - Alvarez2019
ER  -