TY  - JOUR
AU  - Kouhakan, Faezeh
AU  - Ganjalikhan, Sepideh
AU  - Sarhadizadeh, Alireza
AU  - Esmaeilpour, Khadijeh
AU  - Akbari, Khatereh
AU  - Jafaripour, Leila
AU  - Asadi-Shekaari, Majid
PY  - 2024
DA  - 2024/04/23
TI  - Oleuropein can Protect the Brain Against Deleterious Effects of Bile Duct Ligation in Male Mice
JO  - OBM Neurobiology
SP  - 218
VL  - 08
IS  - 02
AB  - Oleuropein (OP) is a phenolic compound in olives. OP possesses potent antioxidant activity and an extensive spectrum of other pharmacological properties, including antiviral, anti-inflammatory, and antimicrobial activities. This study investigated the effects of OP on neural injuries caused by bile duct ligation (BDL) in male mice. The mice were randomly allocated to three groups: sham, BDL, and BDL + OP. Neurobehavioral tests histological and biochemical evaluations were accomplished to assess cerebral damage. The results demonstrated that the induction of BDL led to behavioral impairments and a rise in hepatic enzymes, and OP could protect the brain against BDL-induced injuries. OP significantly increased antioxidant enzymes. These results suggested that OP has valuable effects in the mice BDL model, probably due to its anti-inflammatory and antioxidant properties.
SN  - 2573-4407
UR  - https://doi.org/10.21926/obm.neurobiol.2402218
DO  - 10.21926/obm.neurobiol.2402218
ID  - Kouhakan2024
ER  -