TY - JOUR AU - Raele, Maria Vittoria AU - Dell’Anna, Laura AU - Mancini, Rachele AU - Farì, Giacomo AU - Ranieri, Maurizio AU - Megna, Marisa AU - Marvulli, Riccardo AU - Paoloni, Marco AU - Agostini, Francesco AU - Mangone, Massimiliano AU - Bernetti, Andrea PY - 2025 DA - 2025/02/27 TI - Therapeutic Exercise Holds the Key to Improve Hand and Upper Limbs Dystonia Rehabilitation Programs: A Systematic Review JO - OBM Neurobiology SP - 272 VL - 09 IS - 01 AB - Upper limb dystonia is a focal locomotion disorder affecting arm, forearm, and hand muscles, causing abnormal movements given by repeated, steady, and intercontinuous contractions. There are different types of dystonia and the multifaced nature of this pathology is challenging in the treatment management, leading to a worsening of affected patients’ life quality, mainly from a psychological point of view, but also from a functional perspective. This work examines the present literature regarding upper limb dystonia rehabilitation and treatment with a glance at recent approaches and new treatment strategies. This systematic review was carried out according to the PRISMA statement. The investigation used PubMed, Cochrane, and Google Scholar, including papers from the last ten years. The search yielded 1608 records, all undergone careful screening. A total of 15 papers were selected. The data highlight the importance of combined and customized treatments. The most common strategy included botulinum toxin. Evidence has shown the association between botulinum toxin and therapeutic exercise or occupational therapy. Other approaches involved: tDCS, rTMS and orthosis use, always combined with rehabilitation programs. This pathology requires a multidimensional approach combining personalized therapeutic exercise and other treatments. Nevertheless, further investigations are needed, with a larger population and standardized outcomes to improve dystonia patients’ quality of life and motor abilities. SN - 2573-4407 UR - https://doi.org/10.21926/obm.neurobiol.2501272 DO - 10.21926/obm.neurobiol.2501272 ID - Raele2025 ER -