TY  - JOUR
AU  - Tucker, Jared
AU  - Lai, Victor
PY  - 2024
DA  - 2024/12/17
TI  - Mechanical Characterization of a Tunable 3-D Collagen-Hyaluronic Acid Hydrogel for Use in Cell Culture
JO  - Recent Progress in Materials
SP  - 028
VL  - 06
IS  - 04
AB  - Many cells demonstrate variances in behavior due to their cell culture environment. To provide a mechanically-tunable, tissue-like environment, a 3D hydrogel for cell culture was formulated using collagen (Col) and hyaluronic acid (HA) to help provide a system for studying these dynamic cellular responses in a soft-tissue environment. A design of experiments was organized to study the effects of collagen concentration, HA fragment size, and Col: HA mass ratio on the hydrogel mechanical properties. Mechanical characterization of the gels was conducted using rheology and found that collagen concentration, but not HA content, directly modulated the hydrogel storage and loss modulus. The pore size of the hydrogels was also evaluated and found to trend directly with collagen concentration.
SN  - 2689-5846
UR  - https://doi.org/10.21926/rpm.2404028
DO  - 10.21926/rpm.2404028
ID  - Tucker2024
ER  -