OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor.
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Intestinal and Multivisceral Transplantation: Current Status and Future Directions
Submission Deadline: November 30, 2022 (Open) Submit Now
Pierpaolo Di Cocco, MD, PhD, Assisting Professor
Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA
Research Interests: Multi-Organ Abdominal Transplantation (liver, kidney and pancreas); Islet Cell Transplantation; Kidney and pancreas transplantation
About This Topic
Current guidelines restrict intestinal and multivisceral transplantation to patients with significant complications from parenteral nutrition including liver failure and repeated infections. Since the description of the first multivisceral transplantation by Thomas Starzl in an animal model more than 60 years ago and in humans 30 years later, the field has come a long way with more than 2000 procedure performed worldwide according to the most recent report of the Intestinal Transplant Registry. The broader term present in the literature of composite visceral transplantation encompasses MVT and any other combination of the visceral allograft with en bloc inclusion of the liver and/or pancreas. Two main variants are performed: full MVT (includes liver, stomach, duodenum, pancreas, small bowel) and modified MVT (graft does not include liver). Significant progress in the standardization of surgical techniques and immunosuppression has led to improved outcomes after transplantation with many patients returned to full functional status and enjoying long-term survival. As a consequence, over the past 2 decades, indications for these procedures have been steadily expanding. However, the absence of standardization regarding the indications makes difficult to interpret the results. Better understanding of the complex decision-making process in the selection of the type of allograft is key for further expansion of the field.
Continuous advancements in the medical management, immunosuppressive therapy, optimization of feeding and nutrition, will allow improvements in patient care and survival in this highly complex patient population.
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