OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).
Epigenetics of Obesity and Diabetes: Emerging roles and mechanisms of non-coding RNAs
Submission Deadline: April 15, 2020 (Open) Submit Now
Mohamed Zaiou, PhD/HDR, Professor
University of Lorraine, School of Pharmacy 7, Avenue de la Foret de Haye, 54501 Vandoeuvre lès Nancy, France
Research Interests: Molecular biology and cell biology applied to metabolic diseases; molecular genetics; epigenetics; biomarkers.
About This Topic
Our Special issue entitled “Epigenetics of Obesity and Diabetes: Emerging roles and mechanisms of non-coding RNAs” aims to cover all the latest and outstanding developments in the field of obesity and diabetes mellitus. Focus will be laid on the potential implication of genetic variations, environmental risk factors, and lately epigenetics mechanisms in the etiology of these complex and probably related disorders.
From genetic aspects, many genes have been known to influence the phenotypes of obesity and diabetes. Several studies have proposed genetic variants as biomarkers for predicting and diagnosing obesity and diabetes.
Different elements of the environment have also been posited to influence the pathogenesis of obesity and diabetes. In this respect, environment factors may trigger the genetic predisposition, thus, multiple mechanistic pathways may come into play.
Epigenetic changes including dysfunction of non-coding RNAs (miRNAs, lncRNAs, and circRNAs) control gene activity. Epigenome is one of the mechanisms linking environmental factors to altered gene activity. Further, epigenetic signatures obtained from human tissues are of relevance for metabolism in relation to obesity and type 2 diabetes mellitus (T2DM). Hence, the reversible nature of epigenetic changes holds promise as a cure for obesity and T2DM.
This special issue will mainly focus on new research that brings insights into interplays between genetics causes, epigenetic mediators (miRNAs, lncRNAs and circRNAs) and the environment triggers to influence obesity and diabetes. Understanding how these interplays can be orchestrated might provide an open field not only for discovery of targets for future therapeutics strategies in obesity and T2D but also for predicting their related vascular complications.