Special Issue

Epigenetics of Obesity and Diabetes: Emerging roles and mechanisms of non-coding RNAs

Submission Deadline: December 31, 2020 (Closed) Submit Now

Guest Editor

Mohamed Zaiou, PhD/HDR, Professor

University of Lorraine, School of Pharmacy 7, Avenue de la Foret de Haye, 54501 Vandoeuvre lès Nancy, France

Website | E-Mail

Research Interests: Molecular biology and cell biology applied to metabolic diseases; molecular genetics; epigenetics; biomarkers.

About This Topic

Our Special issue entitled “Epigenetics of Obesity and Diabetes: Emerging roles and mechanisms of non-coding RNAs” aims to cover all the latest and outstanding developments in the field of obesity and diabetes mellitus. Focus will be laid on the potential implication of genetic variations, environmental risk factors, and lately epigenetics mechanisms in the etiology of these complex and probably related disorders.

From genetic aspects, many genes have been known to influence the phenotypes of obesity and diabetes. Several studies have proposed genetic variants as biomarkers for predicting and diagnosing obesity and diabetes.

Different elements of the environment have also been posited to influence the pathogenesis of obesity and diabetes. In this respect, environment factors may trigger the genetic predisposition, thus, multiple mechanistic pathways may come into play.

Epigenetic changes including dysfunction of non-coding RNAs (miRNAs, lncRNAs, and circRNAs) control gene activity. Epigenome is one of the mechanisms linking environmental factors to altered gene activity. Further, epigenetic signatures obtained from human tissues are of relevance for metabolism in relation to obesity and type 2 diabetes mellitus (T2DM). Hence, the reversible nature of epigenetic changes holds promise as a cure for obesity and T2DM.

This special issue will mainly focus on new research that brings insights into interplays between genetics causes, epigenetic mediators (miRNAs, lncRNAs and circRNAs) and the environment triggers to influence obesity and diabetes. Understanding how these interplays can be orchestrated might provide an open field not only for discovery of targets for future therapeutics strategies in obesity and T2D but also for predicting their related vascular complications.

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (genetics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

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Publication

Open Access Editorial Epigenetics of Obesity and Diabetes: Emerging Roles and Mechanisms of Non-coding RNAs by Mohamed Zaiou Received: 16 March 2020;  Published: 17 March 2020;  doi: 10.21926/obm.genet.2001105