Open Access Review

A Review on Acupuncture as a Non-Pharmacological Treatment for Neonatal Abstinence Syndrome (NAS)

Avneet K. Mangat, Georg M. Schmölzer
Received: June 07, 2019; Published: August 20, 2019; doi:10.21926/obm.icm.1903051

Abstract: The incidence of Neonatal Abstinence Syndrome (NAS) is increasing due to more mothers using illicit drugs. This results in an increase in costs and resources for the healthcare system. Newborns with NAS might experience withdrawal symptoms that can cause pain, distress, and may potentially increase [...]

Open Access Original Research

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

Elizabeth F. Wallin, Michelle A. Linterman, Kathryn J. Wood
Received: June 02, 2019; Published: August 19, 2019; doi:10.21926/obm.transplant.1903079

Abstract: Background - T follicular helper (Tfh) and regulatory (Tfr) cells are key players in the formation of long-lived antibody responses. Their circulating counterparts, cTfh and cTfr, are often used as biomarkers because longitudinal sampling of secondary lymphoid tissues is unfeasible in clinical studi [...]

Open Access Review

Shedding Light on Manic Syndromes and Dementia

Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Claudio Lucetti, Angelo Nuti, Mario Di Fiorino
Received: March 27, 2019; Published: August 16, 2019; doi:10.21926/obm.geriatr.1903070

Abstract: Background. Mania in older adults is associated with a high rate of medical and neurological disease. Objective. The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods. Medline and Google Scholar searches were conducted for relevant artic [...]

Open Access Review

Advanced Endoscopic Techniques in the Evaluation and Treatment of Fibrostenotic Crohn's Disease

Alina Wong, Scott D Lee
Received: May 09, 2019; Published: August 16, 2019; doi:10.21926/obm.hg.1903033

Abstract: Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring [...]

Open Access Research Article

BSA-Embedded Carbonate Apatite Enhances Chemotherapeutic Effect of Paclitaxel in vitro and in vivo

Tahereh Fatemian, Ezharul Hoque Chowdhury
Received: March 29, 2019; Published: August 15, 2019; doi:10.21926/obm.genet.1903090

Abstract: Among the strategies for enhanced pharmacokinetics and also pharmacodynamics of nano-formualtions is introduction of biocompatible materials to improve the capacity of the final product. With the aim to tackle drug loading and ultimate efficacy, incorporation of Bovine Serum Albumin (BSA) into carbo [...]

Open Access Review

Diagnosis and Treatment of Mitochondrial Abnormalities in Reproductive Medicine

Joep Geraedts
Received: April 8, 2019; Published: August 14, 2019; doi:10.21926/obm.genet.1903089

Abstract: Mitochondrial diseases represent the most common inborn errors of metabolism. The overwhelming majority of mitochondrial diseases (about 85 %) are caused by mutations of nuclear genes of oxidative phosphorylation. The remaining 15 % are caused by mtDNA mutations. The familial mtDNA mutations are exc [...]

Open Access Research Article

Immunoprotective Encapsulation of Micro-Organs

Assaf Assis, Lena Sapozhnikov, Sandra Camargo, Eduardo Mitrani
Received: May 07, 2019; Published: August 14, 2019; doi:10.21926/obm.transplant.1903078

Abstract: Background: Cell encapsulation technology is most likely the ultimate solution for autologous cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct, is to consider not only the nature of the capsule but also how the cells should be incorporated into [...]

Open Access Review

Conventional and Future Therapies for Crohn's Disease

Abdulmaleek Sado, Rahul Kalla, Simon Campbell
Received: May 20, 2019; Published: August 14, 2019; doi:10.21926/obm.hg.1903032

Abstract: Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications [...]

Open Access Original Research

Intranasal Insulin in Alzheimer’s Disease: A Pragmatic Account

Sara Schatz, Melvin Gonzalez Rivera
Received: March 15, 2019; Published: August 13, 2019; doi:10.21926/obm.geriatr.1903069

Abstract: Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and ear [...]

Open Access Review

The Value Given and Presupposed in Person-Centred Dementia Care

Stephen Ames
Received: April 08, 2019; Published: August 13, 2019; doi:10.21926/obm.geriatr.1903068

Abstract: Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the stand [...]

Open Access Original Research

Differential Effects of Social Network on Health in Later Life and the Moderating Role of Depression

Shira Peleg, Howard Litwin
Received: March 23, 2019; Published: August 12, 2019; doi:10.21926/obm.geriatr.1903067

Abstract: Background: We studied the differential effects of social network characteristics on limitations with activities (LWA) and quality of life (QOL) among older adults, and the moderating role of depression. Methods: Data from two consecutive waves of the Survey of Health, Aging and Retirement in Europe [...]

Open Access Review

New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Rachel Rutherford, Patrick B Allen
Received: February 25, 2019; Published: August 12, 2019; doi:10.21926/obm.hg.1903031

Abstract: Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting [...]

Open Access Review

Next-Generation Sequencing-Based Testing in Diagnostic Oncohematology: Untangling the Knots

Ilaria Scarpelli, Fabienne Marcelli, Francesca Mattioli, Jacqueline Schoumans
Received: April 1, 2019; Published: August 9, 2019; doi:10.21926/obm.genet.1903088

Abstract: With the advent of next generation sequencing (NGS), genomic profiling of tumors has gradually been introduced into the clinical setting and become a standard in cancer care. NGS allows easier, faster and cheaper sequencing and commercially available panels enable the detection of single or global [...]

Open Access Short Report

Walk with Me

Patricia Lynn Dobkin
Received: May 14, 2019; Published: August 07, 2019; doi:10.21926/obm.icm.1903050

Abstract: The author writes a genuine story using a narrative medicine writing style [1]. She relates how she applied mindfulness awareness and meditation practices to accompany her best friend, Abigail* , who struggled through stages 3 and 4 breast cancer, including its noxious treatments and upsetting side [...]

Open Access Case Report

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Garuth Chalfont, Jane Simpson, Sarah Davies, David Morris, Ruth Wilde, Leigh Willoughby, Christine Milligan
Received: April 08, 2019; Published: August 07, 2019; doi:10.21926/obm.geriatr.1903066

Abstract: The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a ‘personalised medicine’ approach challenges this view. This paper reviews the current evidence for dementia prevention utili [...]

Open Access Review

A Model for Understanding Hispanic/Latino Family Caregiving for Older Adults

Hsueh-Fen S. Kao, Maria A. Amaya
Received: May 19, 2019; Published: August 07, 2019; doi:10.21926/obm.geriatr.1903065

Abstract: Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families [...]

Open Access Original Research

Sustainability Assessment of Power Generation from an Abandoned Oil and Gas Well in Alberta, Canada

Babkir Ali
Received: May 30, 2019; Published: August 7, 2019; doi:10.21926/jept.1903002

Abstract: The main objective of this paper is to study the sustainability of power generation from an abandoned oil and gas well in the province of Alberta, Canada. Economic and environmental indicators were used for the sustainability assessment. A conceptual design for a pilot plant was developed, and the m [...]

Open Access Project Report

Evaluation of Polymer Dispersed Liquid Crystal (PDLC) for Passive Rear Projection Screen Application

H. Hakemi, O. Pinshow, D. Gal-Fuss
Received: June 24, 2019; Published: August 07, 2019; doi:10.21926/rpm.1903002

Abstract: In past years, there have been many attempts to commercialize PDLC for Rear Projection Screen (RPS) screens as an integrated part of its main application as electrically switchable films and glass products. This application is due to exceptional image quality of PDLC at wide viewing angle. However, [...]

Open Access Original Research

Mortality Risk Factors in Patients who are in Heart Transplantation Waiting List

Petr A. Fedotov, Maria A. Simonenko, Yulia V. Sazonova, Mariya A. Bortsova, Artem N. Kostomarov, Mariya Yu. Sitnikova
Received: February 01, 2019; Published: August 05, 2019; doi:10.21926/obm.transplant.1903077

Abstract: Purpose: to estimate the survival of patients in a heart transplantation waiting list (HTxWL) at V.A.Almazov NMRC from 2010 to 2017 and to define risk factors for death among these patients. Materials and methods: A single-centre retrospective study of 151 patients with advanced chronic heart failur [...]

Open Access Review

A Review of Factors Affecting the Acute Exercise-Cognition Relationship in Children and Adolescents

Ryan A. Williams, Lorna Hatch, Simon B. Cooper
Received: April 29, 2019; Published: August 2, 2019; doi:10.21926/obm.icm.1903049

Abstract: It is well documented that an acute bout of exercise has a positive effect on subsequent cognitive function in young people. However, the moderating variables (such as the exercise intensity, duration and modality; and the domain of cognitive function assessed) and mediating variables (such as the p [...]

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