Open Access Short Report

Thalassemia Intermedia Caused by a Combination of a Globin Gene Triplication with Heterozygosity for β0 Thalassemia: A Case Report

Konstantinos Manganas, Sophia Delicou, Aikaterini Xydaki, Zoi Pallantza
Received: May 19, 2019; Published: September 17, 2019; doi:10.21926/obm.genet.1903095

Abstract: Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt hemoglobin synthesis. Thalassemia intermediate is referred to a group of disorders with a less severe form of the disease when compared with thalassemia major. We present the case of a 60 year old w [...]

Open Access Review

Management of Neuropsychiatric Symptoms of Dementia: A Comprehensive Review of the Current Literature

Laura Suarez, Reem M.A. Shafi, Maria I. Lapid
Received: May 14, 2019; Published: September 16, 2019; doi:10.21926/obm.geriatr.1903074

Abstract: Purpose of Review: Dementia is a progressive and debilitating condition that affects millions of patients in the United States with an enormous impact on healthcare costs, caregivers, and society. Patients with dementia often experience dementia-related neuropsychiatric disturbances, commonly known [...]

Open Access Review

Delaying Dementia: Targeted Brain Delivery Using Lipid Cubic Phases

Joseph S. D'Arrigo
Received: August 22, 2019; Published: September 16, 2019; doi:10.21926/obm.neurobiol.1903040

Abstract: Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) n [...]

Open Access Editorial

Introduction to Genetic Screening

Johanne Traeger-Synodinos, François Rousseau
Received: September 6, 2019; Published: September 11, 2019; doi:10.21926/obm.genet.1903094

Abstract: We present here the content and articles of this special issue on genetic screening, putting them in perspective with the field and between themselves.

Open Access Review

Impact of Case Management on HIV Patients’ Linkage to Care and Their Clinical Outcome: A Systematic Review of Randomized Clinical Trials

Siavash Jafari, Mariko Vaughan, Souzan Baharlou, Pooria Ghadiri, Nazila Hassanabadi, Ashkan Nasr
Received: August 11, 2019; Published: September 09, 2019; doi:10.21926/obm.neurobiol.1903039

Abstract: Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed [...]

Open Access Original Research

Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients over Age 55: A Multiple Case Study Report

Randolph James, Amy Lawson Moore, Dick M Carpenter II, Terissa Michele Miller, Christina Ledbetter
Received: April 29, 2019; Published: September 06, 2019; doi:10.21926/obm.icm.1903054

Abstract: (1) Background: The current study examined a multifaceted anti-neuroinflammatory intervention that included physical exercise, mental exercise, grain-free/sugar-free diet, anti-inflammatory nutritional supplements, sleep optimization, and stress management within the context of a functional medicine [...]

Open Access Review

Newborn Screening for Genetic Diseases: An Overview of Current and Future Applications

Damien Bouvier, Yves Giguère
Received: July 1, 2019; Published: September 6, 2019; doi:10.21926/obm.genet.1903093

Abstract: Newborn screening (NBS) for inborn errors of metabolism (IEM) was introduced more than 50 years ago with the testing of phenylketonuria (PKU) using blood spots deposited on a filter paper after heel prick. NBS aims to identify early after birth inherited disorders for which clinical management and p [...]

Open Access Communication

Upregulation of COX-2 in MCF7 Breast Cancer Cells When Exposed to Shear Stress

Caymen M. Novak, Eric N. Horst, Shreya Raghavan, Geeta Mehta
Received: June 17, 2019; Published: September 6, 2019; doi:10.21926/obm.genet.1903092

Abstract: Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, metastasis, and has [...]

Open Access Review

Infectious Considerations for Patients on Immune Checkpoint Inhibitors

Anita Modi, Sherif Beniameen Mossad
Received: July 07, 2019; Published: September 06, 2019; doi:10.21926/obm.transplant.1903085

Abstract: Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of m [...]

Open Access Original Research

The Viterbo Hydrothermal System and Its Sustainable Exploitation, Central Italy

Ugo Chiocchini, Giovanni Savarese
Received: May 14, 2019; Published: September 05, 2019; doi:10.21926/jept.1903003

Abstract: Background. The Regione Lazio - Direzione Regionale dello Sviluppo Economico e delle Attività Produttive (RL – DRSEAP), carrying out its public functions to govern the use of mineral resources including thermal water, planned the exploitation of the Viterbo hydrothermal system on the basis of a conc [...]

Open Access Review

Benefits of Combined Liver Transplant: Protection or Tolerance?

Salim Hamdani, Daniel Azoulay
Received: April 18, 2019; Published: September 04, 2019; doi:10.21926/obm.transplant.1903084

Abstract: The privileged liver by its immunological status is described as a tolerogenic organ. However, these alone do not explain the installation of a tolerance after single or combined liver transplantation (kidney, heart, pancreas, intestine). Other factors appear to be involved in the identification of [...]

Open Access Review

Super-Resolution of Nano-Materials and Quantum Effects Obtained by Microspheres

Y. Ben-Aryeh
Received: July 29, 2019; Published: September 04, 2019; doi:10.21926/rpm.1903003

Abstract: Microsphere super-resolutions, which are beyond the Abbe classical limit, are described. The conversion of evanescent waves to propagating waves, are analyzed by using the geometry of the microsphere. In microsphere experiments a nanojet is produced near the focal plane where its width is smaller th [...]

Open Access Original Research

Assessing the Pressure and Thermal Discomfort Thresholds for Designing of Therapeutic Gloves: A Pilot Study

Siti Hana Nasir, Olga Troynikov, Dawn Wong Lit Wan, Zhen Zheng

Received: February 25, 2019; Published: September 02, 2019; doi:10.21926/obm.icm.1903053

Abstract: Background: Pressure and thermal therapy glove are the two types of therapeutic gloves that are commonly used to relieve symptoms and improve hand function in patients with hand arthritis. However, no published clinical studies exist indicating the ideal pressure and thermal stimuli for the gloves. [...]

Open Access Case Report

Secondary Acute Pancreatitis Associated with Paracetamol and Codeine Administration after Dental Treatment: Literature Analysis and Clinical Case Study

Alessandro Luigi Rossi, Vincenzo Capilupi, David Palombo, Luigi Tagliatesta, Tecla Terenzio, Marco Vitali, Matteo Chiapasco
Received: April 29, 2019; Published: August 30, 2019; doi:10.21926/obm.hg.1903035

Abstract: OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS A [...]

Open Access Research Article

Characterization of Early Indicators of Cardiac Allograft Vasculopathy Lesions in a Rat Model Using Non-Invasive Cellular MR

Qing Ye, Yijen L. Wu, Lesley M. Foley, Parker H. Mills, Fang-Cheng Yeh, Haosen Zhang, Danielle F. Eytan, Li Liu, T. Kevin Hitchens, Chien Ho
Received: January 07, 2019; Published: August 29, 2019; doi:10.21926/obm.transplant.1903083

Abstract: Background: Cardiac allograft vasculopathy (CAV) remains a major obstacle to long-term heart allograft survival. A number of studies show that immune mechanisms involved in CAV. Using non-invasive cellular MRI (CMRI) to explore indicators of CAV lesions and characterize its development could provi [...]

Open Access Review

Hyperglycemia-Induced Brain Injury in Preterm Infants

Katherine Satrom, Tate Gisslen, Raghavendra Rao
Received: May 29, 2019; Published: August 29, 2019; doi:10.21926/obm.neurobiol.1903038

Abstract: Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...]

Open Access Review

Rare Causes of Acute Pancreatitis: Drugs, Eosinophilia, and Autoimmunity

Mauro Turrin
Received: March 15, 2019; Published: August 29, 2019; doi:10.21926/obm.hg.1903034

Abstract: Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February [...]

Open Access Review

Does a Single Bout of Aerobic Exercise Improve Set Shifting in Healthy Young Adults? A Systematic Review and Meta-Analysis

Max Oberste, Sophia Sharma, Philipp Zimmer
Received: April 24, 2019; Published: August 28, 2019; doi:10.21926/obm.icm.1903052

Abstract: This systematic review investigated whether acute aerobic exercise improves following set-shifting performance in healthy young individuals using meta-analytic techniques. Moreover, it was examined if the after-effect of acute aerobic exercise on set-shifting performance in healthy young adults is m [...]

Open Access Short Report

Estradiol 17-β Induces Pancreatic Beta-Cell Proliferation through Distinct Estrogen Receptors in a Glucose Dependent Manner

Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Gaby Shefer, Dalia Somjen, Naftali Stern
Received: April 17, 2019; Published: August 27, 2019; doi:10.21926/obm.transplant.1903082

Abstract: Background: Estradiol 17-beta (E2) enhances the function and survival of pancreatic beta-cells but its clinical use has been questioned due to concerns regarding oncogenic potential and feminizing effects in males. The G-protein coupled estrogen receptor (GPER), expressed in pancreatic islets, exhib [...]

Open Access Review

Viral Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Literature Review

Shruthi Kodad, Waleed Sabry, Assem Elsayed, Hadi Goubran, Mohamed Elemary
Received: June 25, 2019; Published: August 26, 2019; doi:10.21926/obm.transplant.1903081

Abstract: Hematopoietic stem cell transplant (HSCT) recipients are at an increased risk of bacterial, viral, fungal and parasitic infections. Past exposures to infections, the degree of immunosuppression, prolonged neutropenia and presence of graft versus host disease (GVHD) are some of the factors which make [...]

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