Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Abstract: In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the on [...]

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Omid Ranjbar Pouya, Ahmad Byagowi, Debbie M. Kelly, Zahra Moussavi
Received: August 20, 2018; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902059

Abstract: Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) [...]

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Niklas Gudowsky, Ulrike Bechtold, Leo Capari, Mahshid Sotoudeh
Received: January 31, 2019; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902058

Abstract: (1) Background: In the light of recent changes in the discourse on positive ageing approaches, we take a closer look at the way “quality ageing” is understood, expressed and dealt with in technology assessment (TA) that investigates desirable frameworks and futures for an ageing society from a citiz [...]

Open Access Review

Sleep and Help Seeking Behaviours in Australia: A Narrative Review

Kelly P Attard, Robert JT Adams, Andrew Vakulin, Amy C Reynolds
Received: March 22, 2019; Published: June 27, 2019; doi:10.21926/obm.neurobiol.1902029

Abstract: Inadequate sleep is a largely under recognised problem in Australian communities despite researchers consistently highlighting it as a key component of health and wellbeing. Over a third of Australian adults now experience some form of inadequate sleep, which is strongly linked to a range of accompa [...]

Open Access Original Research

Individual Radiosensitivity in Lung Cancer Patients Assessed by G0 and Three Color Fluorescence in Situ Hybridization

Theresa Mayo, Barbara Schuster, Anna Ellmann, Manfred Schmidt, Rainer Fietkau, Luitpold V. Distel
Received: July 27, 2018; Published: June 26, 2019; doi:10.21926/obm.genet.1902082

Abstract: Background: It is known that radiosensitivity is very individual. This can influence the tumor response and side effects in normal tissue after radiotherapy of cancer. Therefore we analyzed the sensitivity of a lung cancer cohort to see if they display a similar radiosensitivity distribution if comp [...]

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active Glp-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Abstract: Background One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality  cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have [...]

Open Access Original Research

Experimental Effects of Acute Exercise in Attenuating Concurrent Memory Interference

Hannah Lewandowski, Lindsay Crawford, Paul D. Loprinzi
Received: April 13, 2019; Published: June 25, 2019; doi:10.21926/obm.icm.1902039

Abstract: Acute exercise may enhance episodic memory recall, or the retrospective recall of an event or episode due to exercise-induced neuronal excitability and ensuing long-term potentiation. Of interest to this paper is the potential effects of acute exercise on memory interference, when the interfering st [...]

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Abstract: The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understand [...]

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Richell Booijink, Ruchi Bansal
Received: March 27, 2019; Published: June 21, 2019; doi:10.21926/obm.hg.1902024

Abstract: Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of [...]

Open Access Research Article

Preliminary Long-Term Results of Homeopathic Treatment of Atopic Diseases in Adult Patients

Elio Rossi, Marco Picchi, Marialessandra Panozzo, Linda Nurra
Received: November 01, 2018; Published: June 20, 2019; doi:10.21926/obm.icm.1902038

Abstract: Aim: To study the effect of homeopathic treatment on adult patients with atopic diseases visited at the Homeopathic Clinic of Lucca (Italy) and long-term evolution of the disease over approximately an 8-year period. Materials and Methods: Data derive from an observational longitudinal study carried [...]

Open Access Case Report

A De Novo Childhood Case of T-cell Lymphoblastic Leukemia with High Hyperdiploid Karyotype Carrying an Unreported Balanced Translocation t(X;5)(q26;q31.3~32) in A Male Patient

Walid AL-ACHKAR, Manar As’sad, Thomas Liehr, Adnan Ikhtiar, Abdulsamad Wafa
Received: August 14, 2018; Published: June 20, 2019; doi:10.21926/obm.genet.1902081

Abstract: (1) Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes with multiple genetic abnormalities, accounting for 15% and 25% of newly diagnosed cases of ALL in children and adults, respectively. Notably, T-ALL has a 3-fold higher incidence in males. Cytogenet [...]

Open Access Opinion

Doing Brief Work, Slowly: Compassion as Intervention in Behavioral Medicine

Ron Dolgin, Matthew J. Davis
Received: March 20, 2019; Published: June 18, 2019; doi:10.21926/obm.icm.1902037

Abstract: Integration of behavioral health consultants and specialists into medical settings has accelerated the development of evidenced-based practices for an array of problems and concerns common to behavioral medicine. Though these treatments have shown to be beneficial for those that engage in protocols, [...]

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Joseph S. D'Arrigo
Received: December 27, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902057

Abstract: Much evidence has been reported which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorpor [...]

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Michael Chapman, Jennifer Philip, Paul Komesaroff
Received: December 20, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902056

Abstract: Alzheimer’s Disease is increasingly seen as the major health in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The perva [...]

Open Access Perspective

Compassion in Preregistration Nurse Education: An Integrated Review

Pras Ramluggun, Sanj Nathoo
Received: March 07, 2019; Published: June 13, 2019; doi:10.21926/obm.icm.1902036

Abstract: The evolving, dynamic and challenging healthcare landscape requires that the art and science of nursing equip preregistration nursing students (PNS) with the knowledge and skills to positively respond to these changes. Central to PNS’ ability to demonstrate competence in the fundamentals of nursing [...]

Open Access Review

Zinc in Liver Fibrosis

Kurt Grüngreiff , Thomas Gottstein, Dirk Reinhold
Received: March 15, 2019; Published: June 13, 2019; doi:10.21926/obm.hg.1902023

Abstract: Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connect [...]

Open Access Case Report

Cancer and the Display of Lymph Nodes Using Potentized Remedies (Derivates of Iodine and Carbo Animalis)

Dietmar Payrhuber, Piero Sangaletti, Josef Muehlmann
Received: May 10, 2018; Published: June 10, 2019; doi:10.21926/obm.icm.1902035

Abstract: (1) Background: The article provides insight into the mode of the immune system acting hierarchically when administering potentized remedies. Occasionally, this can be best seen in severe cases as available with cancer. (2) Methods: The careful anamnesis and subsequent prescription is based on Jan S [...]

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

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