Cancer Genetics and Epigenetics Alterations
Submission Deadline: September 30, 2019 (Open) Submit Now
Lunawati Bennett MS, PhD, PharmD, FACN Professor of Pharmaceutical Sciences, Union University College of Pharmacy, Jackson, Tennessee
Email: [email protected]
Research interests: role of antioxidants and nutraceuticals in cancer, pharmacogenomics, treatment of rare diseases, cancer genetics, leukemia, breast cancer, colorectal cancer, lung cancer, and brain cancer
About This Topic
Upcoming insight into understanding cancer genetics and epigenetic aberration of different type of cancers. Cancer is heterogeneous disease arise from defects in the structures of cells, aberration of genes, or alteration in key cellular pathways that regulate proliferation, differentiation, and apoptosis of normal cells. The mutations in cancer are usually due to gain-of-function of proto-oncogenes becomes oncogenes and/or loss function of tumor suppressor genes. Epigenetic mechanism also plays critical role in altering the patterns and levels of protein expression of certain genes, chromatin modifying protein, DNA methylation and patterns of gene expression in cancer cells. Although diverse mutations and gene expression changes have been implicated in cancer pathogenesis, the defects appear to limited number of gene alterations such as RAS, EGFR, PTEN, p53, Akt, PTEN and others; however, the accumulated multiple genetics and epigenetics defects play fundamental role in cancer initiation and progression.
This issue primary aims is to understand how persons genetics, chemical carcinogenesis, environment, gut microbes, dietary factors, and epigenetic alterations play important role in cancer initiation and progression.
Keywords: genetic defects; cancer alter signaling pathways; genomic integrity, oncogene mutations; tumor suppressor; proto oncogene; epigenetic alterations; chromatin regulator; histone hyper-methylation; histone hypo-methylation
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