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Special Issue

Pneumocystis: A Model of Adaptive Coevolution

Submission Deadline: October 31, 2018 (Open)               Submit Now

Guest Editors

Andrés Moya
Prof. of Genetics, Institute of Integrative Systems Biology (University of Valencia), FISABIO Foundation for Biomedical Research and CIBER in Epidemiology and Public Health (CIBERESP), Spain
E-Mail: [email protected]
Research Interests: genome evolution, symbiosis, microbiome

Enrique J. Calderón
Associate Prof. of Medicine, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain
E-Mail: [email protected]
Research Interests: Infectious diseases, Pneumcystosis

Luis Delaye
Prof. of Bioinformatics, CINVESTAV Irapuato, México
E-Mail: [email protected]
Research Interests: molecular evolution, phylogenetic inference

About This Topic

Pneumocystis organisms, which were first reported and named Pneumocystis carinii at the beginning of the last century, were long considered as protozoans and a single species based on morphologic features and the resistance to classical antifungal agents. The lack of a continuous in vitro system was a major obstacle to Pneumocystis research and these organisms were largely ignored until the dramatic increase in the incidence of Pneumocystis pneumonia that occurred with the emergence of the human immunodeficiency virus (HIV) pandemic, which made pneumocystosis a major medical and public health problem in the 1980s. However, this obvious pathogenic Pneumocystis–host interaction is only the tip of the iceberg, and recent findings suggest that the vast majority of mammal–Pneumocystis interactions led to relatively benign colonization, rather than pneumonia.

Molecular and biochemical studies have provided clear evidence for the placement of Pneumocystis with fungi, and based on genomic or phenotypic divergence, multiple Pneumocystis species have been recognized. Genetic data, in addition, suggested that speciation in the group resulted from long genetic isolation and co-evolution in parallel with mammal species.

In this special issue of OBM Genetics, we present the state-of-the art of the genetics and the coevolution of Pneumocystis in different mammalian species in a broad perspective, although with a particular emphasis on the human host. Reviews and methodological papers related with the topic are also welcome.

Planned Papers

Title: Dihydropteroate synthase (DHPS) polymorphisms in Pneumocystis jirovecii
Authors: Carmen de la Horra, Vicente Friaza, Rubén Morilla, María Mercedes Panizo, Yaxsier de Armas, Gustavo Wissmann, Enrique J. Calderón



Airborne Interindividual Transmission of Pneumocystis jirovecii

Laurence Pougnet, Solène Le Gal, Gilles Nevez
Received: December 17, 2018; Published: May 22, 2019; doi:10.21926/obm.genet.1902080


Pneumocystis Species Co-evolution: State-of-the-Art Review

Christine Demanche, Jacques Guillot, Magali Chabé
Received: February 22, 2019; Published: May 15, 2019; doi:10.21926/obm.genet.1902078

Research Article

New DNA Extraction Method for the Detection of Pneumocystis in Lung Tissue Samples of Colonized Individuals

Susana Ruiz-Ruiz, Carolina A Ponce, Nicole Pesantes, Rebeca Bustamante, Gianna Gatti, Viviana San Martin, Mireya Gutierrez, Mariana Izquierdo, Sergio L Vargas, Fabien Magne, Vicente Pérez-Brocal
Received: January 30, 2019; Published: March 18, 2019; doi:10.21926/obm.genet.1901066


Genotyping Pneumocystis jirovecii: Impacting Our Understanding of Interhuman Transmission

Maud Gits-Muselli, Stéphane Bretagne, Alexandre Alanio
Received: December 4, 2018; Published: January 18, 2019; doi:10.21926/obm.genet.1901060


Pneumocystis as a Co-Factor in Pulmonary Diseases

Whitney Rabacal, Emily Rayens, Karen Norris
Received: November 2, 2018; Published: December 27, 2018; doi:10.21926/obm.genet.1804057


Reminiscence from Half a Century of Anti-Pneumocystis Drug Discovery and Development

Walter Hughes
Received: September 12, 2018; Published: December 5, 2018; doi:10.21926/obm.genet.1804052


Pneumocystis jirovecii Pneumonia: Current Advances in Laboratory Diagnosis

Ana Luísa Tomás, Olga Matos
Received: August 21, 2018; Published: November 13, 2018; doi:10.21926/obm.genet.1804049


The Relationship between Pneumocystis Infection in Animal and Human Hosts, and Climatological and Environmental Air Pollution Factors: A Systematic Review

Robert F. Miller, Laurence Huang, Peter D. Walzer
Received: September 14, 2018; Published: October 26, 2018; doi:10.21926/obm.genet.1804045