OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
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Rapid publication: manuscripts are undertaken in 8.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).
Pneumocystis: A Model of Adaptive Coevolution
Submission Deadline: October 31, 2018 (Open) Submit Now
Prof. of Genetics, Institute of Integrative Systems Biology (University of Valencia), FISABIO Foundation for Biomedical Research and CIBER in Epidemiology and Public Health (CIBERESP), Spain
Research Interests: genome evolution, symbiosis, microbiome
Associate Prof. of Medicine, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain
Research Interests: Infectious diseases, Pneumcystosis
Prof. of Bioinformatics, CINVESTAV Irapuato, México
Research Interests: molecular evolution, phylogenetic inference
About This Topic
Pneumocystis organisms, which were first reported and named Pneumocystis carinii at the beginning of the last century, were long considered as protozoans and a single species based on morphologic features and the resistance to classical antifungal agents. The lack of a continuous in vitro system was a major obstacle to Pneumocystis research and these organisms were largely ignored until the dramatic increase in the incidence of Pneumocystis pneumonia that occurred with the emergence of the human immunodeficiency virus (HIV) pandemic, which made pneumocystosis a major medical and public health problem in the 1980s. However, this obvious pathogenic Pneumocystis–host interaction is only the tip of the iceberg, and recent findings suggest that the vast majority of mammal–Pneumocystis interactions led to relatively benign colonization, rather than pneumonia.
Molecular and biochemical studies have provided clear evidence for the placement of Pneumocystis with fungi, and based on genomic or phenotypic divergence, multiple Pneumocystis species have been recognized. Genetic data, in addition, suggested that speciation in the group resulted from long genetic isolation and co-evolution in parallel with mammal species.
In this special issue of OBM Genetics, we present the state-of-the art of the genetics and the coevolution of Pneumocystis in different mammalian species in a broad perspective, although with a particular emphasis on the human host. Reviews and methodological papers related with the topic are also welcome.
Title: Dihydropteroate synthase (DHPS) polymorphisms in Pneumocystis jirovecii
Authors: Carmen de la Horra, Vicente Friaza, Rubén Morilla, María Mercedes Panizo, Yaxsier de Armas, Gustavo Wissmann, Enrique J. Calderón
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