Third Generation Sequencing
Submission Deadline: January 31, 2019 (Open) Submit Now
Milan Macek Jr., MD, DSc
Professor of Medical and Molecular Genetics, Chairman of Department of Biology and Medical Genetics, Chairman of the National Coordination Centre for Rare Diseases, University Hospital Motol and 2nd Faculty of Medicine, Charles University Prague, V Uvalu 84, Praha 5, CZ 150 06, Czech Republic
E-Mail: [email protected]
Research Interests: molecular genetics; human genetics; medical genomics; reproductive genetics; rare diseases; cystic fibrosis; health economics
Third generation sequencing (also known as long-read sequencing, TGS) is a class of DNA sequencing methods, which is creating a renaissance in high-quality genome sequencing. By enabling direct sequencing of single DNA molecules, TGS has the capability to produce substantially longer reads, in contrast to second generation sequencing, which produces short reads a few hundred base-pairs long. TGS, as it currently stands, faces important challenges mainly surrounding accurate identification of nucleotide bases which lead to higher error rates than second generation sequencing, rendering the technologies impractical for certain applications such as de novo genome assembly. These technologies are undergoing active development and therefore it is expected that there will be further improvements to reduce the high error rates. For applications that are more tolerant to error rates, TGS has been found to outperform existing methods.
In this special issue of OBM Genetics, we aim to the introduction of current technologies, application as well as many challenges and limitations TGS faces. We accept original research papers, reviews, editorial, short communications, case reports and perspectives on TGS. We sincerely welcome authors in this field to contribute their excellent works to this exciting forum.
Manuscripts should be submitted online at http://www.lidsen.com/account-login by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. Guidelines for authors and other relevant information for submission of manuscripts are available on the Instructions for Authors page. OBM Genetics is an international peer-reviewed Open Access monthly journal published by LIDSEN. Please visit the Instructions for Authors page before submitting a manuscript.