OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
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Behavioral Symptoms of Dementia
Submission Deadline: July 30, 2019 (Open) Submit Now
Ladislav Volicer, MD, PhD
Courtesy Full Professor, School of Aging Studies, College of Arts and Sciences, University of South Florida, Tampa, FL, 33620, USA
External Professor, 3rd Medical Faculty, Charles University, Prague, Czech Republic
Research Interests: Dementia; Alzheimer's disease; Palliative care; Medical ethics; Behavioral symptoms of dementia
About This Topic
Behavioral symptoms in persons with progressive degenerative dementias are often more disabling and more difficult to manage than cognitive impairments. Therefore, there is a need for more information about this topic and the planned special issue will provide it. It is important to differentiate between two main syndromes: agitation and rejection of care. Agitation often happens when the person with dementia is solitary and not interacting with other people. Rejection of care happens during care activities when the person with dementia does not recognize the intent of the care provider and the need for care. If the care provider insists on providing care, the person with dementia defends himself/herself from unwanted attention and may become combative. The person may then be labeled as assaultive or aggressive, while he/she perceives the care provider as an aggressor. The distinction between agitation and rejection of care/aggression is important because different non-pharmacological strategies are needed for managing these behavioral symptoms. Agitation is often caused by boredom and can be prevented by provision of meaningful activities. Aggression is best managed by improved communication and by modification of care strategies. There is disagreement among the experts if aggression should be considered part of agitation. I am sure that the special issue will provide different points of view that will address this controversy.
Renate Verkaik, Iris van der Heide, Eugenie van Eerden, Peter Spreeuwenberg, Erik Scherder, Anneke L. Francke
Received: April 02, 2019; Published: December 11, 2019; doi:10.21926/obm.geriatr.1904092
Laura Suarez, Reem M.A. Shafi, Maria I. Lapid
Received: May 14, 2019; Published: September 16, 2019; doi:10.21926/obm.geriatr.1903074
Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Claudio Lucetti, Angelo Nuti, Mario Di Fiorino
Received: March 27, 2019; Published: August 16, 2019; doi:10.21926/obm.geriatr.1903070
Mario D. Garrett
Received: June 12, 2019; Published: July 16, 2019; doi:10.21926/obm.geriatr.1903063
Received: November 04, 2018; Published: November 8, 2018; doi:10.21926/obm.geriatr.1804019