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Special Issue

Perspectives on Telomeres and Aging

Submission Deadline: January 31, 2019 (Open)                Submit Now

Guest Editor

Michael Fossel, MD, PhD
1. President of Telocyte (http://www.telocyte.com), Grand Rapids, MI 49503, USA
2. Retired Clinical Professor of Medicine, Michigan State University, Ada, MI 49301, USA
E-Mails: [email protected]; [email protected]
Website: http://www.michaelfossel.com
Research Interests: human aging; telomeres; telomerase therapy; age-related diseases; Alzheimer's disease

About This Topic

Geriatrics aims to treat the diseases of older human beings, an aim that we have consistently failed to achieve with any great efficacy. Yet both theory and growing experimental data suggest that this is about to change significantly, largely due to an increased understanding of the role played by changes in gene expression in senescent cells that result in aging disease. This is not merely a conceptual revolution, but has practical, clinical implications: we have the nascent ability to treat disease by extending telomeres and thereby resetting gene expression. The experimental results in animal studies have been remarkable and FDA human trials are planned.
Beyond the few interventional trials with telomerase activators and the planned human trials with telomerase gene therapy, there is also a growing literature on the relationship between telomere lengths and aging and, more importantly, age-related disease.
Geriatrics will publish a special issue on the relationship between telomeres and aging. We encourage submission of research on the role of telomeres (and telomerase) in geriatric medicine, to specifically include articles giving a perspective on the diagnostic and therapeutic potential of telomeres and aging.

Planned Papers

Title: Telomeres in Aging, Development, and Longevity
Author: Alvaro Macieira-Coelho

Title: Telomere, stress, stress-related mental disorders and aging
Author: Lei Zhang

Title: Telomeres and Heart failure in Aging patients
Author: Bodh I. Jugdutt
Affiliation: 2C2 W.C. Mackenzie Health Sciences Centre, Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, 8440-112 Street, Edmonton, Alberta, Canada

Title: Telomeres, diet and ageing: what is the evidence for a link?
Authors: Anastasia Z. Kalea 1, Jessica L. Buxton 2
Affiliations:
1. UCL Division of Medicine, Rayne Building, 5 University St, London WC1E 6JF, UK;
2. School of Life Sciences, Pharmacy and Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK

Title: Biological Age versus Chronological Age in the Prevention of Age Associated Diseases
Authors: Gian Andrea Rollandi 1, *, Aldo Chiesa 1, Nicoletta Sacchi 1, Matteo Puntoni 1, Adriana Amaro 2, Ulrich Pfeffer 2, *
Affiliations:
1. Ente Ospedaliera Galliera, Genova, Italy;
2. IRCCS Ospedale Policlinico San Martino, Genova, Italy;

Title: Telomeres in Aging, Development, and Longevity
Author: Alvaro Macieira-Coelho
Abstract:
It has been postulated that telomere shortening is a main cause of cell proliferative senescence and of organism aging. This statement is based on the following propositions: The number of divisions of cells in vitro is inversely related with telomere length and with the age of the donor, hence telomere length is inversely related with age of the organism. The propositions, however, have not been ascertained. Indirect and circumstantial evidences suggest that some developmental events are regulated at the level of telomeres. Telomeres also seem to influence positively or negatively species longevity depending upon their role on chromosomal recombination, which can confer genetic stability or instability.

Title: Cross-talk between Genetic Modulators of Human Longevity & Telomeres
Authors: Trevor Torigoe, Bradley Willcox, Craig Willcox, Michio Shimabukuro, Richard Allsopp

Publication

Review

Cell Senescence, Telomerase, and Senolytic Therapy

Michael Fossel
Received: December 31, 2018; Published: February 15, 2019; doi:10.21926/obm.geriatr.1901034

Editorial

Telomere Editorial - Perspectives on Telomeres and Aging

Michael Fossel
Received: January 29, 2019; Published: January 31, 2019; doi:10.21926/obm.geriatr.1901031