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Special Issue

Biomarkers in Transplantation

Submission Deadline: November 30, 2018 (Open)               Submit Now

Guest Editor

Mazhar A. Kanak, PhD
Assistant Professor, Transplant Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
E-Mail: [email protected]
Website: https://surgery.vcu.edu/specialties/transplant/kanak.html
Research Interests: Inflammation in islet transplantation; Nuclear Factor Kappa B (NFkB) regulation in inflammatory response; Mechanism of islet rejection; Diabetes Type 1 and 2 development; Biomarkers in transplantation; Tolerance induction; Novel immunosuppression for transplantation; Strategies to improve islet transplantation

About This Topic

Transplantation of organs, tissues, and cells as a cure for life threatening diseases is being performed for several decades now. The major challenge is to keep the graft healthy and alive for the lifetime of the patient. The use of immunosuppression has somewhat favored survival of graft but only temporarily. Detection and management of graft failure early enough to intervene the process of rejection has been widely sought. Biomarkers are molecular, biochemical, or morphological profiles or observations that can be used to monitor graft function, graft loss (acute/chronic), antibody mediated rejection, immune status of the patients etc. Several sources of biomarkers have been explored including protein signatures, mRNA expression, miRNA profiles, cell-free DNA and exosomal analysis. Technological advancement has enabled significant progress towards the development of novel biomarkers. Biomarkers in transplantation can be used to monitor immunosuppression profile, reduce morbidity, improve long-term graft survival and life-expectancy of the patient.

The scope of this special issue will be to introduce the role of biomarkers in transplantation, discuss the biomarkers currently in clinical practice in various forms of transplantation, and demonstrate the use of new technologies and research involved in the development of biomarkers. This special issue is open to all authors involved in the study and development of biomarkers in the area of clinical transplantation.

Planned Papers

Title: Alpha-1-Glycoprotein may be a Novel Biomarker of Frailty in Cirrhosis
Authors: Laura A. Huppert, MD, Marie Sinclair MD, and Jennifer Lai, MD

Publication

Research Article

Aspiration of Gastrointestinal Material and Induction of Fibronectin Expression in Lung Transplant Recipients: Implications for Early Airway Remodeling

Jill Gualdoni, Jeff Ritzenthaler, Ibrahim Elkhawas, Gerene Bauldoff, David Nunley, Jesse Roman
Received: November 29, 2018; Published: February 20, 2019; doi:10.21926/obm.transplant.1901051

Research Article

Identifying Novel Biomarkers of Frailty in Cirrhosis: Results from an Unbiased Proteomics Search from the Functional Assessment in Liver Transplantation (FrAILT) Study

Laura A. Huppert, Marie Sinclair, Jennifer C. Lai
Received: November 08, 2018; Published: November 28, 2018; doi:10.21926/obm.transplant.1804028

Original Research

MicroRNAs as Potential Markers for Advantageous Perfusion in a Preclinical Donation after Cardiac Death Animal Model of Oxygenated Hypothermic Machine Perfusion (HOPE)

Victoria Gómez-Dos-Santos, Vital Hevia-Palacios, Edurne Ramos-Muñoz, María Laura García-Bermejo, Esperanza Macarena Rodríguez-Serrano, Ana Saiz-González, José Manuel Del Rey-Sánchez, Francisco Javier Burgos-Revilla
Received: March 21, 2018; Published: June 12, 2018; doi:10.21926/obm.transplant.1802012