OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Biomarkers in Transplantation
Submission Deadline: November 30, 2018 (Open)
Mazhar A. Kanak, PhD
Assistant Professor, Transplant Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
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Research Interests: Inflammation in islet transplantation; Nuclear Factor Kappa B (NFkB) regulation in inflammatory response; Mechanism of islet rejection; Diabetes Type 1 and 2 development; Biomarkers in transplantation; Tolerance induction; Novel immunosuppression for transplantation; Strategies to improve islet transplantation
About This Topic
Transplantation of organs, tissues, and cells as a cure for life threatening diseases is being performed for several decades now. The major challenge is to keep the graft healthy and alive for the lifetime of the patient. The use of immunosuppression has somewhat favored survival of graft but only temporarily. Detection and management of graft failure early enough to intervene the process of rejection has been widely sought. Biomarkers are molecular, biochemical, or morphological profiles or observations that can be used to monitor graft function, graft loss (acute/chronic), antibody mediated rejection, immune status of the patients etc. Several sources of biomarkers have been explored including protein signatures, mRNA expression, miRNA profiles, cell-free DNA and exosomal analysis. Technological advancement has enabled significant progress towards the development of novel biomarkers. Biomarkers in transplantation can be used to monitor immunosuppression profile, reduce morbidity, improve long-term graft survival and life-expectancy of the patient.
The scope of this special issue will be to introduce the role of biomarkers in transplantation, discuss the biomarkers currently in clinical practice in various forms of transplantation, and demonstrate the use of new technologies and research involved in the development of biomarkers. This special issue is open to all authors involved in the study and development of biomarkers in the area of clinical transplantation.
Jill Gualdoni, Jeff Ritzenthaler, Ibrahim Elkhawas, Gerene Bauldoff, David Nunley, Jesse Roman
Received: November 29, 2018; Published: February 20, 2019; doi:10.21926/obm.transplant.1901051
Laura A. Huppert, Marie Sinclair, Jennifer C. Lai
Received: November 08, 2018; Published: November 28, 2018; doi:10.21926/obm.transplant.1804028
Victoria Gómez-Dos-Santos, Vital Hevia-Palacios, Edurne Ramos-Muñoz, María Laura García-Bermejo, Esperanza Macarena Rodríguez-Serrano, Ana Saiz-González, José Manuel Del Rey-Sánchez, Francisco Javier Burgos-Revilla
Received: March 21, 2018; Published: June 12, 2018; doi:10.21926/obm.transplant.1802012