Special Issue

Multiple Aspects of Transplant Tolerance – Mechanisms, Strategies, and Barriers

Submission Deadline: September 30, 2018 (Closed)

Guest Editor

Jean Kwun, PhD

Assistant Professor of Surgery, Duke Transplant Center, Department of Surgery, Duke University Medical Center, 207 Research Dr, Jones 362, Durham, NC 27710, USA

Website | E-Mail

Research Interests: heart transplantation, transplant tolerance, humoral tolerance to organ transplants, mechanisms of antibody-mediated rejection (AMR), establishing a conceptual basis that will translate into therapeutic intervention of AMR

About This Topic

The idea of immunological tolerance was developed from seminal works by Ray Owen, Sir F. MacFarlane Burnet, and Sir Peter Medawar in the mid-20th century. These findings drove transplantation research to identify mechanisms of immune tolerance. However, despite partial success, it was unable to stably induce tolerance in immunocompetent recipients. In the special issue, “Multiple Aspects of Transplant Tolerance”, we will provide a forum for presenting mechanisms, strategies, and challenges for promoting tolerance in transplantation. This will include description of cell populations plays a crucial role in tolerance as well as cell-based approaches (Treg, Mreg, DCreg, CD8 Treg, Tr1, and not excluding BM, apoptotic cell-based strategies), identification/validation of clinical tolerance strategy and biomarkers. Finally, we will also cover B cell immunobiology in transplantation and strategies for B cell and plasma cell tolerance. The special issue will also be open to any author, but mainly invited by guest editor. Each submission will be reviewed by at least two reviewers to ensure a very high quality of papers selected for the Special Issue.

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (transplantation@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!

Publication

Open Access Review Antibody-Based Preparative Regimens for Cell, Tissue and Organ Transplantation by Maïté Van Hentenryck  , Zhanzhuo Li  , Philip M. Murphy  and Agnieszka Czechowicz Received: 24 November 2021;  Published: 08 July 2022;  doi: 10.21926/obm.transplant.2203162 Abstract The ability to successfully transplant cells and organs from a donor into an immunologically disparate recipient is one of the greatest treatment advances in the history of medicine. Nevertheless, acute and chronic rejection, graft versus host disease, and the inability to identify suitable donors continue to be challenges and limit broader [...]

Open Access Review Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance by Victoria Rendell  , Natalie M. Bath  and Todd V. Brennan Received: 09 May 2019;  Published: 10 March 2020;  doi: 10.21926/obm.transplant.2001104 Abstract Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize “for the discovery of acquired immunologic tolerance” and eventually made organ transplantation a reality. However, at the time of his earl [...]

Open Access Review Benefits of Combined Liver Transplant: Protection or Tolerance? by Salim Hamdani  and Daniel Azoulay Received: 18 April 2019;  Published: 04 September 2019;  doi: 10.21926/obm.transplant.1903084 Abstract The privileged liver, due to its immunological status, is referred to as a tolerogenic organ. However, this alone does not explain the introduction of tolerance after single or combined liver transplantation (kidney, heart, pancreas, and intestine); other factors, such as recipient’s age, donor’s hepatic volume, iron metabolism, biomarkers [...]

Open Access Review Induction of Tolerance towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models by Scott S. Graves  , DavidW. Mathes  and Rainer Storb Received: 23 November 2018;  Published: 23 August 2019;  doi: 10.21926/obm.transplant.1903080 Abstract Background: The application of hematopoietic cell transplantation for induction of immune tolerance has been limited by toxicities associated with conditioning regimens and to graft-versus-host disease (GVHD). Decades of animal studies have culminated into sufficien [...]

Open Access Review Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand? by Joachim Andrassy  and Antje Habicht Received: 05 November 2018;  Published: 27 June 2019;  doi: 10.21926/obm.transplant.1902070 Abstract In recent years, the potential of hematopoietic stem cells, regulatory T-cells, and mesenchymal stem cells have brought about a variety of clinical tolerance trials. Every approach has yielded promising results; however, the riddle of transplant tolerance has not been solved as of yet. The results of the ongoing trials in this field will provi [...]

Open Access Review Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation by Anouk A. J. Hamers  , Sunil K. Joshi  and Asha B. Pillai Received: 29 September 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901044 Abstract The success of tissue transplantation from a healthy donor to a diseased individual (allo-transplantation) is regulated by the immune systems of both donor and recipient. Developing a state of specific non‐reactivity between donor and recipient, while maintaining the salutary effects of immune function in the recipient, is called “ [...]

Open Access Review Cell based Therapy in Transplantation by Yi-nan Guo  , Michael Grzelak  and Byoung Chol Oh Received: 10 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.transplant.1804031 Abstract One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive therapies must be the development of a low-side [...]

Open Access Review Allogeneic Hematopoietic Cell Therapies to Induce Tolerance in Kidney Transplantation by Yujie Wen  , Anita Y. Chhabra  , Joseph R. Leventhal  and Suzanne T. Ildstad Received: 29 October 2018;  Published: 20 November 2018;  doi: 10.21926/obm.transplant.1804027 Abstract This review summarizes the latest results from the interventional clinical trials for inducing clinical tolerance in the recipients of human leukocyte antigen (HLA)-matched or mismatched living donor kidney transplants via allogeneic hematopoietic stem cell (HSC)-based therapies. The protocols utilized by the three medical centers in the Unite [...]

Open Access Review The Concerted Action of Multiple Mechanisms to Induce and Sustain Transplant Tolerance by Sylvaine You  and Lucienne Chatenoud Received: 25 September 2018;  Published: 09 November 2018;  doi: 10.21926/obm.transplant.1804025 Abstract Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in the induction and maintenance phases of [...]

Open Access Opinion The Holy Grail to Clinical Transplant Tolerance Is Paved with HLA Epitopes by Rene J. Duquesnoy Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018 Abstract The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes