OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.
The journal publishes all types of articles in English. There is no restriction on the length of the papers. We encourage authors to be concise but present their results in as much detail as necessary, as reviewers are expected to emphasize scientific rigor and reproducibility.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 6.7 weeks; Submission to Acceptance: 14.4 weeks; Acceptance to Publication: 6 days (1-2 days of FREE language polishing included)
Special Issue
Allogeneic Stem Cell Transplantation
Submission Deadline:
April 30, 2022 (Open)
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Guest Editor
Martin Guimond,
PhD
Associate Professor, Department of Microbiology, Infection, and Immunology, University of Montreal, Montreal, Quebec, Canada; Research Center, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
Website | E-Mail
Research Interests: T Lymphocytes; immunomodulation; allogeneic stem cell transplatation; stem cell transplantation; graft-versus-host disease; immunology
About this topic
In 1980, the New England Journal of Medicine published the first successful unrelated bone marrow transplantation to treat acute leukemia. Since then, the field of stem cell transplantation has evolved considerably. Today, allogeneic-SCT remains the only curative treatment for several patients with high risk refractory hematologic cancers. Recently, clinical trials were developed to evaluate the use of Allogeneic Stem Cell transplantation to treat/cure solid tumors. This Special Issue will cover new developments in the field of Allogeneic Stem Cell Transplantation including new procedures in Allogeneic Stem cell Transplantation, conditioning regiments, stem cell source, strategies to reduce/control acute or chronic graft-versus-host disease (T cell depletion, mesenchymal stem cells, suicide genes…), modulation of graft-versus leukemia (cytokines, CAR-T cells), management of infectious complications, strategies to improve immune reconstitution, in vitro and in vivo studies, animal models, and clinical trials on Allogeneic Stem Cell Transplantation. Original research papers, mini and full reviews and commentaries are all welcome. There is no restriction on the length of the manuscripts. Peer-review is commissioned immediately upon receipt of the manuscript.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (transplantation@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
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Publication
Open Access
Original Research
Abstract
Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. The immune cell receptor channel P2X7 and its [...]
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Abstract
Cytochrome P450 2J2 (CYP2J2) is one of the recently discovered enzymes that is involved in the metabolism of several drugs. It is mainly an extrahepatic enzyme which can, to some extent, explain some the drugs’ side effects such as cyclophosphamide (Cy). Cyclophosphamide is an alkylating agent that is commonly used in conditioning prior [...]
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Open Access
Research Article
Abstract
Allogeneic stem cell transplantation remains the only curative option for many hematological malignancies. Umbilical cord blood (UCB) is an alternate donor source with potentially increased morbidity in elderly patients. We evaluated outcomes in alternate donor sources, prior to the initiation of haploidentical transplantation at our instituti [...]
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Open Access
Original Research
Abstract
Acquired Severe Aplastic Anaemia (SAA) is a rare bone marrow failure syndrome, for which allogeneic haematopoietic stem cell transplant (HSCT) is a proven curative therapy. Despite excellent outcomes for matched sibling SAA recipients in terms of engraftment and survival, HSCT remains highly challenging in older matched-unrelated-donor (MUD [...]
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