Biomarkers in Transplantation
Submission Deadline: November 30, 2018 (Open) Submit Now
Mazhar A. Kanak, PhD
Assistant Professor, Transplant Surgery, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
E-Mail: [email protected]
Research Interests: Inflammation in islet transplantation; Nuclear Factor Kappa B (NFkB) regulation in inflammatory response; Mechanism of islet rejection; Diabetes Type 1 and 2 development; Biomarkers in transplantation; Tolerance induction; Novel immunosuppression for transplantation; Strategies to improve islet transplantation
About This Topic
Transplantation of organs, tissues, and cells as a cure for life threatening diseases is being performed for several decades now. The major challenge is to keep the graft healthy and alive for the lifetime of the patient. The use of immunosuppression has somewhat favored survival of graft but only temporarily. Detection and management of graft failure early enough to intervene the process of rejection has been widely sought. Biomarkers are molecular, biochemical, or morphological profiles or observations that can be used to monitor graft function, graft loss (acute/chronic), antibody mediated rejection, immune status of the patients etc. Several sources of biomarkers have been explored including protein signatures, mRNA expression, miRNA profiles, cell-free DNA and exosomal analysis. Technological advancement has enabled significant progress towards the development of novel biomarkers. Biomarkers in transplantation can be used to monitor immunosuppression profile, reduce morbidity, improve long-term graft survival and life-expectancy of the patient.
The scope of this special issue will be to introduce the role of biomarkers in transplantation, discuss the biomarkers currently in clinical practice in various forms of transplantation, and demonstrate the use of new technologies and research involved in the development of biomarkers. This special issue is open to all authors involved in the study and development of biomarkers in the area of clinical transplantation.
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