Severe Hypercholesterolemia Associated with Steroid-Refractory Acute Liver GVHD: Unusual Complication of Allogeneic Hematopoietic Cell Transplantation
OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Submission Deadline: September 15, 2020 (Open) Submit Now
Yvonne A. Efebera, MD
Associate Professor, Blood and Marrow Transplantation Program, Ohio State University, Columbus, Ohio, USA
Research Interests: Multiple myeloma; graft vs host disease; paraproteinemias; amyloidosis; necrobiotic xanthogranuloma; blood and marrow transplantation
About This Topic
Allogeneic hematopoietic stem cell transplant (alloHSCT) is a curative treatment for many hematologic malignancies. Unfortunately, about 30-50% of all recipients undergoing alloHSCT develop acute and chronic graft-versus-host-disease (aGVHD), which is associated with high morbidity and mortality [1, 2]. The pathophysiology of aGVHD is complex but involves the activation of host antigen presenting cells (APCs) by recipient conditioning which in turn activate transplanted donor T lymphocytes that expand and differentiate into effector cells that mediate cytotoxicity against recipient tissues through Fas-Fas ligand interactions, perforin-granzyme B, and cytokine production [2, 3, 4, 5]. When severe, aGVHD carries a poor prognosis, with only 25% long term survival for grade III and 5% for grade IV . Major contributing factors to severity of GVHD include HLA mismatch, conditioning regimen intensity, age of donor and recipient, source of stem cell (Peripheral blood, bone marrow, cord blood), and donor type (related, unrelated, haploidentical). Strategies and clinical trials are ongoing to reduce the incidence of GVHD, and to improve on the survival outcome of patients with GVHD, including the assessment of microRNAs and use of biomarkers guided management. This issue welcomes submission in any areas that focuses on GVHD mitigation and management.
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