OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Free Publication in 2019
Current Issue: 2019  Archive: 2018 2017

Special Issue

Human Islets for Diabetes Research and Transplantation

Submission Deadline: March 31, 2019 (Open)               Submit Now

Guest Editor

Tatsuya Kin, MD, PhD
Clinical Islet Laboratory, University of Alberta Hospital, 210 College Plaza, 8215-112 St, Edmonton, Alberta, Canada T6G2C8
E-Mail: [email protected]
Website: https://directory.ualberta.ca/person/tkin
Research Interests: Islet isolation; islet transplantation

About the Topic

The past decade has seen enormous progress in clinical islet transplantation as a therapy for type 1 diabetes, as well as steady expansion in human islet isolation activity worldwide. Islet isolation centers have been providing human islets for clinical transplantation and for basic research. Thanks to improvement of islet isolation technology and implementation of islet distribution programs, many basic researchers now have access to this valuable resource. In the face of recent recognition that human islets differ in a critical way from nonhuman counterparts, the demand of human islets for basic research is ever increasing and novel findings on human islet biology are accumulating. Also cells derived from human pancreatic tissue have a potential for future development of cellular based therapy for diabetes. The aim of this issue is to serve as a platform to update the current knowledge and recent progress in the basic research utilizing human islets as well as in clinical islet transplantation.

Planned Papers

Title: Islet transplantation to the other site than the portal vein.
Authors: Tomohiko Adachi, Susumu Eguchi
Affiliation: Nagasaki University, Japan

Title: Pancreatic islet isolation from marginal donors
Authors: Takayuki Anazawa, Hideaki Okajima, Shinji Uemoto

Title: Imaging Modalities to Quantify Pancreatic Islet Mass and Function
Author: M. Reza Mirbolooki
Affiliation: Southern California University of Health Sciences, USA

Title: Human islet isolation and distribution efforts for clinical and basic research
Authors: Natasha Hui Jin Ng 1, Wei Xuan Tan 1, Ye Xin Koh 2, Adrian Kee Keong Teo 1,3,4,5,*
Affiliations:
1 Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore
2 Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore
3 School of Biological Sciences, Nanyang Technological University, Singapore
4 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
5 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Title: The DPP4 inhibitor sitagliptin increases active GLP-1 levels from human islets and may increase islet cell survival prior to transplantation
Authors: Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E Light

Title: The G Protein-Coupled Estrogen Receptor GPER Plays a Dominant Role in Human Islet Cell Proliferation upon High Glucose
Authors: Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Gaby Shefer, Dalia Somjen, Naftali Stern

Publication

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Ibrahim Fathi, Takehiro Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi, Akiko Inagaki, Makiko Kikkawa, Fumiko Ono, Hiroo Iwata, Yohichi Yasunami, Masafumi Goto
Received: March 27, 2019; Published: July 09, 2019; doi:10.21926/obm.transplant.1903071

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active Glp-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062

Open Access Review

Islet Autotransplantations for Total Pancreatectomy

Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama  
Received: January 15, 2019; Published: April 03, 2019; doi:10.21926/obm.transplant.1902059

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