Current Issue: 2019  Archive: 2018   2017  

Special Issue

Human Islets for Diabetes Research and Transplantation

Submission Deadline: March 31, 2019 (Open)               Submit Now

Guest Editor

Tatsuya Kin, MD, PhD
Clinical Islet Laboratory, University of Alberta Hospital, 210 College Plaza, 8215-112 St, Edmonton, Alberta, Canada T6G2C8
E-Mail: [email protected]
Research Interests: Islet isolation; islet transplantation

About the Topic

The past decade has seen enormous progress in clinical islet transplantation as a therapy for type 1 diabetes, as well as steady expansion in human islet isolation activity worldwide. Islet isolation centers have been providing human islets for clinical transplantation and for basic research. Thanks to improvement of islet isolation technology and implementation of islet distribution programs, many basic researchers now have access to this valuable resource. In the face of recent recognition that human islets differ in a critical way from nonhuman counterparts, the demand of human islets for basic research is ever increasing and novel findings on human islet biology are accumulating. Also cells derived from human pancreatic tissue have a potential for future development of cellular based therapy for diabetes. The aim of this issue is to serve as a platform to update the current knowledge and recent progress in the basic research utilizing human islets as well as in clinical islet transplantation.

Planned Papers

Title: Islet transplantation to the other site than the portal vein.
Authors: Tomohiko Adachi, Susumu Eguchi
Affiliation: Nagasaki University, Japan

Title: Pancreatic islet isolation from marginal donors
Authors: Takayuki Anazawa, Hideaki Okajima, Shinji Uemoto

Title: Imaging Modalities to Quantify Pancreatic Islet Mass and Function
Author: M. Reza Mirbolooki
Affiliation: Southern California University of Health Sciences, USA

Title: Human islet isolation and distribution efforts for clinical and basic research
Authors: Natasha Hui Jin Ng 1, Wei Xuan Tan 1, Ye Xin Koh 2, Adrian Kee Keong Teo 1,3,4,5,*
1 Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore
2 Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore
3 School of Biological Sciences, Nanyang Technological University, Singapore
4 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
5 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

Title: The DPP4 inhibitor sitagliptin increases active GLP-1 levels from human islets and may increase islet cell survival prior to transplantation
Authors: Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E Light

Title: The G Protein-Coupled Estrogen Receptor GPER Plays a Dominant Role in Human Islet Cell Proliferation upon High Glucose
Authors: Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Gaby Shefer, Dalia Somjen, Naftali Stern



Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062


Islet Autotransplantations for Total Pancreatectomy

Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama  
Received: January 15, 2019; Published: April 03, 2019; doi:10.21926/obm.transplant.1902059