OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Isolation and Characterization of Adult Therapeutic Cells
Submission Deadline: June 30, 2019 (Open) Submit Now
Robert C. McCarthy
President, VitaCyte LLC, 1341 Sadlier Circle West Drive, Indianapolis, IN 46239, USA
E-Mail: [email protected]
Website: https://www.linkedin.com/in/robert-mccarthy-b31b7615; https://www.vitacyte.com/
Research Interests: Biotechnology; Cell Biology; Molecular Biology; Bioengineering
Stuart K. Williams II, Ph.D.
Professor, Cardiovascular Innovation Institute, Jewish Hospital and University of Louisville, Louisville, KY 40202, United States; Department of Physiology and Biophysics, Jewish Hospital and University of Louisville, Louisville, KY 40202, United States
Office: (502) 852-1379
E-Mail: [email protected]
Website: http://louisvillesurgery.com/drBios/williams_S.html; https://cv2i.org/investigators/stuart-k-williams-ph-d-inv/
Research Interests: (1) Cardiovascular Biomedical Engineering: Regenerative Medicine/Tissue Engineering, Stents and Stent Grafts, Adult Stem Cell Transplantation, Angiomics - Microarrays, Genomics and Proteomics, Shear Effects on Cells, Restenosis, Angiogenesis, Gene Therapy; (2) Biomaterials: Biomedical Implant Design, Direct –Write Printing – Biomimetics, Surface, Modification and Characterization, Soft Tissue Replacement, Cell Migration, Anti-Infective Coatings; (3) Diabetes Mellitus: Non Enzymatic Glycation, Capillary Permeability and Angiopathies, Islet Cell Transplantation
About This Topic
The increasing interest in using adult cells to develop cell therapeutics for management of patients with many different clinical conditions is at the forefront of medical treatment. These publications focus primarily on clinical outcomes with cursory attention paid to the preparation and characterization of the therapeutic cells used in the treatment. This issue focuses on key criteria to consider when isolating islets, hepatocytes, and mesenchymal stem cells from tissue for therapeutic use. The issue addressed for many of these cell types are the identification of critical process parameters in the cell isolation process; the impact of cell enrichment steps on functional activity; markers used to characterize the therapeutic cell population; and lastly status of potency assays required for releasing cells before transplant. If you are interested in submitting an article for inclusion in this special issue, please contact one of the guest editors.